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Article

p16 promoter hypermethylation is associated with increased risk of nasopharyngeal carcinoma

  • Authors:
    • Yang Shao
    • Hongguo Jiang
    • Xiaoming Wu
    • Ying Luo
    • Wenru Tang
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China, Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China
  • Pages: 1121-1124
    |
    Published online on: August 20, 2014
       https://doi.org/10.3892/mco.2014.396
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Abstract

The present study aimed to investigate the effects of p16 hypermethylation on the risk of nasopharyngeal carcinoma (NPC) quantitatively, through a meta‑analysis of available case‑control studies including malignant and normal NPC tissue samples. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and pooled to assess the strength of the association between p16 hypermethylation and NPC risk. A total of 9 studies, including 406 NPC and 376 control cases, were identified for meta‑analysis. Statistically significant ORs of p16 hypermethylation were obtained from the NPC and control groups (OR=19.53; 95% CI: 9.54‑39.97; P=0.685). The meta‑analysis indicated that p16 hypermethylation significantly increases NPC risk.
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Copy and paste a formatted citation
Spandidos Publications style
Shao Y, Jiang H, Wu X, Luo Y and Tang W: p16 promoter hypermethylation is associated with increased risk of nasopharyngeal carcinoma. Mol Clin Oncol 2: 1121-1124, 2014.
APA
Shao, Y., Jiang, H., Wu, X., Luo, Y., & Tang, W. (2014). p16 promoter hypermethylation is associated with increased risk of nasopharyngeal carcinoma. Molecular and Clinical Oncology, 2, 1121-1124. https://doi.org/10.3892/mco.2014.396
MLA
Shao, Y., Jiang, H., Wu, X., Luo, Y., Tang, W."p16 promoter hypermethylation is associated with increased risk of nasopharyngeal carcinoma". Molecular and Clinical Oncology 2.6 (2014): 1121-1124.
Chicago
Shao, Y., Jiang, H., Wu, X., Luo, Y., Tang, W."p16 promoter hypermethylation is associated with increased risk of nasopharyngeal carcinoma". Molecular and Clinical Oncology 2, no. 6 (2014): 1121-1124. https://doi.org/10.3892/mco.2014.396
Copy and paste a formatted citation
x
Spandidos Publications style
Shao Y, Jiang H, Wu X, Luo Y and Tang W: p16 promoter hypermethylation is associated with increased risk of nasopharyngeal carcinoma. Mol Clin Oncol 2: 1121-1124, 2014.
APA
Shao, Y., Jiang, H., Wu, X., Luo, Y., & Tang, W. (2014). p16 promoter hypermethylation is associated with increased risk of nasopharyngeal carcinoma. Molecular and Clinical Oncology, 2, 1121-1124. https://doi.org/10.3892/mco.2014.396
MLA
Shao, Y., Jiang, H., Wu, X., Luo, Y., Tang, W."p16 promoter hypermethylation is associated with increased risk of nasopharyngeal carcinoma". Molecular and Clinical Oncology 2.6 (2014): 1121-1124.
Chicago
Shao, Y., Jiang, H., Wu, X., Luo, Y., Tang, W."p16 promoter hypermethylation is associated with increased risk of nasopharyngeal carcinoma". Molecular and Clinical Oncology 2, no. 6 (2014): 1121-1124. https://doi.org/10.3892/mco.2014.396
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