Association of a disintegrin and metalloprotease 33 gene polymorphisms with asthma

Yilihamu,Nigela; Wushouer,Qimangul; Arkin,Kadirya; Xin,Hu; Yadav,Umesh

doi:10.3892/mco.2014.339

November-December 2014 Volume 2 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

November-December 2014 Volume 2 Issue 6

Full Size Image

Article

Association of a disintegrin and metalloprotease 33 gene polymorphisms with asthma

Authors:
- Nigela Yilihamu
- Qimangul Wushouer
- Kadirya Arkin
- Hu Xin
- Umesh Yadav
View Affiliations / Copyright

Affiliations: Department of Respiratory Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China
Pages: 1076-1080
|
Published online on: July 9, 2014

https://doi.org/10.3892/mco.2014.339
Expand metrics +

Abstract

Various studies reported a disintegrin and metalloprotease 33 (ADAM33) as an important susceptibility gene for asthma, which is frequently detected among certain populations. The aim of the present study was to investigate the association between single‑nucleotide polymorphisms (SNPs) of the ADAM33 gene and asthma. Our case‑control study included 183 patients (73 male and 110 female, mean age 42.93±13.48 years) who were admitted in the First Affiliated Hospital of Xinjiang Medical University between February, 2012 and May, 2013 and 155 healthy controls (66 male and 89 female, mean age 41.14±14.10 years). Allele-specific polymerase chain reaction technology and DNA testing training methods were applied to detect the T2 and ST+5 polymorphisms of the ADAM33 gene. The data were statistically analyzed to determine whether there exists an association between these genotypes and asthma‑related morbidity. The genotypes and allele frequencies of the T2 and ST+5 SNPs of ADAM33 were not found to be significantly associated with asthma risk when compared between asthmatic patients and healthy controls (P>0.05). In addition, there was no association of the investigated SNPs with the severity of asthma. There was no significant difference in the forced vital capacity and the forced expiratory volume between patients with the ADAM33 T2 and ST+5 genotype. In conclusion, our results suggested that the T2 and ST+5 ADAM33 gene polymorphisms do not confer a significant risk of asthma or affect its severity in the population investigated.

View Figures

View References

1	Howard TD, Postma DS, Jongepier H, et al: Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. J Allergy Clin Immunol. 4:717–722. 2003. View Article : Google Scholar : PubMed/NCBI
2	Thongngarm T, Jameekornrak A, Limwongse C, et al: Association between ADAM33 polymorphisms and asthma in a Thai population. Asian Pac J Allergy Immunol. 26:205–211. 2008.PubMed/NCBI
3	Bijanzadeh M, Ramachandra NB, Mahesh PA, et al: Association of IL-4 and ADAM33 gene polymorphisms with asthma in an Indian population. Lung. 188:415–422. 2010. View Article : Google Scholar : PubMed/NCBI
4	Awasthi S, Tripathi P, Ganesh S and Husain N: Association of ADAM33 gene polymorphisms with asthma in Indian children. J Hum Genet. 56:188–195. 2011. View Article : Google Scholar : PubMed/NCBI
5	Wang P, Liu QJ, Li JS, et al: Lack of association between ADAM33 gene and asthma in a Chinese population. Int J Immunogenet. 33:303–306. 2006. View Article : Google Scholar : PubMed/NCBI
6	Sharma N, Tripathi P and Awasthi S: Role of ADAM33 gene and associated single nucleotide polymorphisms in asthma. Allergy Rhinol (Providence). 2:63–70. 2011. View Article : Google Scholar : PubMed/NCBI
7	Mayinu and Chen X: Evaluation of LOXL1 polymorphisms in exfoliation syndrome in the Uygur population. Mol Vis. 17:734–744. 2011.
8	Branch of Chinese Medical Association for Respiratory Diseases (BCMARD). Bronchial asthma therapeutic guidelines (definition, diagnosis, treatment of bronchial asthma). Chin J Tuberc Respir Dis. 31:177–185. 2008.(In Chinese).
9	Vercelli D: Genetics, epigenetic, and the environment: switching, buffering, releasing. J Allergy Clin Immunol. 113:381–386. 2004. View Article : Google Scholar : PubMed/NCBI
10	van Diemen CC, Postma DS, Vonk JM, Bruinenberg M, Schouten JP and Boezen HM: A disintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population. Am J Respir Crit Care Med. 172:329–333. 2005.PubMed/NCBI
11	Van Eerdewegh P, Little RD, Dupuis J, et al: Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature. 418:426–430. 2002.PubMed/NCBI
12	Postma DS and Howard T: ADAM33 gene: confirming a gene without linkage. Clin Exp Allergy. 34:1–3. 2004. View Article : Google Scholar : PubMed/NCBI
13	Simpson A, Maniatis N, Jury F, et al: Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function. Am J Respir Crit Care Med. 172:55–60. 2005. View Article : Google Scholar : PubMed/NCBI
14	Noguchi E, Ohtsuki Y, Tokunaga K, et al: ADAM33 polymorphisms are associated with asthma susceptibility in a Japanese population. Clin Exp Allergy. 36:602–608. 2006. View Article : Google Scholar : PubMed/NCBI
15	Sakagami T, Jinnai N, Nakajima T, et al: ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population. J Hum Genet. 52:66–72. 2007. View Article : Google Scholar : PubMed/NCBI
16	Su D, Zhang X, Sui H, et al: Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population. BMC Med Genet. 9:822008. View Article : Google Scholar : PubMed/NCBI
17	Lind DL, Choudhry S, Ung N, et al: ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med. 168:1312–1316. 2003. View Article : Google Scholar : PubMed/NCBI
18	Raby BA, Silverman EK, Kwiatkowski DJ, et al: ADAM33 polymorphisms and phenotype associations in childhood asthma. J Allergy Clin Immunol. 113:1071–1078. 2004. View Article : Google Scholar : PubMed/NCBI