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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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November-2015 Volume 3 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Neuroendocrine differentiation in castration-resistant prostate cancer: A case report

  • Authors:
    • Dimitrios Priftakis
    • Nikolaos Kritikos
    • Stavros Stavrinides
    • Stefanos Kleanthous
    • Nikolaos Baziotis
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, St. Savvas Anticancer‑Oncology Hospital, 11522 Athens, Greece, Department of Gastroenterology, St. Savvas Anticancer‑Oncology Hospital, 11522 Athens, Greece
  • Pages: 1392-1394
    |
    Published online on: September 16, 2015
       https://doi.org/10.3892/mco.2015.645
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Abstract

The most common type of prostate cancer is acinar adenocarcinoma, which is androgen-dependent and, therefore, treated with chemical or surgical castration and androgen receptor inhibition. However, the disease usually progresses to castration‑resistant prostate cancer (CRPC). a neuroendocrine pattern is frequently observed in the cellular composition of CRPC, which is considered to emerge as an effect of androgen deprivation therapy. This is the case report of a 69‑year‑old patient with prostate adenocarcinoma, who, after an initial period of disease control with radiotherapy and antiandrogens, was diagnosed with CRPC with high levels of prostate‑specific antigen (PSA), unresponsive to androgen inhibition, with accompanying lung and osseous metastases. Bronchial biopsy of the lung metastasis revealed infiltration by non‑small‑cell adenocarcinoma of prostatic origin with neuroendocrine characteristics. On somatostatin receptor scintigraphy with 99mTc‑octreotide, there was high uptake by almost all known lung and osseous metastases. The patient was subsequently treated with a combination of docetaxel and octreotide, and a partial response was observed 6 months later, with reduction of the PSA level and the size of the lung metastasis. The aim of the present study was to provide a clinical example of the previously demonstrated, in vitro and in vivo, synergistic antitumor activities of docetaxel and octreotide in cases of CRPC selected by means of histological confirmation of their neuroendocrine nature and somatostatin receptor scintigraphy.
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Copy and paste a formatted citation
Spandidos Publications style
Priftakis D, Kritikos N, Stavrinides S, Kleanthous S and Baziotis N: Neuroendocrine differentiation in castration-resistant prostate cancer: A case report. Mol Clin Oncol 3: 1392-1394, 2015.
APA
Priftakis, D., Kritikos, N., Stavrinides, S., Kleanthous, S., & Baziotis, N. (2015). Neuroendocrine differentiation in castration-resistant prostate cancer: A case report. Molecular and Clinical Oncology, 3, 1392-1394. https://doi.org/10.3892/mco.2015.645
MLA
Priftakis, D., Kritikos, N., Stavrinides, S., Kleanthous, S., Baziotis, N."Neuroendocrine differentiation in castration-resistant prostate cancer: A case report". Molecular and Clinical Oncology 3.6 (2015): 1392-1394.
Chicago
Priftakis, D., Kritikos, N., Stavrinides, S., Kleanthous, S., Baziotis, N."Neuroendocrine differentiation in castration-resistant prostate cancer: A case report". Molecular and Clinical Oncology 3, no. 6 (2015): 1392-1394. https://doi.org/10.3892/mco.2015.645
Copy and paste a formatted citation
x
Spandidos Publications style
Priftakis D, Kritikos N, Stavrinides S, Kleanthous S and Baziotis N: Neuroendocrine differentiation in castration-resistant prostate cancer: A case report. Mol Clin Oncol 3: 1392-1394, 2015.
APA
Priftakis, D., Kritikos, N., Stavrinides, S., Kleanthous, S., & Baziotis, N. (2015). Neuroendocrine differentiation in castration-resistant prostate cancer: A case report. Molecular and Clinical Oncology, 3, 1392-1394. https://doi.org/10.3892/mco.2015.645
MLA
Priftakis, D., Kritikos, N., Stavrinides, S., Kleanthous, S., Baziotis, N."Neuroendocrine differentiation in castration-resistant prostate cancer: A case report". Molecular and Clinical Oncology 3.6 (2015): 1392-1394.
Chicago
Priftakis, D., Kritikos, N., Stavrinides, S., Kleanthous, S., Baziotis, N."Neuroendocrine differentiation in castration-resistant prostate cancer: A case report". Molecular and Clinical Oncology 3, no. 6 (2015): 1392-1394. https://doi.org/10.3892/mco.2015.645
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