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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Prognostic value of osteopontin expression in breast cancer: A meta-analysis

  • Authors:
    • Ying-Yi Xu
    • Ya-Ya Zhang
    • Wei-Feng Lu
    • Yan-Jun Mi
    • Yu-Qiang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Chenggong Hospital Affiliated to Xiamen University, No. 174 Hospital of People's Liberation Army, Xiamen 361003, P.R. China, Department of Vascular Surgery, Zhongshan Hospital, Xiamen 361003, P.R. China
  • Pages: 357-362
    |
    Published online on: December 22, 2014
       https://doi.org/10.3892/mco.2014.480
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Abstract

Osteopontin (OPN) has been implicated in tumor development and progression over the last few years. However, the prognostic value of OPN overexpression in patients with breast cancer remains controversial. We performed a meta‑analysis to investigate the association of OPN expression in the tumor with the clinicopathological characteristics and survival of breast cancer patients. A total of 8 studies met the inclusion criteria and were entered in the meta‑analysis. The data analysis demonstrated that OPN expression was positively associated with lymph node metastasis [pooled odds ratio = 2.026, 95% confidence interval (CI): 1.199‑3.425, P=0.008, random‑effects model]. we also found that OPN expression was positively associated with overall survival [hazard ratio (HR) = 3.69, 95% CI: 1.45‑9.42, P=0.000, random‑effects model) and disease‑free survival (pooled HR=2.40, 95% CI: 1.27‑4.55, P=0.007, fixed‑effects model). Based on the results of this study, we concluded that OPN overexpression in the tumor is a candidate positive prognostic biomarker for breast cancer patients.
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Copy and paste a formatted citation
Spandidos Publications style
Xu Y, Zhang Y, Lu W, Mi Y and Chen Y: Prognostic value of osteopontin expression in breast cancer: A meta-analysis. Mol Clin Oncol 3: 357-362, 2015.
APA
Xu, Y., Zhang, Y., Lu, W., Mi, Y., & Chen, Y. (2015). Prognostic value of osteopontin expression in breast cancer: A meta-analysis. Molecular and Clinical Oncology, 3, 357-362. https://doi.org/10.3892/mco.2014.480
MLA
Xu, Y., Zhang, Y., Lu, W., Mi, Y., Chen, Y."Prognostic value of osteopontin expression in breast cancer: A meta-analysis". Molecular and Clinical Oncology 3.2 (2015): 357-362.
Chicago
Xu, Y., Zhang, Y., Lu, W., Mi, Y., Chen, Y."Prognostic value of osteopontin expression in breast cancer: A meta-analysis". Molecular and Clinical Oncology 3, no. 2 (2015): 357-362. https://doi.org/10.3892/mco.2014.480
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Y, Zhang Y, Lu W, Mi Y and Chen Y: Prognostic value of osteopontin expression in breast cancer: A meta-analysis. Mol Clin Oncol 3: 357-362, 2015.
APA
Xu, Y., Zhang, Y., Lu, W., Mi, Y., & Chen, Y. (2015). Prognostic value of osteopontin expression in breast cancer: A meta-analysis. Molecular and Clinical Oncology, 3, 357-362. https://doi.org/10.3892/mco.2014.480
MLA
Xu, Y., Zhang, Y., Lu, W., Mi, Y., Chen, Y."Prognostic value of osteopontin expression in breast cancer: A meta-analysis". Molecular and Clinical Oncology 3.2 (2015): 357-362.
Chicago
Xu, Y., Zhang, Y., Lu, W., Mi, Y., Chen, Y."Prognostic value of osteopontin expression in breast cancer: A meta-analysis". Molecular and Clinical Oncology 3, no. 2 (2015): 357-362. https://doi.org/10.3892/mco.2014.480
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