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Molecular and Clinical Oncology
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Article

Efficacy of gemcitabine combined with oxaliplatin, L‑asparaginase and dexamethasone in patients with newly‑diagnosed extranodal NK/T‑cell lymphoma

  • Authors:
    • Hong‑Qiang Guo
    • Lei Liu
    • Xin‑Feng Wang
    • Tong‑Yu Lin
    • Shu‑Na Yao
    • Zhi‑Hua Yao
    • Shu‑Jun Yang
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan 450008, P.R. China, Department of Medical Oncology, Cancer Center, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China
  • Pages: 1172-1176
    |
    Published online on: August 1, 2014
       https://doi.org/10.3892/mco.2014.368
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Abstract

There is currently no standard first‑line regimen for patients with extranodal natural killer (NK)/T‑cell lymphoma (ENKTCL). In this study, we investigated the efficacy and toxicity of gemcitabine (GEM) combined with oxaliplatin (L‑OHP), L‑asparaginase (L‑ASP) and dexamethasone (DXM) (GOLD regimen) as a systemic treatment scheme for newly‑diagnosed ENKTCL cases. A total of 55 patients were recruited at the Henan province cancer hospital and the Cancer Center of Sun Yat‑sen University between May, 2008 and August, 2012. The GOLD regimen included a 14‑day treatment cycle with GEM (1,000 mg/m2) on day 1, L‑OHP (100 mg/m2) on day 1, L‑ASP (10,000 U/m2) on days 1‑5 and DXM (20 mg b.i.d.) on days 1‑4. The response rate, survival rate and treatment toxicity were analyzed. The overall response rate was 91% (48/55) with a complete response in 62% (34/55) and a partial response in 29% (15/55) of the patients. For all patients, the 1‑, 2‑ and 3‑year progression‑free survival (PFS) rate was 86, 64 and 57% and the overall survival (OS) 91, 80 and 74%, respectively. The 1‑year PFS in patients with stage I̸II vs. those with III/IV disease was 87 vs. 66% (p<0.001) and the 1‑year OS was 98 vs. 75%, respectively (p<0.001). No chemotherapy‑related mortality or severe complications were recorded. In conclusion, the GOLD regimen was found to be highly effective and safe for the treatment of patients with newly‑diagnosed ENKTCL.
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1 

Suzuki R, Takeuchi K, Ohshima K and Nakamura S: Extranodal NK/T-cell lymphoma: diagnosis and treatment cues. Hematol Oncol. 26:66–72. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Oshimi K: Progress in understanding and managing natural killer-cell malignancies. Br J Haematol. 139:532–544. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Liang Q, Ye ZY, Su ZL, et al: Clinicopathologic study of 963 cases of mature T-cell and natural killer/T-cell lymphoma with respect to 2008 WHO classification of lymphoid neoplasms. Chin J Pathol. 39:291–295. 2010.(In Chinese).

4 

Li YX, Wang H, Jin J, et al: Radiotherapy alone with curative intent in patients with stage I extranodal nasal-type NK/T-cell lymphoma. Int J Radiat Oncol Biol Phys. 82:1809–1815. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Li YX, Yao B, Jin J, Wang WH, et al: Radiotherapy as primary treatment for stage IE and IIE nasal natural killer/T-cell lymphoma. J Clin Oncol. 24:181–189. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Isobe K, Uno T, Tamaru J, et al: Extranodal natural killer/T-cell lymphoma, nasal type: the significance of radiotherapeutic parameters. Cancer. 106:609–615. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Koom WS, Chung EJ, Yang WI, et al: Angiocentric T-cell and NK/T-cell lymphomas: radiotherapeutic viewpoints. Int J Radiat Oncol Biol Phys. 59:1127–1137. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Wang B, Li XQ, Ma X, Hong X, Lu H and Guo Y: Immunohistochemical expression and clinical significance of P-glycoprotein in previously untreated extranodal NK/T-cell lymphoma, nasal type. Am J Hematol. 83:795–799. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Drénou B, Lamy T, Amiot L, et al: CD3− CD56+ non-Hodgkin’s lymphomas with an aggressive behavior related to multidrug resistance. Blood. 89:2966–2974. 1997.

10 

Jaccard A, Petit B, Girault S, et al: L-asparaginase-based treatment of 15 western patients with extranodal NK/T-cell lymphoma and leukemia and a review of the literature. Ann Oncol. 20:110–116. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Obama K, Tara M and Niina K: L-asparaginase-based induction therapy for advanced extranodal NK/T-cell lymphoma. Int J Hematol. 78:248–250. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Nagafuji K, Fujisaki T, Arima F and Ohshima K: L-asparaginase induced durable remission of relapsed nasal NK/T-cell lymphoma after autologous peripheral blood stem cell transplantation. Int J Hematol. 74:447–450. 2001. View Article : Google Scholar

13 

Yong W, Zheng W, Zhu J, et al: L-asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type. Ann Hematol. 88:647–652. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Ahn HK, Kim SJ, Hwang DW, Ko YH, Tang T, Lim ST and Kim WS: Gemcitabine alone and/or containing chemotherapy is efficient in refractory or relapsed NK/T-cell lymphoma. Invest New Drugs. 31:469–472. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Mounier N, El Gnaoui T, Tilly H, et al: Rituximab plus gemcitabine and oxaliplatin in patients with refractory/relapsed diffuse large B-cell lymphoma who are not candidates for high-dose therapy. A phase II Lymphoma Study Association trial. Haematologica. 98:1726–1731. 2013. View Article : Google Scholar : PubMed/NCBI

16 

López A, Gutiérrez A, Palacios A, et al: GEMOX-R regimen is a highly effective salvage regimen in patients with refractory/relapsing diffuse large-cell lymphoma: a phase II study. Eur J Haematol. 80:127–132. 2008.PubMed/NCBI

17 

El Gnaoui T, Dupuis J, Belhadj K, et al: Rituximab, gemcitabine and oxaliplatin: an effective salvage regimen for patients with relapsed or refractory B-cell lymphoma not candidates for high-dose therapy. Ann Oncol. 18:1363–1368. 2007.PubMed/NCBI

18 

Nowak-Göttl U, Ahlke E, Fleischhack G, et al: Thromboembolic events in children with acute lymphoblastic leukemia (BFM protocols): prednisone versus dexamethasone administration. Blood. 101:2529–2533. 2003.

19 

Carbone PP, Kaplan HS, Musshoff K, Smithers DW and Tubiana M: Report of the Committee on Hodgkin’s Disease Staging Classification. Cancer Res. 31:1860–1861. 1971.

20 

Cheson BD, Horning SJ, Coiffier B, et al: Report of an international workshop to standardize response criteria for non-Hodgkin’s lymphomas. NCI Sponsored International Working Group. J Clin Oncol. 17:12441999.PubMed/NCBI

21 

Trotti A, Colevas AD, Setser A, et al: CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol. 13:176–181. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Au WY, Weisenburger DD, Intragumtornchai T, et al; International Peripheral T-Cell Lymphoma Project. Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project. Blood. 113:3931–3937. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Yong W, Zheng W and Zhang Y: Clinical characteristics and treatment of midline nasal and nasal type NK/T cell lymphoma. Zhonghua Yi Xue Za Zhi. 81:773–775. 2001.(In Chinese).

24 

Lin N, Song Y, Zheng W, et al: A prospective phase II study of L-asparaginase- CHOP plus radiation in newly diagnosed extranodal NK/T-cell lymphoma, nasal type. J Hematol Oncol. 6:442013. View Article : Google Scholar : PubMed/NCBI

25 

Au WY, Lie AK, Liang R, et al: Autologous stem cell transplantation for nasal NK/T-cell lymphoma: a progress report on its value. Ann Oncol. 14:1673–1676. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Kim HJ, Bang SM, Lee J, et al: High-dose chemotherapy with autologous stem cell transplantation in extranodal NK/T-cell lymphoma: a retrospective comparison with non-transplantation cases. Bone Marrow Transplant. 37:819–824. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Yamaguchi M, Kwong YL, Kim WS, et al: Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study. J Clin Oncol. 29:4410–4416. 2011. View Article : Google Scholar

28 

Wu X, Li P, Zhao J, et al: A clinical study of 115 patients with extranodal natural killer/T-cell lymphoma, nasal type. Clin Oncol (R Coll Radiol). 20:619–625. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Li YX, Fang H, Liu QF, et al: Clinical features and treatment outcome of nasal-type NK/T-cell lymphoma of Waldeyer ring. Blood. 112:3057–3064. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guo HQ, Liu L, Wang XF, Lin TY, Yao SN, Yao ZH and Yang SJ: Efficacy of gemcitabine combined with oxaliplatin, L‑asparaginase and dexamethasone in patients with newly‑diagnosed extranodal NK/T‑cell lymphoma. Mol Clin Oncol 2: 1172-1176, 2014.
APA
Guo, H., Liu, L., Wang, X., Lin, T., Yao, S., Yao, Z., & Yang, S. (2014). Efficacy of gemcitabine combined with oxaliplatin, L‑asparaginase and dexamethasone in patients with newly‑diagnosed extranodal NK/T‑cell lymphoma. Molecular and Clinical Oncology, 2, 1172-1176. https://doi.org/10.3892/mco.2014.368
MLA
Guo, H., Liu, L., Wang, X., Lin, T., Yao, S., Yao, Z., Yang, S."Efficacy of gemcitabine combined with oxaliplatin, L‑asparaginase and dexamethasone in patients with newly‑diagnosed extranodal NK/T‑cell lymphoma". Molecular and Clinical Oncology 2.6 (2014): 1172-1176.
Chicago
Guo, H., Liu, L., Wang, X., Lin, T., Yao, S., Yao, Z., Yang, S."Efficacy of gemcitabine combined with oxaliplatin, L‑asparaginase and dexamethasone in patients with newly‑diagnosed extranodal NK/T‑cell lymphoma". Molecular and Clinical Oncology 2, no. 6 (2014): 1172-1176. https://doi.org/10.3892/mco.2014.368
Copy and paste a formatted citation
x
Spandidos Publications style
Guo HQ, Liu L, Wang XF, Lin TY, Yao SN, Yao ZH and Yang SJ: Efficacy of gemcitabine combined with oxaliplatin, L‑asparaginase and dexamethasone in patients with newly‑diagnosed extranodal NK/T‑cell lymphoma. Mol Clin Oncol 2: 1172-1176, 2014.
APA
Guo, H., Liu, L., Wang, X., Lin, T., Yao, S., Yao, Z., & Yang, S. (2014). Efficacy of gemcitabine combined with oxaliplatin, L‑asparaginase and dexamethasone in patients with newly‑diagnosed extranodal NK/T‑cell lymphoma. Molecular and Clinical Oncology, 2, 1172-1176. https://doi.org/10.3892/mco.2014.368
MLA
Guo, H., Liu, L., Wang, X., Lin, T., Yao, S., Yao, Z., Yang, S."Efficacy of gemcitabine combined with oxaliplatin, L‑asparaginase and dexamethasone in patients with newly‑diagnosed extranodal NK/T‑cell lymphoma". Molecular and Clinical Oncology 2.6 (2014): 1172-1176.
Chicago
Guo, H., Liu, L., Wang, X., Lin, T., Yao, S., Yao, Z., Yang, S."Efficacy of gemcitabine combined with oxaliplatin, L‑asparaginase and dexamethasone in patients with newly‑diagnosed extranodal NK/T‑cell lymphoma". Molecular and Clinical Oncology 2, no. 6 (2014): 1172-1176. https://doi.org/10.3892/mco.2014.368
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