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Article

Plasma neuron-specific enolase level as a prognostic marker in patients with non-small cell lung cancer receiving gefitinib

  • Authors:
    • Minehiko Inomata
    • Ryuji Hayashi
    • Azusa Yamamoto
    • Kotaro Tokui
    • Chihiro Taka
    • Seisuke Okazawa
    • Kenta Kambara
    • Kensuke Suzuki
    • Tomomi Ichikawa
    • Toru Yamada
    • Toshiro Miwa
    • Tatsuhiko Kashii
    • Shoko Matsui
    • Kazuyuki Tobe
    • Johji Imura
  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Toyama 930‑0194, Japan, Department of Respiratory Medicine, Toyama Prefectural Central Hospital, Toyama, Toyama 930‑8550, Japan, Department of Medical Oncology, Toyama University Hospital, Toyama, Toyama 930‑0194, Japan, Health Administration Center, University of Toyama, Toyama, Toyama 930‑0194, Japan, Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Toyama 930‑0194, Japan
  • Pages: 802-806
    |
    Published online on: May 14, 2015
       https://doi.org/10.3892/mco.2015.568
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Abstract

Determination of the presence of epidermal growth factor receptor (EGFR) gene mutation is useful for predicting the efficacy of gefitinib. However, the survival rate following the initiation of treatment with gefitinib varies among individuals. A retrospective study was conducted to investigate the associations of the pretreatment serum pro‑gastrin‑releasing peptide (pro‑GRP) and plasma neuron‑specific enolase (NSE) levels to the patient survival rate following initiation of treatment with gefitinib in non‑small cell lung cancer (NSCLC) patients receiving gefitinib treatment. Patients with NSCLC harboring EGFR gene mutations who received gefitinib therapy between 2004 and 2012 were included in the study. Data from a total of 41 patients were analyzed. The serum pro‑GRP level was measured in 31 patients and the plasma NSE in 22 patients. The progression‑free survival (PFS) (P=0.013) and overall survival (OS) (P=0.014, log‑rank test) rates decreased as the plasma NSE level increased. Statistical analysis using a Cox proportional hazards regression model adjusted for age, gender, performance status (PS) and disease stage showed that higher NSE levels were associated with shorter PFS (P=0.021) and OS (P=0.0024). By contrast, no association was detected between the serum level of pro‑GRP and survival rate. The results suggest that pretreatment NSE measurement could be clinically useful in patients with NSCLC scheduled to receive gefitinib treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Inomata M, Hayashi R, Yamamoto A, Tokui K, Taka C, Okazawa S, Kambara K, Suzuki K, Ichikawa T, Yamada T, Yamada T, et al: Plasma neuron-specific enolase level as a prognostic marker in patients with non-small cell lung cancer receiving gefitinib. Mol Clin Oncol 3: 802-806, 2015.
APA
Inomata, M., Hayashi, R., Yamamoto, A., Tokui, K., Taka, C., Okazawa, S. ... Imura, J. (2015). Plasma neuron-specific enolase level as a prognostic marker in patients with non-small cell lung cancer receiving gefitinib. Molecular and Clinical Oncology, 3, 802-806. https://doi.org/10.3892/mco.2015.568
MLA
Inomata, M., Hayashi, R., Yamamoto, A., Tokui, K., Taka, C., Okazawa, S., Kambara, K., Suzuki, K., Ichikawa, T., Yamada, T., Miwa, T., Kashii, T., Matsui, S., Tobe, K., Imura, J."Plasma neuron-specific enolase level as a prognostic marker in patients with non-small cell lung cancer receiving gefitinib". Molecular and Clinical Oncology 3.4 (2015): 802-806.
Chicago
Inomata, M., Hayashi, R., Yamamoto, A., Tokui, K., Taka, C., Okazawa, S., Kambara, K., Suzuki, K., Ichikawa, T., Yamada, T., Miwa, T., Kashii, T., Matsui, S., Tobe, K., Imura, J."Plasma neuron-specific enolase level as a prognostic marker in patients with non-small cell lung cancer receiving gefitinib". Molecular and Clinical Oncology 3, no. 4 (2015): 802-806. https://doi.org/10.3892/mco.2015.568
Copy and paste a formatted citation
x
Spandidos Publications style
Inomata M, Hayashi R, Yamamoto A, Tokui K, Taka C, Okazawa S, Kambara K, Suzuki K, Ichikawa T, Yamada T, Yamada T, et al: Plasma neuron-specific enolase level as a prognostic marker in patients with non-small cell lung cancer receiving gefitinib. Mol Clin Oncol 3: 802-806, 2015.
APA
Inomata, M., Hayashi, R., Yamamoto, A., Tokui, K., Taka, C., Okazawa, S. ... Imura, J. (2015). Plasma neuron-specific enolase level as a prognostic marker in patients with non-small cell lung cancer receiving gefitinib. Molecular and Clinical Oncology, 3, 802-806. https://doi.org/10.3892/mco.2015.568
MLA
Inomata, M., Hayashi, R., Yamamoto, A., Tokui, K., Taka, C., Okazawa, S., Kambara, K., Suzuki, K., Ichikawa, T., Yamada, T., Miwa, T., Kashii, T., Matsui, S., Tobe, K., Imura, J."Plasma neuron-specific enolase level as a prognostic marker in patients with non-small cell lung cancer receiving gefitinib". Molecular and Clinical Oncology 3.4 (2015): 802-806.
Chicago
Inomata, M., Hayashi, R., Yamamoto, A., Tokui, K., Taka, C., Okazawa, S., Kambara, K., Suzuki, K., Ichikawa, T., Yamada, T., Miwa, T., Kashii, T., Matsui, S., Tobe, K., Imura, J."Plasma neuron-specific enolase level as a prognostic marker in patients with non-small cell lung cancer receiving gefitinib". Molecular and Clinical Oncology 3, no. 4 (2015): 802-806. https://doi.org/10.3892/mco.2015.568
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