Predominance of ERG‑negative high‑grade prostate cancers in African American men

  • Authors:
    • James Farrell
    • Denise Young
    • Yongmei Chen
    • Jennifer Cullen
    • Inger L. Rosner
    • Jacob Kagan
    • Sudhir Srivastava
    • David G. McLeod
    • Isabell A. Sesterhenn
    • Shiv Srivastava
    • Gyorgy Petrovics
  • View Affiliations

  • Published online on: August 7, 2014     https://doi.org/10.3892/mco.2014.378
  • Pages: 982-986
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Abstract

Erythroblast transformation-specific‑related gene (ERG) fusions, the most common and validated prostate cancer (CaP) genome alteration, result in alterations in the expression of the ERG oncoprotein. Significantly lower frequencies of ERG have been reported in tumors of African American (AA) in comparison to Caucasian American (CA) men. Building on our preliminary observations, this study has focused on the increased association of the ERG‑negative status with higher‑grade prostate tumors in AA men. Representative whole‑mount prostate sections from a matched cohort of 63 AA and 63 CA men with Gleason scores of 4+3 and those with Gleason scores of 8‑10 were analyzed for ERG oncoprotein by immunohistochemistry. The striking finding of this study was that ERG expression was 3 times more likely to be present in the higher‑grade index tumors of CA men compared to AA men (31 of 63 vs. 10 of 63 patients, respectively; P<0.0001). Although the mechanisms underlying these differences have not been elucidated, the present study along with our previous observations underscores that ERG typing may enhance the understanding of ethnic differences and future targeted therapy of CaP.
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November-December 2014
Volume 2 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Farrell J, Young D, Chen Y, Cullen J, Rosner IL, Kagan J, Srivastava S, McLeod DG, Sesterhenn IA, Srivastava S, Srivastava S, et al: Predominance of ERG‑negative high‑grade prostate cancers in African American men. Mol Clin Oncol 2: 982-986, 2014
APA
Farrell, J., Young, D., Chen, Y., Cullen, J., Rosner, I.L., Kagan, J. ... Petrovics, G. (2014). Predominance of ERG‑negative high‑grade prostate cancers in African American men. Molecular and Clinical Oncology, 2, 982-986. https://doi.org/10.3892/mco.2014.378
MLA
Farrell, J., Young, D., Chen, Y., Cullen, J., Rosner, I. L., Kagan, J., Srivastava, S., McLeod, D. G., Sesterhenn, I. A., Srivastava, S., Petrovics, G."Predominance of ERG‑negative high‑grade prostate cancers in African American men". Molecular and Clinical Oncology 2.6 (2014): 982-986.
Chicago
Farrell, J., Young, D., Chen, Y., Cullen, J., Rosner, I. L., Kagan, J., Srivastava, S., McLeod, D. G., Sesterhenn, I. A., Srivastava, S., Petrovics, G."Predominance of ERG‑negative high‑grade prostate cancers in African American men". Molecular and Clinical Oncology 2, no. 6 (2014): 982-986. https://doi.org/10.3892/mco.2014.378