Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
November-December 2014 Volume 2 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-December 2014 Volume 2 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Study of the effectiveness of first‑line treatment in renal cell carcinoma

  • Authors:
    • Alejandro J. Sastre‑Heres
    • Miguel Alaguero Calero
    • Daniel Ruiz‑Sánchez
    • María Teresa Iglesias García
    • Miguel Angel Calleja Hernandez
    • Fernando Martínez Martínez
    • Jaime Peña‑Díaz
  • View Affiliations / Copyright

    Affiliations: Hospital Pharmacy Department, Central University Hospital of Asturias, Oviedo, Asturias 33006, Spain, Hospital Pharmacy Department, Virgen de las Nieves Hospital, Granada 18014, Spain, Faculty of Pharmacy, University of Granada, Granada 18071, Spain
  • Pages: 1167-1171
    |
    Published online on: July 18, 2014
       https://doi.org/10.3892/mco.2014.353
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The emergence of novel drugs corresponds with the determination of the effectiveness of the current treatments used in clinical practice. A retrospective observational study was conducted to evaluate the effectiveness of first‑line treatments and to test the influence of the prognostic factors established using the Memorial Sloan‑Kettering Cancer Center (MSKCC) and the analysis of Mekhail's study for two or more metastatic sites. The primary endpoints were median progression‑free survival (mPFS) and median overall survival (mOS) times. A total of 65 patients were enrolled and the mPFS and mOS of the patients treated with sunitinib (n=51) were 9.0 and 20.1 months, respectively, and for the patients treated with temsirolimus (n=14) these were 3.0 and 6.2 months, respectively. In the poor‑prognosis (PP) group, a difference of 1.2 months (P=0.049) was found in mPFS depending on the first‑line treatment. A difference of 4.1 months (P=0.023) was also found in mPFS when classified by histology (clear verses non‑clear cell) in the sunitinib‑treatment group. When stratified by the prognostic group, differences of >7 months (P<0.001) were found between the groups. Therefore, it was concluded that the effectiveness of the treatments was reduced compared to previous studies and differences were found in the PP group when classified by first‑line drug and histology. Additionally, the influence of prognostic factors on OS and the value of stratifying patients using these factors have been confirmed.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Ljungberg B, Hanbury DC, Kuczyk MA, Merseburger AS, et al: Guía del carcinoma de células renales. Actas Urológicas Españolas. 33:270–279. 2004.(In Spanish).

2 

Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide. IARC CancerBase no. 11. International Agency for Research on Cancer; Lyon: 2013, http://globocan.iarc.fr. Accessed April 22, 2012

3 

Gobierno del Principado de Asturias. Mortalidad en Asturias. 2009, http://www.asturias.es/Astursalud/Ficheros/AS_Salud%20Publica/AS_Salud%20Poblacional/IS_Registro%20de%20mortalidad/mortalidad%20en%20Asturias%202009.pdf. (In Spanish). Accessed August 6, 2012

4 

Servicio de Salud del Principado de Asturias. Registro hospitalario de tumores del Servicio de Salud del Principado de Asturias. http://www.asturias.es/Astursalud/Ficheros/AS_SESPA/Memoria%20Rehotusespa%202009.pdf. (In Spanish). Accessed August 8, 2012

5 

Chow WH, Gridley G, Fraumeni JF Jr and Järvholm B: Obesity, hypertension, and the risk of kidney cancer in men. N Engl J Med. 343:1305–1311. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Cohen HT and McGovern FJ: Renal-cell carcinoma. N Engl J Med. 353:2477–2490. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Aguiló M, Alba F, Ballester M, et al: Carcinoma de las células renales. The Pharmaceutical letter. 9:pp. 85922007, (In Spanish) http://server.diaz-caneja-consultores.com/dicaf/site-v2/files/pharmaceuticalletter/The_Pharma_Letter_n10-2007.pdf. Accessed July 10, 2014

8 

Motzer RJ, Bacik J, Murphy BA, Russo P and Mazumdar M: Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol. 20:289–296. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Escudier B and Kataja V; ESMO Guidelines Working Group. Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 21(Suppl 5): v137–v139. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Mekhail TM, Abou-Jawde RM, Boumerhi G, et al: Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma. J Clin Oncol. 23:832–841. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Hudes G, Carducci M, Tomczak P, et al; Global ARCC Trial. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med. 356:2271–2281. 2007. View Article : Google Scholar

12 

Heng DY, Xie W, Regan MM, et al: Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study. J Clin Oncol. 27:5794–5799. 2009. View Article : Google Scholar

13 

Patil S, Figlin RA, Hutson TE, et al: Prognostic factors for progression-free and overall survival with sunitinib targeted therapy and with cytokine as first-line therapy in patients with metastatic renal cell carcinoma. Ann Oncol. 22:295–300. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Motzer RJ, Hutson TE, Tomczak P, et al: Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 356:115–124. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Gore ME, Szczylik C, Porta C, et al: Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial. Lancet Oncol. 10:757–763. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Sun M, Lughezzani G, Perrotte P and Karakiewicz PI: Treatment of metastatic renal cell carcinoma. Nat Rev Urol. 7:327–338. 2010. View Article : Google Scholar

17 

Hutson TE: Targeted therapies for the treatment of metastatic renal cell carcinoma: clinical evidence. Oncologist. 16(Suppl 2): 14–22. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Motzer RJ, Hutson TE, Tomczak P, et al: Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol. 27:3584–3590. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Kidney Cancer. NCCN Clinical Practice Guidelines in Oncology. Version 3.2014 http://www.nccn.org/professionals/physician_gls/pdf/kidney.pdf. Accessed March 22, 2014

20 

Lee WK, Byun SS, Kim HH, Rha KH, Hwang TK, Sung GT, et al: Characteristics and prognosis of chromophobe non-metastatic renal cell carcinoma: a multicenter study. Int J Urol. 17:898–904. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Molina AM, Feldman DR, Ginsberg MS, et al: Phase II trial of sunitinib in patients with metastatic non-clear cell renal cell carcinoma. Invest New Drugs. 30:335–340. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Motzer RJ, Mazumdar M, Bacik J, Berg W, Amsterdam A and Ferrara J: Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol. 17:2530–2540. 1999.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sastre‑Heres AJ, Alaguero Calero M, Ruiz‑Sánchez D, Iglesias García MT, Calleja Hernandez MA, Martínez Martínez F and Peña‑Díaz J: Study of the effectiveness of first‑line treatment in renal cell carcinoma. Mol Clin Oncol 2: 1167-1171, 2014.
APA
Sastre‑Heres, A.J., Alaguero Calero, M., Ruiz‑Sánchez, D., Iglesias García, M.T., Calleja Hernandez, M.A., Martínez Martínez, F., & Peña‑Díaz, J. (2014). Study of the effectiveness of first‑line treatment in renal cell carcinoma. Molecular and Clinical Oncology, 2, 1167-1171. https://doi.org/10.3892/mco.2014.353
MLA
Sastre‑Heres, A. J., Alaguero Calero, M., Ruiz‑Sánchez, D., Iglesias García, M. T., Calleja Hernandez, M. A., Martínez Martínez, F., Peña‑Díaz, J."Study of the effectiveness of first‑line treatment in renal cell carcinoma". Molecular and Clinical Oncology 2.6 (2014): 1167-1171.
Chicago
Sastre‑Heres, A. J., Alaguero Calero, M., Ruiz‑Sánchez, D., Iglesias García, M. T., Calleja Hernandez, M. A., Martínez Martínez, F., Peña‑Díaz, J."Study of the effectiveness of first‑line treatment in renal cell carcinoma". Molecular and Clinical Oncology 2, no. 6 (2014): 1167-1171. https://doi.org/10.3892/mco.2014.353
Copy and paste a formatted citation
x
Spandidos Publications style
Sastre‑Heres AJ, Alaguero Calero M, Ruiz‑Sánchez D, Iglesias García MT, Calleja Hernandez MA, Martínez Martínez F and Peña‑Díaz J: Study of the effectiveness of first‑line treatment in renal cell carcinoma. Mol Clin Oncol 2: 1167-1171, 2014.
APA
Sastre‑Heres, A.J., Alaguero Calero, M., Ruiz‑Sánchez, D., Iglesias García, M.T., Calleja Hernandez, M.A., Martínez Martínez, F., & Peña‑Díaz, J. (2014). Study of the effectiveness of first‑line treatment in renal cell carcinoma. Molecular and Clinical Oncology, 2, 1167-1171. https://doi.org/10.3892/mco.2014.353
MLA
Sastre‑Heres, A. J., Alaguero Calero, M., Ruiz‑Sánchez, D., Iglesias García, M. T., Calleja Hernandez, M. A., Martínez Martínez, F., Peña‑Díaz, J."Study of the effectiveness of first‑line treatment in renal cell carcinoma". Molecular and Clinical Oncology 2.6 (2014): 1167-1171.
Chicago
Sastre‑Heres, A. J., Alaguero Calero, M., Ruiz‑Sánchez, D., Iglesias García, M. T., Calleja Hernandez, M. A., Martínez Martínez, F., Peña‑Díaz, J."Study of the effectiveness of first‑line treatment in renal cell carcinoma". Molecular and Clinical Oncology 2, no. 6 (2014): 1167-1171. https://doi.org/10.3892/mco.2014.353
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team