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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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November-December 2014 Volume 2 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Predominance of ERG‑negative high‑grade prostate cancers in African American men

  • Authors:
    • James Farrell
    • Denise Young
    • Yongmei Chen
    • Jennifer Cullen
    • Inger L. Rosner
    • Jacob Kagan
    • Sudhir Srivastava
    • David G. McLeod
    • Isabell A. Sesterhenn
    • Shiv Srivastava
    • Gyorgy Petrovics

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA, Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, Department of Genitourinary Pathology, Joint Pathology Center, Silver Spring, MD 20910‑1290, USA
  • Pages: 982-986
    |
    Published online on: August 7, 2014
       https://doi.org/10.3892/mco.2014.378
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Abstract

Erythroblast transformation-specific‑related gene (ERG) fusions, the most common and validated prostate cancer (CaP) genome alteration, result in alterations in the expression of the ERG oncoprotein. Significantly lower frequencies of ERG have been reported in tumors of African American (AA) in comparison to Caucasian American (CA) men. Building on our preliminary observations, this study has focused on the increased association of the ERG‑negative status with higher‑grade prostate tumors in AA men. Representative whole‑mount prostate sections from a matched cohort of 63 AA and 63 CA men with Gleason scores of 4+3 and those with Gleason scores of 8‑10 were analyzed for ERG oncoprotein by immunohistochemistry. The striking finding of this study was that ERG expression was 3 times more likely to be present in the higher‑grade index tumors of CA men compared to AA men (31 of 63 vs. 10 of 63 patients, respectively; P<0.0001). Although the mechanisms underlying these differences have not been elucidated, the present study along with our previous observations underscores that ERG typing may enhance the understanding of ethnic differences and future targeted therapy of CaP.
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Copy and paste a formatted citation
Spandidos Publications style
Farrell J, Young D, Chen Y, Cullen J, Rosner IL, Kagan J, Srivastava S, McLeod DG, Sesterhenn IA, Srivastava S, Srivastava S, et al: Predominance of ERG‑negative high‑grade prostate cancers in African American men. Mol Clin Oncol 2: 982-986, 2014.
APA
Farrell, J., Young, D., Chen, Y., Cullen, J., Rosner, I.L., Kagan, J. ... Petrovics, G. (2014). Predominance of ERG‑negative high‑grade prostate cancers in African American men. Molecular and Clinical Oncology, 2, 982-986. https://doi.org/10.3892/mco.2014.378
MLA
Farrell, J., Young, D., Chen, Y., Cullen, J., Rosner, I. L., Kagan, J., Srivastava, S., McLeod, D. G., Sesterhenn, I. A., Srivastava, S., Petrovics, G."Predominance of ERG‑negative high‑grade prostate cancers in African American men". Molecular and Clinical Oncology 2.6 (2014): 982-986.
Chicago
Farrell, J., Young, D., Chen, Y., Cullen, J., Rosner, I. L., Kagan, J., Srivastava, S., McLeod, D. G., Sesterhenn, I. A., Srivastava, S., Petrovics, G."Predominance of ERG‑negative high‑grade prostate cancers in African American men". Molecular and Clinical Oncology 2, no. 6 (2014): 982-986. https://doi.org/10.3892/mco.2014.378
Copy and paste a formatted citation
x
Spandidos Publications style
Farrell J, Young D, Chen Y, Cullen J, Rosner IL, Kagan J, Srivastava S, McLeod DG, Sesterhenn IA, Srivastava S, Srivastava S, et al: Predominance of ERG‑negative high‑grade prostate cancers in African American men. Mol Clin Oncol 2: 982-986, 2014.
APA
Farrell, J., Young, D., Chen, Y., Cullen, J., Rosner, I.L., Kagan, J. ... Petrovics, G. (2014). Predominance of ERG‑negative high‑grade prostate cancers in African American men. Molecular and Clinical Oncology, 2, 982-986. https://doi.org/10.3892/mco.2014.378
MLA
Farrell, J., Young, D., Chen, Y., Cullen, J., Rosner, I. L., Kagan, J., Srivastava, S., McLeod, D. G., Sesterhenn, I. A., Srivastava, S., Petrovics, G."Predominance of ERG‑negative high‑grade prostate cancers in African American men". Molecular and Clinical Oncology 2.6 (2014): 982-986.
Chicago
Farrell, J., Young, D., Chen, Y., Cullen, J., Rosner, I. L., Kagan, J., Srivastava, S., McLeod, D. G., Sesterhenn, I. A., Srivastava, S., Petrovics, G."Predominance of ERG‑negative high‑grade prostate cancers in African American men". Molecular and Clinical Oncology 2, no. 6 (2014): 982-986. https://doi.org/10.3892/mco.2014.378
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