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Molecular and Clinical Oncology
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Article

Pre‑chemotherapy preservation of fertility in male patients with high‑grade malignant bone and soft tissue tumors

  • Authors:
    • Manabu Hoshi
    • Naoto Oebisu
    • Jun Takada
    • Tadashi Iwai
    • Rie Tsuruta
    • Hiroaki Nakamura
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka 545‑8585, Japan, Department of Nursing Office, Osaka City University Graduate School of Medicine, Osaka 545‑8585, Japan
  • Pages: 1111-1114
    |
    Published online on: August 1, 2014
       https://doi.org/10.3892/mco.2014.367
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Abstract

Only a limited number of orthopedic oncologists make arrangements for pre‑chemotherapy fertility preservation, such as sperm cryopreservation, for their patients. The purpose of this study was to offer fertility preservation to male patients with high‑grade malignant bone and soft tissue tumors and assess the outcomes. The study included 14 male patients, aged <45 years, with high‑grade bone and soft tissue tumors. The median age at diagnosis was 23.0±12.0 years (range, 8‑42 years). Following pathological confirmation of high‑grade malignant tumor, we informed all the patients and/or their guardians on the issue of chemotherapy‑related male infertility. If the patients were interested in preserving fertility, they were referred to a team of reproductive specialists. We documented the patients' clinical characteristics and techniques used for fertility preservation. The majority of unmarried and childless patients were interested in fertility preservation. Four patients (28.5%) selected sperm cryopreservation and 1 patient (7.1%) selected hemi‑testicular preservation, as he had developed erectile dysfunction following previous surgery for colon cancer. Married patients and those with children did not wish to preserve fertility. In conclusion, infertility following chemotherapy raises serious concerns for young male patients with high‑grade bone and soft tissue tumors. Prior to initiating chemotherapy, the potential risks of chemotherapy should be explained, counseling should be provided and informed consent should be obtained from the patients, ideally without delaying commencement of cancer treatment. Prior to administering cancer chemotherapy, orthopedic oncologists are encouraged to offer sperm banking to young male patients at risk of infertility.
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Copy and paste a formatted citation
Spandidos Publications style
Hoshi M, Oebisu N, Takada J, Iwai T, Tsuruta R and Nakamura H: Pre‑chemotherapy preservation of fertility in male patients with high‑grade malignant bone and soft tissue tumors. Mol Clin Oncol 2: 1111-1114, 2014.
APA
Hoshi, M., Oebisu, N., Takada, J., Iwai, T., Tsuruta, R., & Nakamura, H. (2014). Pre‑chemotherapy preservation of fertility in male patients with high‑grade malignant bone and soft tissue tumors. Molecular and Clinical Oncology, 2, 1111-1114. https://doi.org/10.3892/mco.2014.367
MLA
Hoshi, M., Oebisu, N., Takada, J., Iwai, T., Tsuruta, R., Nakamura, H."Pre‑chemotherapy preservation of fertility in male patients with high‑grade malignant bone and soft tissue tumors". Molecular and Clinical Oncology 2.6 (2014): 1111-1114.
Chicago
Hoshi, M., Oebisu, N., Takada, J., Iwai, T., Tsuruta, R., Nakamura, H."Pre‑chemotherapy preservation of fertility in male patients with high‑grade malignant bone and soft tissue tumors". Molecular and Clinical Oncology 2, no. 6 (2014): 1111-1114. https://doi.org/10.3892/mco.2014.367
Copy and paste a formatted citation
x
Spandidos Publications style
Hoshi M, Oebisu N, Takada J, Iwai T, Tsuruta R and Nakamura H: Pre‑chemotherapy preservation of fertility in male patients with high‑grade malignant bone and soft tissue tumors. Mol Clin Oncol 2: 1111-1114, 2014.
APA
Hoshi, M., Oebisu, N., Takada, J., Iwai, T., Tsuruta, R., & Nakamura, H. (2014). Pre‑chemotherapy preservation of fertility in male patients with high‑grade malignant bone and soft tissue tumors. Molecular and Clinical Oncology, 2, 1111-1114. https://doi.org/10.3892/mco.2014.367
MLA
Hoshi, M., Oebisu, N., Takada, J., Iwai, T., Tsuruta, R., Nakamura, H."Pre‑chemotherapy preservation of fertility in male patients with high‑grade malignant bone and soft tissue tumors". Molecular and Clinical Oncology 2.6 (2014): 1111-1114.
Chicago
Hoshi, M., Oebisu, N., Takada, J., Iwai, T., Tsuruta, R., Nakamura, H."Pre‑chemotherapy preservation of fertility in male patients with high‑grade malignant bone and soft tissue tumors". Molecular and Clinical Oncology 2, no. 6 (2014): 1111-1114. https://doi.org/10.3892/mco.2014.367
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