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Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection

  • Authors:
    • Bo Zhang
    • Dan Wang
    • Yunbao Guo
    • Jinlu Yu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, First Hospital of Jilin University, Changchun 130021, P.R. China, Department of Ophthalmology, First Hospital of Jilin University, Changchun 130021, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 501-505
    |
    Published online on: January 22, 2015
       https://doi.org/10.3892/mco.2015.493
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Abstract

The aim of the present study was to identify the major factors correlated with early postoperative seizures in elderly patients who had undergone a meningioma resection, and subsequently, to develop a logistic regression equation for assessing the seizures risk. Fourteen factors possibly correlated with early postoperative seizures in a cohort of 209 elderly patients who had undergone meningioma resection, as analyzed by multifactorial stepwise logistic regression. Phenobarbital sodium (0.1 g, intramuscularly) was administered to all 209 patients 30 min prior to undergoing surgery. All the patients had no previous history of seizures. The correlation of the 14 clinical factors (gender, tumor site, dyskinesia, peritumoral brain edema (PTBE), tumor diameter, pre‑ and postoperative prophylaxes, surgery time, tumor adhesion, circumscription, blood supply, intraoperative transfusion, original site of the tumor and dysphasia) was assessed in association with the risk for post‑operative seizures. Tumor diameter, postoperative prophylactic antiepileptic drug (PPAD) administration, PTBE and tumor site were entered as risk factors into a mathematical regression model. The odds ratio (OR) of the tumor diameter was >1, and PPAD administration showed an OR >1, relative to a non‑prophylactic group. A logistic regression equation was obtained and the sensitivity, specificity and misdiagnosis rates were 91.4, 74.3 and 25.7%, respectively. Tumor diameter, PPAD administration, PTBE and tumor site were closely correlated with early postoperative seizures; PTBE and PPAD administration were risk and protective factors, respectively.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang B, Wang D, Guo Y and Yu J: Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection. Mol Clin Oncol 3: 501-505, 2015.
APA
Zhang, B., Wang, D., Guo, Y., & Yu, J. (2015). Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection. Molecular and Clinical Oncology, 3, 501-505. https://doi.org/10.3892/mco.2015.493
MLA
Zhang, B., Wang, D., Guo, Y., Yu, J."Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection". Molecular and Clinical Oncology 3.3 (2015): 501-505.
Chicago
Zhang, B., Wang, D., Guo, Y., Yu, J."Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection". Molecular and Clinical Oncology 3, no. 3 (2015): 501-505. https://doi.org/10.3892/mco.2015.493
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang B, Wang D, Guo Y and Yu J: Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection. Mol Clin Oncol 3: 501-505, 2015.
APA
Zhang, B., Wang, D., Guo, Y., & Yu, J. (2015). Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection. Molecular and Clinical Oncology, 3, 501-505. https://doi.org/10.3892/mco.2015.493
MLA
Zhang, B., Wang, D., Guo, Y., Yu, J."Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection". Molecular and Clinical Oncology 3.3 (2015): 501-505.
Chicago
Zhang, B., Wang, D., Guo, Y., Yu, J."Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection". Molecular and Clinical Oncology 3, no. 3 (2015): 501-505. https://doi.org/10.3892/mco.2015.493
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