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Article

Apolipoprotein E genetic polymorphism, serum lipoprotein levels and breast cancer risk: A case-control study

  • Authors:
    • Gabriela Herrmann Cibeira
    • Juliana Giacomazzi
    • Ernestina Aguiar
    • Silvana Schneider
    • Betina Ettrich
    • Caroline Isoppo De Souza
    • Suzi Camey
    • Maira Caleffi
    • Bernardete Weber
    • Patricia Ashton-Prolla
    • Emilio Hideyuki Moriguchi
  • View Affiliations / Copyright

    Affiliations: Post-Graduate Program in Health Sciences, Cardiology and Cardiovascular Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil, Post-Graduate Program in Genetics and Molecular Biology, HCPA/UFRGS, Porto Alegre, Brazil, Laboratory of Genomic Medicine, Experimental Research Center/Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil, Post‑Graduate Program in Medicine: Medical Sciences, UFRGS/HCPA, Porto Alegre, Brazil, Post-Graduate Program in Epidemiology, Department of Statistics, Institute of Mathematics, UFRGS, Porto Alegre, Brazil, Coorte Núcleo Mama Porto Alegre, Hospital Moinhos de Vento, Porto Alegre, Brazil, Hospital do Coração, São Paulo, Brazil
  • Pages: 1009-1015
    |
    Published online on: August 1, 2014
       https://doi.org/10.3892/mco.2014.369
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Abstract

The purpose of this study was to evaluate the association between apolipoprotein E (APOE) allelic frequency, serum lipoproteins and breast cancer (BC). We conducted a nested case-control study within a cohort including 47 cases and 165 controls. Polymerase chain reaction-restriction fragment length polymorphism analyses of the APOE polymorphism were performed. In general, participants with the genotype including alleles e2 and e3 tended to have lower serum triglycerides, total cholesterol and low‑density lipoprotein cholesterol levels and higher high‑density lipoprotein (HDL) cholesterol levels compared to participants homozygous for the e3 allele and participants heterozygous for the e3 and e4 alleles, respectively. BC patients exhibited higher mean levels of total serum cholesterol (p=0.070), dietary fat intake (p=0.020) and dietary cholesterol intake (p=0.017) compared to control subjects. The allelic distribution between the two groups revealed that the presence of the e2 allele was positively associated with the absence of BC, whereas the e4 allele was positively associated with the BC case group (p=0.019). The distribution of the APOE genotypes was not significantly different between cases and controls (p=0.172). The concomitant presence of the e2 and e4 alleles was positively associated with the absence of BC and e4/e4 homozygosity was positively associated with BC (p=0.021). Our findings suggested that APOE polymorphism plays an important role in the development of BC, particularly when associated with higher serum triglyceride levels.
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1 

Beisiegel U, Weber W, Ihrke G, et al: The LDL-receptor related protein, LPR, is an apolipoprotein E-binding protein. Nature. 341:162–170. 1989. View Article : Google Scholar : PubMed/NCBI

2 

Eichner JE, Dunn T, Perveen G, Thompson DM, Stewart KE and Stroehla BC: Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review. Am J Epidemiol. 155:487–495. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Mahley RW and Rall SC Jr: Apolipoprotein E: Far more than a lipid transport protein. Annu Rev Genomics Hum Gene. 1:507–537. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Hartman RE, Laurer H, Longhi L, Bales KR, Paul SM, McIntosh TK and Holtzman DM: Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer’s disease. J Neurosci. 22:10083–10087. 2002.

5 

Moysich KB, Freudenheim JL, Baker JA, et al: Apolipoprotein E genetic polymorphism, serum lipoproteins, and breast cancer risk. Mol Carcinog. 27:2–9. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Zunarelli E, Nicoll JA, Migaldi M and Trentini GP: Apolipoprotein E polymorphism and breast carcinoma: correlation with cell proliferation indices and clinical outcome. Breast Cancer Res Treat. 63:193–198. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Breslow JL: Genetic basis of lipoprotein disorders. J Clin Invest. 84:373–380. 1989. View Article : Google Scholar : PubMed/NCBI

8 

Kervinen K, Södervik H, Mäkelä J, Lehtola J, Niemi M, Kairaluoma MI and Kesäniemi YA: Is the development of adenoma and carcinoma in proximal colon related to apolipoprotein E genotype? Gastroenerology. 110:1785–1790. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Kuusisto J, Koivisto K, Kervinen K, et al: Association of apolipoprotein phenotypes with late onset Alzheimer’s disease: population based study. BMJ. 309:636–638. 1994.

10 

Cave WT Jr: Dietary fat effects on animal models of breast cancer. Diet and Breast Cancer. Weisburger EK: Plenum Press; New York: pp. 47–58. 1994, View Article : Google Scholar

11 

Caroll KK, Braden LM, Bell JM and Kalamegham R: Fat and cancer. Cancer. 58:1818–1825. 1986. View Article : Google Scholar

12 

Dunn JE: Breast cancer among American Japanese in the San Francisco bay area. Natl Canc Inst Monogr. 47:157–160. 1977.PubMed/NCBI

13 

Willett WC, Hunter DJ, Stampfer MJ, et al: Dietary fat and fiber in relation to risk of breast cancer. An 8-year follow up. JAMA. 268:2037–2044. 1992.PubMed/NCBI

14 

Goodwin PJ and Boyd NF: Critical appraisal of the evidence that dietary fat intake is related to breast cancer in humans. J Natl Cancer Inst. 79:473–485. 1987.PubMed/NCBI

15 

Bingham SA, Gill C, Welch A, et al: Comparison of dietary assessment methods in nutritional epidemiology: weighted records v. 24 h recalls, food-frequency questionnaries and estimated-diet records. Br J Nut. 72:619–643. 1994. View Article : Google Scholar

16 

Törnberg SA, Holm LE and Carstensen JM: Breast cancer risk in relation to serum cholesterol, serum beta-lipoprotein, height, weight, and blood pressure. Acta Oncol. 27:31–37. 1988.PubMed/NCBI

17 

Vatten LJ and Foss OP: Total serum cholesterol and triglycerides and risk of breast cancer: a prospective study of 24,329 Norwegian women. Cancer Res. 50:2341–2346. 1990.PubMed/NCBI

18 

Gerber M, Cavallo F, Marubini E, et al: Liposoluble vitamins and lipid parameters in breast cancer. A joint study in northern Italy and southern France. Int J Cancer. 42:489–494. 1988. View Article : Google Scholar : PubMed/NCBI

19 

Vatten LJ, Foss OP and Kvinnsland S: Overall survival of breast cancer patients in relation to preclinically determined total serum cholesterol, body mass index, height and cigarette smoking: a population-based study. Eur J Cancer. 27:641–646. 1991. View Article : Google Scholar

20 

Høyer AP and Engholm G: Serum lipids and breast cancer risk: a cohort study of 5,207 Danish women. Cancer Causes Control. 3:403–480. 1992.PubMed/NCBI

21 

Kökoğlu E, Karaarslan I, Karaarslan HM and Baloglu H: Alterations of serum lipids and lipoproteins in breast cancer. Cancer Lett. 82:175–178. 1994.PubMed/NCBI

22 

Giacomazzi J, Aguiar E, Palmero EI, et al: Breast cancer screening in 10.000 women of an underserved population in South Brazil: The NMAMAPOA cohort. J Clin Oncol. 23:1020–1027. 2005.

23 

Caleffi M, Ribeiro RA, Duarte Filho DL, et al: A model to optimize public health care and downstage breast cancer in limited-resource populations in southern Brazil. Porto Alegre Breast Health Intervention Cohort. BMC Public Health. 9:832009.PubMed/NCBI

24 

Chang SJ, Hou MF, Tsai SM, Kao JT, Wu SH, Hou LA and Tsai LY: Association between the apolipoprotein E genotypes and breast cancer patients in Taiwanese. Breast Cancer Res Treat. 98:109–113. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Sposito AC, Caramelli B, Fonseca FA, et al; Brazilian Society of Cardiology. IV Brazilian guideline for dyslipidemia and atherosclerosis prevention: Department of Atherosclerosis of Brazilian Society of Cardiology. Arq Bras Cardiol. 88:2–19. 2007.(In Portuguese).

26 

Hixson JE and Vernier DT: Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hha I. J Lipid Res. 31:545–548. 1990.PubMed/NCBI

27 

Howard BV, Gidding SS and Liu K: Association of apolipoprotein E phenotype with plasma lipoproteins in African-American and white young adults. The CARDIA Study Coronary Artery Risk Development in Young Adults. Am J Epidemiol. 48:859–868. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Niemi M, Kervinen K, Kiviniemi H, et al: Apolipoprotein E phenotype, cholesterol and breast and prostate cancer. J Epidemiol Community Health. 54:938–939. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Ojopi EPB, Bertoncini AB and Dias Neto E: Apolipoproteína E e a doença de Alzheimer. Rev Psiq Clí. 31:26–33. 2004.

30 

Chang NW, Chen DR, Wu CT, Aouizerat BE, Chen FN, Hung SJ, Wang SH, Wei MF and Chang CS: Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan. Breast Cancer Res Treat. 90:257–261. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Brandão AC, Pinheiro SP Jr, Pinhel MA, et al: Polimorfismo genético da apolipoproteína E na doença arterial periférica. J Vasc Br. 3:317–322. 2004.PubMed/NCBI

32 

Feng J, Xiang L, Wan G, et al: Is APOE E a favorable factor for the longevity: an association study in Chinese population. J Genet. 90:343–347. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Schwanke CH, da Cruz IB, Leal NF, Scheibe R, Moriguchi Y and Moriguchi EH: Analysis of the association between apolipoprotein E polymorphism and cardiovascular risk factors in an elderly population with longevity. Arq Bras Cardiol. 78:561–570. 2002.(In English, Portuguese).

34 

Souza D, Campos BF, Arruda EF, Yamamoto LJ, Trindade DM and Tognola WA: Influence of the polymorphism of apolipoprotein E in cerebral vascular disease. Arq Neuropsiquiatr. 61:7–13. 2003. View Article : Google Scholar : PubMed/NCBI

35 

McNamara JJ, Molot M, Dunn R, Burran EL and Stremple JF: Lipid metabolism after trauma. Role in the pathogenesis of fat embolism. J Thoracic Cardiovasc Surg. 63:968–972. 1972.PubMed/NCBI

36 

Morales M, Santana N, Soria A, Soria A, Mosquera A, Ordovás J, Nóvoa J, Betancor P, Valerón PF, Díaz-Chico B and Chirino R: Effects of tamoxifen on serum lipid and apolipoprotein levels in postmenopausal patients with breast cancer. Breast Cancer Res Treat. 49:265–270. 1996. View Article : Google Scholar : PubMed/NCBI

37 

Instituto Nacional de Câncer José Alencar Gomes da Silva. Coordenação de Prevenção e Vigilância Estimativa 2014. Incidência de Câncer no Brasil/Instituto Nacional de Câncer José Alencar Gomes da Silva Coordenação de Prevenção e Vigilância Rio de Janeiro: INCA; pp. 922014

38 

Fuchs FD: Systemic arterial hypertension. Epidemiology and risk factors. Arq Bras Cardiol. 63:443–444. 1994.(In Portuguese).

39 

Duncan BB, Schimidt MI, Polanczyk CA, Hormrich CS, Rosa RS and Achutti AC: Risk factors for non-communicable diseases in a metropolitan area in the south of Brazil. Prevalence and simultaneity. Rev Saude Publica. 27:43–48. 1993.(In Portuguese).

40 

Gus I, Fischmann A and Medina C: Prevalência dos fatores de risco da doença arterial coronariana no Estado do Rio Grande do Sul. Arq Bras Cardiol. 78:478–483. 2002.(In Portuguese).

41 

Davignon J, Gregg RE and Sing CF: Apolipoprotein E polymorphism and atherosclerosis. Arterioscler Thromb Vasc Biol. 8:1–21. 1988. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Cibeira GH, Giacomazzi J, Aguiar E, Schneider S, Ettrich B, Isoppo De Souza C, Camey S, Caleffi M, Weber B, Ashton-Prolla P, Ashton-Prolla P, et al: Apolipoprotein E genetic polymorphism, serum lipoprotein levels and breast cancer risk: A case-control study. Mol Clin Oncol 2: 1009-1015, 2014.
APA
Cibeira, G.H., Giacomazzi, J., Aguiar, E., Schneider, S., Ettrich, B., Isoppo De Souza, C. ... Moriguchi, E.H. (2014). Apolipoprotein E genetic polymorphism, serum lipoprotein levels and breast cancer risk: A case-control study. Molecular and Clinical Oncology, 2, 1009-1015. https://doi.org/10.3892/mco.2014.369
MLA
Cibeira, G. H., Giacomazzi, J., Aguiar, E., Schneider, S., Ettrich, B., Isoppo De Souza, C., Camey, S., Caleffi, M., Weber, B., Ashton-Prolla, P., Moriguchi, E. H."Apolipoprotein E genetic polymorphism, serum lipoprotein levels and breast cancer risk: A case-control study". Molecular and Clinical Oncology 2.6 (2014): 1009-1015.
Chicago
Cibeira, G. H., Giacomazzi, J., Aguiar, E., Schneider, S., Ettrich, B., Isoppo De Souza, C., Camey, S., Caleffi, M., Weber, B., Ashton-Prolla, P., Moriguchi, E. H."Apolipoprotein E genetic polymorphism, serum lipoprotein levels and breast cancer risk: A case-control study". Molecular and Clinical Oncology 2, no. 6 (2014): 1009-1015. https://doi.org/10.3892/mco.2014.369
Copy and paste a formatted citation
x
Spandidos Publications style
Cibeira GH, Giacomazzi J, Aguiar E, Schneider S, Ettrich B, Isoppo De Souza C, Camey S, Caleffi M, Weber B, Ashton-Prolla P, Ashton-Prolla P, et al: Apolipoprotein E genetic polymorphism, serum lipoprotein levels and breast cancer risk: A case-control study. Mol Clin Oncol 2: 1009-1015, 2014.
APA
Cibeira, G.H., Giacomazzi, J., Aguiar, E., Schneider, S., Ettrich, B., Isoppo De Souza, C. ... Moriguchi, E.H. (2014). Apolipoprotein E genetic polymorphism, serum lipoprotein levels and breast cancer risk: A case-control study. Molecular and Clinical Oncology, 2, 1009-1015. https://doi.org/10.3892/mco.2014.369
MLA
Cibeira, G. H., Giacomazzi, J., Aguiar, E., Schneider, S., Ettrich, B., Isoppo De Souza, C., Camey, S., Caleffi, M., Weber, B., Ashton-Prolla, P., Moriguchi, E. H."Apolipoprotein E genetic polymorphism, serum lipoprotein levels and breast cancer risk: A case-control study". Molecular and Clinical Oncology 2.6 (2014): 1009-1015.
Chicago
Cibeira, G. H., Giacomazzi, J., Aguiar, E., Schneider, S., Ettrich, B., Isoppo De Souza, C., Camey, S., Caleffi, M., Weber, B., Ashton-Prolla, P., Moriguchi, E. H."Apolipoprotein E genetic polymorphism, serum lipoprotein levels and breast cancer risk: A case-control study". Molecular and Clinical Oncology 2, no. 6 (2014): 1009-1015. https://doi.org/10.3892/mco.2014.369
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