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Article

Indirect comparison of the efficacy and safety of gefitinib and cetuximab‑based therapy in patients with advanced non‑small‑cell lung cancer

  • Authors:
    • Jifeng Tang
    • Hena Zhang
    • Jianzhou Yan
    • Rong Shao
  • View Affiliations / Copyright

    Affiliations: The Research Center of National Drug Policy and Ecosystem, Nanjing, Jiangsu 211198, P.R. China
  • Pages: 145-150
    |
    Published online on: September 22, 2014
       https://doi.org/10.3892/mco.2014.424
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Abstract

The aim of this study was to systematically evaluate the efficacy and safety of gefitinib and cetuximab‑based therapies in patients with advanced non‑small‑cell lung cancer (NSCLC). The studies to be used for the comparisons were selected from the available literature on gefitinib and cetuximab‑based therapies compared to conventional chemotherapy in patients with advanced NSCLC. The meta‑analysis was performed with RevMan 5.0 software and the Bucher approach was applied to conduct the indirect comparisons. A total of 4 studies, including 935 patients, on gefitinib therapy vs. conventional chemotherapy and 4 studies, including 1,015 patients, on cetuximab‑based therapy vs. conventional chemotherapy, were used for indirect comparisons. As regards efficacy, the risk ratio (RR) of objective response rate and 1‑year survival rate between gefitinib and cetuximab‑based therapies in patients with advanced NSCLC were 0.99 [95% confidence interval (CI): 0.75‑1.32; p=0.9584] and 0.85 (95% CI: 0.71‑1.01; p=0.0696), respectively, and the mean difference of progression‑free survival and overall survival (OS) were ‑0.15 (95% CI: ‑0.90 to 0.60; p=0.6946) and ‑1.84 (95% CI: ‑3.53 to ‑0.15; p=0.0331), respectively. As regards safety, the RR of grade 3/4 adverse events (AEs) was 0.29 (95% CI: 0.19‑0.44; p=0.0001). The results demonstrated that cetuximab‑based therapy was superior to gefitinib therapy in terms of OS and inferior to gefitinib therapy in terms of AEs, whereas there were no significant differences in terms of efficacy and safety between the two therapies on other endpoints adopted for advanced NSCLC. However, further well‑designed randomized controlled trials and continuous studies are required to confirm our findings.
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Copy and paste a formatted citation
Spandidos Publications style
Tang J, Zhang H, Yan J and Shao R: Indirect comparison of the efficacy and safety of gefitinib and cetuximab‑based therapy in patients with advanced non‑small‑cell lung cancer. Mol Clin Oncol 3: 145-150, 2015.
APA
Tang, J., Zhang, H., Yan, J., & Shao, R. (2015). Indirect comparison of the efficacy and safety of gefitinib and cetuximab‑based therapy in patients with advanced non‑small‑cell lung cancer. Molecular and Clinical Oncology, 3, 145-150. https://doi.org/10.3892/mco.2014.424
MLA
Tang, J., Zhang, H., Yan, J., Shao, R."Indirect comparison of the efficacy and safety of gefitinib and cetuximab‑based therapy in patients with advanced non‑small‑cell lung cancer". Molecular and Clinical Oncology 3.1 (2015): 145-150.
Chicago
Tang, J., Zhang, H., Yan, J., Shao, R."Indirect comparison of the efficacy and safety of gefitinib and cetuximab‑based therapy in patients with advanced non‑small‑cell lung cancer". Molecular and Clinical Oncology 3, no. 1 (2015): 145-150. https://doi.org/10.3892/mco.2014.424
Copy and paste a formatted citation
x
Spandidos Publications style
Tang J, Zhang H, Yan J and Shao R: Indirect comparison of the efficacy and safety of gefitinib and cetuximab‑based therapy in patients with advanced non‑small‑cell lung cancer. Mol Clin Oncol 3: 145-150, 2015.
APA
Tang, J., Zhang, H., Yan, J., & Shao, R. (2015). Indirect comparison of the efficacy and safety of gefitinib and cetuximab‑based therapy in patients with advanced non‑small‑cell lung cancer. Molecular and Clinical Oncology, 3, 145-150. https://doi.org/10.3892/mco.2014.424
MLA
Tang, J., Zhang, H., Yan, J., Shao, R."Indirect comparison of the efficacy and safety of gefitinib and cetuximab‑based therapy in patients with advanced non‑small‑cell lung cancer". Molecular and Clinical Oncology 3.1 (2015): 145-150.
Chicago
Tang, J., Zhang, H., Yan, J., Shao, R."Indirect comparison of the efficacy and safety of gefitinib and cetuximab‑based therapy in patients with advanced non‑small‑cell lung cancer". Molecular and Clinical Oncology 3, no. 1 (2015): 145-150. https://doi.org/10.3892/mco.2014.424
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