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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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November-December 2014 Volume 2 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

XAGE‑1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma

  • Authors:
    • Zeya Pan
    • Bikui Tang
    • Zhenyu Hou
    • Jin Zhang
    • Hui Liu
    • Yuan Yang
    • Gang Huang
    • Yun Yang
    • Weiping Zhou
  • View Affiliations / Copyright

    Affiliations: The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P.R. China, Department of Life Science, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China, Department of General Surgery, 153 Central Hospital of PLA, Zhengzhou, Henan 450007, P.R. China
  • Pages: 1155-1159
    |
    Published online on: July 4, 2014
       https://doi.org/10.3892/mco.2014.336
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Abstract

XAGE‑1b is a 470 bp transcript of the XAGE‑1 gene, which belongs to the cancer‑testis antigens that exhibit a restricted pattern of expression in normal tissues. Recently, the expression of XAGE‑1b has been shown to be frequent in patients with hepatocellular carcinoma (HCC). However, the underlying mechanism is not fully understood. To investigate the role of XAGE‑1b in HCC diagnosis and postoperative evaluation, the expression level of XAGE‑1b was first examined in the tissue and peripheral blood of HCC patients and controls by using quantitative polymerase chain reaction. Subsequently, the associations between XAGE‑1b and the clinical variables were assessed using χ2 or Kaplan‑Meier tests. The data showed that HCC tissues had increased XAGE‑1b expression when compared to paired non‑tumorous tissues. The blood samples from the HCC patients showed upregulated XAGE‑1b mRNA, as compared to non‑HCC patients. The patients with portal vein tumor thrombus or higher tumor‑node metastasis stages (II~IV) were more likely to have increased levels of XAGE‑1b mRNA. Furthermore, the 1‑year recurrence rate of the patients with a high level of XAGE‑1b mRNA was significantly greater compared to the patients with a low level. All these findings indicate that XAGE‑1b is associated with the aggressive biological behavior of HCC cells and it may be a potential biomarker for HCC diagnosis and prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Pan Z, Tang B, Hou Z, Zhang J, Liu H, Yang Y, Huang G, Yang Y and Zhou W: XAGE‑1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma. Mol Clin Oncol 2: 1155-1159, 2014.
APA
Pan, Z., Tang, B., Hou, Z., Zhang, J., Liu, H., Yang, Y. ... Zhou, W. (2014). XAGE‑1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma. Molecular and Clinical Oncology, 2, 1155-1159. https://doi.org/10.3892/mco.2014.336
MLA
Pan, Z., Tang, B., Hou, Z., Zhang, J., Liu, H., Yang, Y., Huang, G., Yang, Y., Zhou, W."XAGE‑1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma". Molecular and Clinical Oncology 2.6 (2014): 1155-1159.
Chicago
Pan, Z., Tang, B., Hou, Z., Zhang, J., Liu, H., Yang, Y., Huang, G., Yang, Y., Zhou, W."XAGE‑1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma". Molecular and Clinical Oncology 2, no. 6 (2014): 1155-1159. https://doi.org/10.3892/mco.2014.336
Copy and paste a formatted citation
x
Spandidos Publications style
Pan Z, Tang B, Hou Z, Zhang J, Liu H, Yang Y, Huang G, Yang Y and Zhou W: XAGE‑1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma. Mol Clin Oncol 2: 1155-1159, 2014.
APA
Pan, Z., Tang, B., Hou, Z., Zhang, J., Liu, H., Yang, Y. ... Zhou, W. (2014). XAGE‑1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma. Molecular and Clinical Oncology, 2, 1155-1159. https://doi.org/10.3892/mco.2014.336
MLA
Pan, Z., Tang, B., Hou, Z., Zhang, J., Liu, H., Yang, Y., Huang, G., Yang, Y., Zhou, W."XAGE‑1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma". Molecular and Clinical Oncology 2.6 (2014): 1155-1159.
Chicago
Pan, Z., Tang, B., Hou, Z., Zhang, J., Liu, H., Yang, Y., Huang, G., Yang, Y., Zhou, W."XAGE‑1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma". Molecular and Clinical Oncology 2, no. 6 (2014): 1155-1159. https://doi.org/10.3892/mco.2014.336
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