Vascular invasion affects survival in early hepatocellular carcinoma

Hsieh,Chen‑Hsi; Wei,Chang‑Kuo; Yin,Wen‑Yao; Chang,Chun‑Ming; Tsai,Shiang‑Jiun; Wang,Li‑Ying; Chiou,Wen‑Yen; Lee,Moon‑Sing; Lin,Hon‑Yi; Hung,Shih‑Kai

doi:10.3892/mco.2014.420

January-February 2015 Volume 3 Issue 1

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January-February 2015 Volume 3 Issue 1

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Article

Vascular invasion affects survival in early hepatocellular carcinoma

Authors:
- Chen‑Hsi Hsieh
- Chang‑Kuo Wei
- Wen‑Yao Yin
- Chun‑Ming Chang
- Shiang‑Jiun Tsai
- Li‑Ying Wang
- Wen‑Yen Chiou
- Moon‑Sing Lee
- Hon‑Yi Lin
- Shih‑Kai Hung
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Affiliations: Department of Radiation Oncology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan, R.O.C., Department of General Surgery, Buddhist Dalin Tzu Chi Hospital, Dalin, Chiayi 62247, Taiwan, R.O.C., Department of Radiation Oncology, Buddhist Dalin Tzu Chi Hospital, Dalin, Chiayi 62247, Taiwan, R.O.C., School and Graduate Institute of Physical Therapy, College of Medicine, Taipei City 100, Taiwan, R.O.C.
Pages: 252-256
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Published online on: September 18, 2014

https://doi.org/10.3892/mco.2014.420
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Abstract

Hepatocellular carcinoma (HCC) is an aggressive malignant tumor with a high mortality rate. The optimal therapeutic choice for early HCC is surgical resection. However, the rate of intrahepatic recurrence is high. The objective of this study was to evaluate the effect of various factors on the survival of patients with early HCC. Between January 1st, 2006 and December 31st, 2013, a total of 89 patients who underwent surgery for HCC were retrospectively enrolled. The analysis was conducted using the Student's t‑test, Chi‑square test, Kaplan‑Meier method and Cox proportional hazard regression model to assess potential confounding and predictive variables. The 3‑year overall survival (OS) rate was 71%. The 3‑year OS rates in patients with and those without vascular invasion were 62.1 and 92.8%, respectively (p<0.003). Based on the multivariate analysis, postoperative pathological vascular invasion (hazard ratio = 4.96; 95% confidence interval: 1.55‑15.9) remained an independent predictor of adverse long‑term outcome. Furthermore, vascular invasion was significantly associated with intrahepatic metastasis. These data emphasize the need for effective adjuvant therapy in selected high‑risk patients with early HCC. Further studies are required to determine the optimal approach to further improving the prognosis of early HCC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Vascular invasion affects survival in early hepatocellular carcinoma

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Abstract

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