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Article

Prognostic significance of osteopontin expression in non-small-cell lung cancer: A meta-analysis

  • Authors:
    • Xue‑Lin Zou
    • Chun Wang
    • Ke Liu
    • Wen Nie
    • Zhen‑Yu Ding
  • View Affiliations / Copyright

    Affiliations: Division of Thoracic Cancer, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Endocrinology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Occupational Health and Radiological Health, Zigong Center for Disease Control and Prevention, Zigong, Sichuan 643000, P.R. China, School of Clinical Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 633-638
    |
    Published online on: February 26, 2015
       https://doi.org/10.3892/mco.2015.517
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Abstract

Osteopontin (OPN) plays an important role in the progression and metastasis of cancer. However, the role of OPN as a prognostic factor in non‑small‑cell lung cancer (NSCLC) remains controversial. The aim of this study was to investigate the association between OPN expression and prognosis in patients with NSCLC using a meta‑analysis. Based on PubMed, Ovid Medline, Embase, ISI, ScienceDirect and SpringerLink databases, related articles published prior to January, 2013 were collected. A meta‑analysis was conducted to investigate the association of OPN expression with overall survival (OS) and progression‑free survival (PFS) in patients with NSCLC. Hazard ratio (HR) with 95% confidence interval (CI) was used to assess the strength of this association. A total of 6 studies, including 776 patients, were found to be eligible for the meta‑analysis. No heterogeneity was observed in OS or PFS, whereas low OPN expression was found to be correlated with better OS (HR=0.57, 95% CI: 0.46‑0.70) and PFS (HR=0.62, 95% CI: 0.49‑0.77). This meta‑analysis demonstrated an association of OPN with poor prognosis in NSCLC patients. However, prospective studies are required to confirm these findings.
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Copy and paste a formatted citation
Spandidos Publications style
Zou XL, Wang C, Liu K, Nie W and Ding ZY: Prognostic significance of osteopontin expression in non-small-cell lung cancer: A meta-analysis. Mol Clin Oncol 3: 633-638, 2015.
APA
Zou, X., Wang, C., Liu, K., Nie, W., & Ding, Z. (2015). Prognostic significance of osteopontin expression in non-small-cell lung cancer: A meta-analysis. Molecular and Clinical Oncology, 3, 633-638. https://doi.org/10.3892/mco.2015.517
MLA
Zou, X., Wang, C., Liu, K., Nie, W., Ding, Z."Prognostic significance of osteopontin expression in non-small-cell lung cancer: A meta-analysis". Molecular and Clinical Oncology 3.3 (2015): 633-638.
Chicago
Zou, X., Wang, C., Liu, K., Nie, W., Ding, Z."Prognostic significance of osteopontin expression in non-small-cell lung cancer: A meta-analysis". Molecular and Clinical Oncology 3, no. 3 (2015): 633-638. https://doi.org/10.3892/mco.2015.517
Copy and paste a formatted citation
x
Spandidos Publications style
Zou XL, Wang C, Liu K, Nie W and Ding ZY: Prognostic significance of osteopontin expression in non-small-cell lung cancer: A meta-analysis. Mol Clin Oncol 3: 633-638, 2015.
APA
Zou, X., Wang, C., Liu, K., Nie, W., & Ding, Z. (2015). Prognostic significance of osteopontin expression in non-small-cell lung cancer: A meta-analysis. Molecular and Clinical Oncology, 3, 633-638. https://doi.org/10.3892/mco.2015.517
MLA
Zou, X., Wang, C., Liu, K., Nie, W., Ding, Z."Prognostic significance of osteopontin expression in non-small-cell lung cancer: A meta-analysis". Molecular and Clinical Oncology 3.3 (2015): 633-638.
Chicago
Zou, X., Wang, C., Liu, K., Nie, W., Ding, Z."Prognostic significance of osteopontin expression in non-small-cell lung cancer: A meta-analysis". Molecular and Clinical Oncology 3, no. 3 (2015): 633-638. https://doi.org/10.3892/mco.2015.517
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