Plasma Bmi1 mRNA as a potential prognostic biomarker for distant metastasis in colorectal cancer patients

Pun,Jason  Chun‑Sang; Chan,Joyce  Yee‑Jing; Chun,Bobby  Ka‑Ming; Ng,Ka‑Wai; Tsui,Samuel  Yung‑Kin; Wan,Timothy  Ming‑Hun; Lo,Oswens; Poon,Jensen  Tung‑Chung; Ng,Lui; Pang,Roberta

doi:10.3892/mco.2014.321

September-October 2014 Volume 2 Issue 5

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September-October 2014 Volume 2 Issue 5

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Article

Plasma Bmi1 mRNA as a potential prognostic biomarker for distant metastasis in colorectal cancer patients

Authors:
- Jason Chun‑Sang Pun
- Joyce Yee‑Jing Chan
- Bobby Ka‑Ming Chun
- Ka‑Wai Ng
- Samuel Yung‑Kin Tsui
- Timothy Ming‑Hun Wan
- Oswens Lo
- Jensen Tung‑Chung Poon
- Lui Ng
- Roberta Pang
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Affiliations: The Chinese Foundation Secondary School, Hong Kong, SAP, P.R. China, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, P.R. China
Pages: 817-820
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Published online on: June 20, 2014

https://doi.org/10.3892/mco.2014.321
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Abstract

Bmi1 is overexpressed in gastrointestinal cancers, including colorectal cancer (CRC); however, its role as a non‑invasive biomarker in CRC has not been established. The aim of this study was to compare the plasma Bmi1 mRNA levels prior to and following curative resection of the primary tumor in CRC patients and to determine their association with the clinicopathological parameters. The plasma Bmi1 mRNA level was measured by quantitative polymerase chain reaction and expressed as cycle threshold value. There was no significant difference between the overall pre‑ and postoperative plasma Bmi1 mRNA level (31.73±2.63 vs. 31.93±2.88, respectively; P=0.614) in 45 CRC patients. However, when grouped into non‑metastatic and metastatic CRC patients, the postoperative Bmi1 transcript level was found to be significantly lower compared to the preoperative level in patients with non‑metastatic CRC (32.13±2.677 31.44±2.764, respectively; P=0.041), whereas there was a trend towards a higher postoperative Bmi1 transcript level compared to the preoperative level in the metastatic counterpart (30.85±3.916 vs. 33.27±0.718, respectively; P=0.164). Furthermore, when the patients were categorized into two groups according to their plasma Bmi1 postoperative vs. preoperative level status, we observed that patients without a reduction in the postoperative plasma Bmi1 mRNA levels exhibited a significantly higher rate of distant metastasis following primary resection (P=0.017) and a significantly worse prognosis regarding disease‑free survival (P=0.016) when compared to the reduced postoperative plasma Bmi1 level counterparts. In conclusion, plasma Bmi1 mRNA levels may serve as a non‑invasive biomarker for monitoring occult metastasis and predicting the development of distant metastasis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Plasma Bmi1 mRNA as a potential prognostic biomarker for distant metastasis in colorectal cancer patients

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