Association of xeroderma pigmentosum complementation group G Asp1104His polymorphism with breast cancer risk: A cumulative meta‑analysis

Xu,Xiao‑Ming; Xie,Long‑Chuan; Yuan,Ling‑Ling; Hu,Xiao‑Li; Jin,Jian‑Qiang; Niu,Yu‑Ming

doi:10.3892/mco.2014.384

Association of xeroderma pigmentosum complementation group G Asp1104His polymorphism with breast cancer risk: A cumulative meta‑analysis

Authors:
- Xiao‑Ming Xu
- Long‑Chuan Xie
- Ling‑Ling Yuan
- Xiao‑Li Hu
- Jian‑Qiang Jin
- Yu‑Ming Niu
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Affiliations: Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Department of Pathology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Department of Pathology, The Fourth Affiliated Hospital of Soochow University, Wuxi, Jiangsu 214062, P.R. China
Published online on: August 11, 2014 https://doi.org/10.3892/mco.2014.384
Pages: 1177-1181

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Abstract

The xeroderma pigmentosum complementation group G (XPG) gene plays an important role in the DNA nucleotide excision repair (NER) pathway. Several studies have investigated the association between the XPG Asp1104His polymorphism and breast cancer; however, the results have been inconsistent. therefore, we conducted a meta‑analysis of 8 published articles (10 case‑control studies) including a total of 5,235 patients with breast cancer and 5,685 healthy controls. The results demonstrated that the XPG Asp1104His polymorphism was not associated with breast cancer in the overall population [His vs. Asp, odds ratio (OR)=1.00, 95% confidence interval (CI): 0.91‑1.08; His/His vs. Asp/Asp, OR=0.96, 95% CI: 0.83‑1.11; Asp/His vs. Asp/Asp, OR=1.02, 95% CI: 0.94‑1.11; His/His+Asp/His vs. Asp/Asp, OR=1.03, 95% CI: 0.92‑1.15; and His/His vs. Asp/Asp+Asp/His, OR=0.93, 95% CI: 0.81‑1.06]. In the subgroup analysis by ethnicity, no significant association was observed in European subjects. In conclusion, this meta‑analysis suggested that the XPG Asp1104His polymorphism is not associated with breast cancer risk.

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1	Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar
2	Conlon MS, Johnson KC, Bewick MA, Lafrenie RM and Donner A: Smoking (active and passive), N-acetyltransferase 2, and risk of breast cancer. Cancer Epidemiol. 34:142–149. 2010. View Article : Google Scholar : PubMed/NCBI
3	Beasley JM, Coronado GD, Livaudais J, et al: Alcohol and risk of breast cancer in Mexican women. Cancer Causes Control. 21:863–870. 2010. View Article : Google Scholar : PubMed/NCBI
4	Thorel F, Constantinou A, Dunand-Sauthier I, et al: Definition of a short region of XPG necessary for TFIIH interaction and stable recruitment to sites of UV damage. Mol Cell Biol. 24:10670–10680. 2004. View Article : Google Scholar : PubMed/NCBI
5	Collins A and Harrington V: Repair of oxidative DNA damage: assessing its contribution to cancer prevention. Mutagenesis. 17:489–493. 2002. View Article : Google Scholar : PubMed/NCBI
6	Berwick M and Vineis P: Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review. J Natl Cancer Inst. 92:874–897. 2000. View Article : Google Scholar
7	Kiyohara C and Yoshimasu K: Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: a meta-analysis. Int J Med Sci. 4:59–71. 2007. View Article : Google Scholar : PubMed/NCBI
8	Sanyal S, Festa F, Sakano S, et al: Polymorphisms in DNA repair and metabolic genes in bladder cancer. Carcinogenesis. 25:729–734. 2004. View Article : Google Scholar : PubMed/NCBI
9	Sobti RC, Berhane N, Mehedi SA, et al: Association and impact of XPG Asp 1104 His gene polymorphism in HIV 1 disease progression to AIDS among north Indian HIV seropositive individuals. Mol Biol Rep. 37:317–324. 2010. View Article : Google Scholar : PubMed/NCBI
10	Kumar R, Hoglund L, Zhao C, Forsti A, Snellman E and Hemminki K: Single nucleotide polymorphisms in the XPG gene: determination of role in DNA repair and breast cancer risk. Int J Cancer. 103:671–675. 2003. View Article : Google Scholar : PubMed/NCBI
11	Little J, Bradley L, Bray MS, et al: Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations. Am J Epidemiol. 156:300–310. 2002. View Article : Google Scholar : PubMed/NCBI
12	Lau J, Ioannidis JP and Schmid CH: Quantitative synthesis in systematic reviews. Ann Intern Med. 127:820–826. 1997. View Article : Google Scholar : PubMed/NCBI
13	DerSimonian R and Laird N: Meta-analysis in clinical trials. Control Clin Trials. 7:177–188. 1986. View Article : Google Scholar : PubMed/NCBI
14	Mantel N and Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 22:719–748. 1959.PubMed/NCBI
15	Egger M, Davey Smith G, Schneider M and Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–634. 1997. View Article : Google Scholar : PubMed/NCBI
16	Mechanic LE, Millikan RC, Player J, et al: Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study. Carcinogenesis. 27:1377–1385. 2006. View Article : Google Scholar : PubMed/NCBI
17	Shen J, Desai M, Agrawal M, et al: Polymorphisms in nucleotide excision repair genes and DNA repair capacity phenotype in sisters discordant for breast cancer. Cancer Epidemiol Biomarkers Prev. 15:1614–1619. 2006. View Article : Google Scholar : PubMed/NCBI
18	Crew KD, Gammon MD, Terry MB, et al: Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 16:2033–2041. 2007. View Article : Google Scholar : PubMed/NCBI
19	Jorgensen TJ, Visvanathan K, Ruczinski I, Thuita L, Hoffman S and Helzlsouer KJ: Breast cancer risk is not associated with polymorphic forms of xeroderma pigmentosum genes in a cohort of women from Washington County, Maryland. Breast Cancer Res Treat. 101:65–71. 2007. View Article : Google Scholar : PubMed/NCBI
20	Rajaraman P, Bhatti P, Doody MM, et al: Nucleotide excision repair polymorphisms may modify ionizing radiation-related breast cancer risk in US radiologic technologists. Int J Cancer. 123:2713–2716. 2008. View Article : Google Scholar : PubMed/NCBI
21	Smith TR, Levine EA, Freimanis RI, et al: Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. Carcinogenesis. 29:2132–2138. 2008. View Article : Google Scholar : PubMed/NCBI
22	Ming-Shiean H, Yu JC, Wang HW, et al: Synergistic effects of polymorphisms in DNA repair genes and endogenous estrogen exposure on female breast cancer risk. Ann Surg Oncol. 17:760–771. 2010. View Article : Google Scholar : PubMed/NCBI
23	Harrington JJ and Lieber MR: Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair. Genes Dev. 8:1344–1355. 1994. View Article : Google Scholar
24	Matsunaga T, Park CH, Bessho T, Mu D and Sancar A: Replication protein A confers structure-specific endonuclease activities to the XPF-ERCC1 and XPG subunits of human DNA repair excision nuclease. J Biol Chem. 271:11047–11050. 1996. View Article : Google Scholar
25	Bessho T: Nucleotide excision repair 3′ endonuclease XPG stimulates the activity of base excision repair enzyme thymine glycol DNA glycosylase. Nucleic Acids Res. 27:979–983. 1999.
26	Fagbemi AF, Orelli B and Scharer OD: Regulation of endonuclease activity in human nucleotide excision repair. DNA Repair (Amst). 10:722–729. 2011. View Article : Google Scholar : PubMed/NCBI
27	Chang JS, Wrensch MR, Hansen HM, et al: Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans. Int J Cancer. 123:2095–2104. 2008. View Article : Google Scholar
28	Biason P, Hattinger CM, Innocenti F, et al: Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy. Pharmacogenomics J. 12:476–483. 2012. View Article : Google Scholar : PubMed/NCBI