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Article

Association of xeroderma pigmentosum complementation group G Asp1104His polymorphism with breast cancer risk: A cumulative meta‑analysis

  • Authors:
    • Xiao‑Ming Xu
    • Long‑Chuan Xie
    • Ling‑Ling Yuan
    • Xiao‑Li Hu
    • Jian‑Qiang Jin
    • Yu‑Ming Niu
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Department of Pathology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Department of Pathology, The Fourth Affiliated Hospital of Soochow University, Wuxi, Jiangsu 214062, P.R. China
  • Pages: 1177-1181
    |
    Published online on: August 11, 2014
       https://doi.org/10.3892/mco.2014.384
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Abstract

The xeroderma pigmentosum complementation group G (XPG) gene plays an important role in the DNA nucleotide excision repair (NER) pathway. Several studies have investigated the association between the XPG Asp1104His polymorphism and breast cancer; however, the results have been inconsistent. therefore, we conducted a meta‑analysis of 8 published articles (10 case‑control studies) including a total of 5,235 patients with breast cancer and 5,685 healthy controls. The results demonstrated that the XPG Asp1104His polymorphism was not associated with breast cancer in the overall population [His vs. Asp, odds ratio (OR)=1.00, 95% confidence interval (CI): 0.91‑1.08; His/His vs. Asp/Asp, OR=0.96, 95% CI: 0.83‑1.11; Asp/His vs. Asp/Asp, OR=1.02, 95% CI: 0.94‑1.11; His/His+Asp/His vs. Asp/Asp, OR=1.03, 95% CI: 0.92‑1.15; and His/His vs. Asp/Asp+Asp/His, OR=0.93, 95% CI: 0.81‑1.06]. In the subgroup analysis by ethnicity, no significant association was observed in European subjects. In conclusion, this meta‑analysis suggested that the XPG Asp1104His polymorphism is not associated with breast cancer risk.
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Copy and paste a formatted citation
Spandidos Publications style
Xu XM, Xie LC, Yuan LL, Hu XL, Jin JQ and Niu YM: Association of xeroderma pigmentosum complementation group G Asp1104His polymorphism with breast cancer risk: A cumulative meta‑analysis. Mol Clin Oncol 2: 1177-1181, 2014.
APA
Xu, X., Xie, L., Yuan, L., Hu, X., Jin, J., & Niu, Y. (2014). Association of xeroderma pigmentosum complementation group G Asp1104His polymorphism with breast cancer risk: A cumulative meta‑analysis. Molecular and Clinical Oncology, 2, 1177-1181. https://doi.org/10.3892/mco.2014.384
MLA
Xu, X., Xie, L., Yuan, L., Hu, X., Jin, J., Niu, Y."Association of xeroderma pigmentosum complementation group G Asp1104His polymorphism with breast cancer risk: A cumulative meta‑analysis". Molecular and Clinical Oncology 2.6 (2014): 1177-1181.
Chicago
Xu, X., Xie, L., Yuan, L., Hu, X., Jin, J., Niu, Y."Association of xeroderma pigmentosum complementation group G Asp1104His polymorphism with breast cancer risk: A cumulative meta‑analysis". Molecular and Clinical Oncology 2, no. 6 (2014): 1177-1181. https://doi.org/10.3892/mco.2014.384
Copy and paste a formatted citation
x
Spandidos Publications style
Xu XM, Xie LC, Yuan LL, Hu XL, Jin JQ and Niu YM: Association of xeroderma pigmentosum complementation group G Asp1104His polymorphism with breast cancer risk: A cumulative meta‑analysis. Mol Clin Oncol 2: 1177-1181, 2014.
APA
Xu, X., Xie, L., Yuan, L., Hu, X., Jin, J., & Niu, Y. (2014). Association of xeroderma pigmentosum complementation group G Asp1104His polymorphism with breast cancer risk: A cumulative meta‑analysis. Molecular and Clinical Oncology, 2, 1177-1181. https://doi.org/10.3892/mco.2014.384
MLA
Xu, X., Xie, L., Yuan, L., Hu, X., Jin, J., Niu, Y."Association of xeroderma pigmentosum complementation group G Asp1104His polymorphism with breast cancer risk: A cumulative meta‑analysis". Molecular and Clinical Oncology 2.6 (2014): 1177-1181.
Chicago
Xu, X., Xie, L., Yuan, L., Hu, X., Jin, J., Niu, Y."Association of xeroderma pigmentosum complementation group G Asp1104His polymorphism with breast cancer risk: A cumulative meta‑analysis". Molecular and Clinical Oncology 2, no. 6 (2014): 1177-1181. https://doi.org/10.3892/mco.2014.384
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