Accurate diagnosis of axillary lymph node metastasis using contrast-enhanced ultrasonography with Sonazoid

Matsuzawa,Fumihiko; Einama,Takahiro; Abe,Hironori; Suzuki,Takashi; Hamaguchi,Jun; Kaga,Terumi; Sato,Mami; Oomura,Masako; Takata,Yumiko; Fujibe,Ayako; Takeda,Chie; Tamura,Etsuya; Taketomi,Akinobu; Kyuno,Kenichi

doi:10.3892/mco.2014.483

March-2015 Volume 3 Issue 2

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March-2015 Volume 3 Issue 2

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Article

Accurate diagnosis of axillary lymph node metastasis using contrast-enhanced ultrasonography with Sonazoid

Authors:
- Fumihiko Matsuzawa
- Takahiro Einama
- Hironori Abe
- Takashi Suzuki
- Jun Hamaguchi
- Terumi Kaga
- Mami Sato
- Masako Oomura
- Yumiko Takata
- Ayako Fujibe
- Chie Takeda
- Etsuya Tamura
- Akinobu Taketomi
- Kenichi Kyuno
View Affiliations / Copyright

Affiliations: Department of Surgery, Hokkaido Social Work Association Obihiro Hospital, Obihiro, Hokkaido 080‑0805, Japan, Department of Clinical Laboratory, Hokkaido Social Work Association Obihiro Hospital, Obihiro, Hokkaido 080‑0805, Japan, Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan
Pages: 299-302
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Published online on: December 31, 2014

https://doi.org/10.3892/mco.2014.483
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Abstract

Axillary lymph node enlargement following sentinel lymph node biopsy (SLNB) is often difficult to accurately diagnose. In keeping with the characteristically tortuous and aberrant pattern of tumor neovasculature, metastatic lymph nodes exhibit peripheral and mixed vascularity, resulting in a microvasculature that is often difficult to visualize. Contrast‑enhanced ultrasonography (CEUS) with Sonazoid, a new generation contrast agent for ultrasonography, allows for the visualization of lymph node microvessels and may enable a more accurate evaluation of lymph node metastasis. This is a case report of axillary lymph node enlargement following SLNB, in which CEUS with Sonazoid resulted in an accurate diagnosis. On the basis of our experience with this case, we have initiated a clinical trial to evaluate the detection of lymph node metastasis through the use of CEUS in breast cancer patients.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Accurate diagnosis of axillary lymph node metastasis using contrast-enhanced ultrasonography with Sonazoid

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