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Article

Unplanned discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia

  • Authors:
    • Yutaka Tsutsumi
    • Shinichi Ito
    • Hiroyuki Ohigashi
    • Souichi Shiratori
    • Takanori Teshima
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Hakodate Municipal Hospital, Hakodate, Hokkaido 041-8680, Japan, Department of Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan
  • Pages: 89-92
    |
    Published online on: October 15, 2015
       https://doi.org/10.3892/mco.2015.653
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Abstract

This study was conducted to investigate the outcomes of patients with chronic myeloid leukemia (CML) who discontinued tyrosine kinase inhibitor (TKI) treatment. A single‑center retrospective analysis was performed, including 46 chronic-phase (CP) CML patients who achieved complete molecular response (CMR) with TKIs. TKI treatment was discontinued in 13 patients based on their requests. The BCR-ABL transcript levels were monitored in the peripheral blood by quantitative polymerase chain reaction analysis following treatment discontinuation. of the 13 patients who discontinued TKI treatment, 7 remained in CMR, with a median follow-up of 26 months (range, 10-60 months). The remaining 6 patients lost CMR following TKI discontinuation; 2 of these patients achieved a second CMR following re-administration of TKIs, 2 patients spontaneously achieved CMR and 2 remained in complete hematological response (CHR) without TKI treatment with a median follow-up of 29.5 months (range, 10-52 months). In conclusion, the survival of patients who lost CMR following TKI discontinuation may not be affected, even without re-administration of TKIs. vigilant observation is recommended for such patients. The limitations of this study included the small patient sample, retrospective design and patient heterogeneity. Therefore, the results must be interpreted with caution.
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Copy and paste a formatted citation
Spandidos Publications style
Tsutsumi Y, Ito S, Ohigashi H, Shiratori S and Teshima T: Unplanned discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia. Mol Clin Oncol 4: 89-92, 2016.
APA
Tsutsumi, Y., Ito, S., Ohigashi, H., Shiratori, S., & Teshima, T. (2016). Unplanned discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia. Molecular and Clinical Oncology, 4, 89-92. https://doi.org/10.3892/mco.2015.653
MLA
Tsutsumi, Y., Ito, S., Ohigashi, H., Shiratori, S., Teshima, T."Unplanned discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia". Molecular and Clinical Oncology 4.1 (2016): 89-92.
Chicago
Tsutsumi, Y., Ito, S., Ohigashi, H., Shiratori, S., Teshima, T."Unplanned discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia". Molecular and Clinical Oncology 4, no. 1 (2016): 89-92. https://doi.org/10.3892/mco.2015.653
Copy and paste a formatted citation
x
Spandidos Publications style
Tsutsumi Y, Ito S, Ohigashi H, Shiratori S and Teshima T: Unplanned discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia. Mol Clin Oncol 4: 89-92, 2016.
APA
Tsutsumi, Y., Ito, S., Ohigashi, H., Shiratori, S., & Teshima, T. (2016). Unplanned discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia. Molecular and Clinical Oncology, 4, 89-92. https://doi.org/10.3892/mco.2015.653
MLA
Tsutsumi, Y., Ito, S., Ohigashi, H., Shiratori, S., Teshima, T."Unplanned discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia". Molecular and Clinical Oncology 4.1 (2016): 89-92.
Chicago
Tsutsumi, Y., Ito, S., Ohigashi, H., Shiratori, S., Teshima, T."Unplanned discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia". Molecular and Clinical Oncology 4, no. 1 (2016): 89-92. https://doi.org/10.3892/mco.2015.653
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