search button

XAGE‑1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma

  • Authors:
    • Zeya Pan
    • Bikui Tang
    • Zhenyu Hou
    • Jin Zhang
    • Hui Liu
    • Yuan Yang
    • Gang Huang
    • Yun Yang
    • Weiping Zhou

  • View Affiliations

  • Published online on: July 4, 2014     https://doi.org/10.3892/mco.2014.336
  • Pages: 1155-1159
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

XAGE‑1b is a 470 bp transcript of the XAGE‑1 gene, which belongs to the cancer‑testis antigens that exhibit a restricted pattern of expression in normal tissues. Recently, the expression of XAGE‑1b has been shown to be frequent in patients with hepatocellular carcinoma (HCC). However, the underlying mechanism is not fully understood. To investigate the role of XAGE‑1b in HCC diagnosis and postoperative evaluation, the expression level of XAGE‑1b was first examined in the tissue and peripheral blood of HCC patients and controls by using quantitative polymerase chain reaction. Subsequently, the associations between XAGE‑1b and the clinical variables were assessed using χ2 or Kaplan‑Meier tests. The data showed that HCC tissues had increased XAGE‑1b expression when compared to paired non‑tumorous tissues. The blood samples from the HCC patients showed upregulated XAGE‑1b mRNA, as compared to non‑HCC patients. The patients with portal vein tumor thrombus or higher tumor‑node metastasis stages (II~IV) were more likely to have increased levels of XAGE‑1b mRNA. Furthermore, the 1‑year recurrence rate of the patients with a high level of XAGE‑1b mRNA was significantly greater compared to the patients with a low level. All these findings indicate that XAGE‑1b is associated with the aggressive biological behavior of HCC cells and it may be a potential biomarker for HCC diagnosis and prognosis.
View References

Related Articles

Journal Cover

November-December 2014
Volume 2 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 1.2
  • Ranked
    (total number of cites)
  • CiteScore: 2.6
  • CiteScore Rank: Q3: #242/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.693
  • SCImago Journal Rank (SJR): 0.393
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Pan Z, Tang B, Hou Z, Zhang J, Liu H, Yang Y, Huang G, Yang Y and Zhou W: XAGE‑1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma. Mol Clin Oncol 2: 1155-1159, 2014
APA
Pan, Z., Tang, B., Hou, Z., Zhang, J., Liu, H., Yang, Y. ... Zhou, W. (2014). XAGE‑1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma. Molecular and Clinical Oncology, 2, 1155-1159. https://doi.org/10.3892/mco.2014.336
MLA
Pan, Z., Tang, B., Hou, Z., Zhang, J., Liu, H., Yang, Y., Huang, G., Yang, Y., Zhou, W."XAGE‑1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma". Molecular and Clinical Oncology 2.6 (2014): 1155-1159.
Chicago
Pan, Z., Tang, B., Hou, Z., Zhang, J., Liu, H., Yang, Y., Huang, G., Yang, Y., Zhou, W."XAGE‑1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma". Molecular and Clinical Oncology 2, no. 6 (2014): 1155-1159. https://doi.org/10.3892/mco.2014.336