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Article

Novel agent induction therapy alone or followed by autologous stem cell transplantation in younger patients with multiple myeloma: A single‑center retrospective study of 114 cases

  • Authors:
    • Yan Wang
    • Pengpeng Xu
    • Yubao Chen
    • Qingye Fan
    • Junmin Li
    • Weili Zhao
    • Jianqing Mi
    • Hua Yan
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Ruijin Hospital, Shanghai Jiao‑Tong University School of Medicine, Shanghai 200025, P.R. China
  • Pages: 107-113
    |
    Published online on: October 16, 2015
       https://doi.org/10.3892/mco.2015.658
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Abstract

To define the role of autologous stem cell transplantation (ASCT) in newly diagnosed multiple myeloma (MM) in the era of novel agents, we analyzed follow‑up data of patients treated by these agents alone or followed by ASCT. From January, 2008 to December, 2012, 136 patients with de novo MM, aged <65 years, completed bortezomib‑ or thalidomide‑based induction therapy and 114 patients achieved at least a partial response (PR). A total of 42 patients underwent ASCT. After a median follow‑up of 39 months (range, 5‑74 months), the median progression‑free survival (PFS) was 23 months in the non‑ASCT group vs. 42 months in the ASCT group (P=0.001), and the 5‑year overall survival (OS) rate was 58.9 vs. 81.2%, respectively (P=0.03). The multivariate analysis revealed that complete response (CR) and maintenance therapy (MT) were independent factors of improved OS in both groups. Moreover, a subgroup analysis was performed according to the response status to evaluate the role of ASCT and MT. In the CR subgroup, neither ASCT nor MT exerted a significant effect on PFS or OS. In the very good PR subgroup, ASCT after MT (ASCT̸MT) significantly improved PFS, but not OS. In patients exhibiting PR, ASCT̸MT significantly prolonged PFS and OS. Therefore, ASCT in the era of novel agents maintains an important role in younger MM patients, particularly those achieving a PR after induction therapy. Furthermore, MT is a key factor associated with long‑term survival in all MM patients.
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1 

Collaborative Group: Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: An overview of 6,633 patients from 27 randomized trials. Myeloma Trialists' Collaborative Group. J Clin Oncol. 16:3832–3842. 1998.PubMed/NCBI

2 

Harousseau JL and Attal M: The role of autologous hematopoietic stem cell transplantation in multiple myeloma. Semin Hematol. 34(1 Suppl 1): 61–66. 1997.PubMed/NCBI

3 

Blade J, Rosinol L, Cibera MT, Rovira M and Carreras E: Hematopoietic stem cell transplantation for multiple myeloma beyond 2010. Blood. 115:3655–3663. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Van de Velde HJ, Liu X, Chen G, Cakana A, Deraedt W and Bayssas M: Complete response correlates with long-term survival and progression-free survival in high-dose therapy in multiple myeloma. Haematologica. 92:1399–1406. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Kumar S, Flinn I, Richardson PG, Hari P, Callander N, Noga SJ, Stewart AK, Turturro F, Rifkin R, Wolf J, et al: Randomized, multicenter, phase 2 study (EVOLUTION) of combinations of bortezomib, dexamethasone, cyclophosphamide and lenalidomide in previously untreated multiple myeloma. Blood. 119:4375–4382. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Chanan-Kahn AA and Giralt S: Importance of achieving complete response in multiple myeloma and the impact of novel agents. J Clin Oncol. 28:2612–2624. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Boccadoro M, Cavallo F, Nagler A, Ben Yehuda D, Omedè P, Cavalli M, Levi A, Crippa C, Siniscalchi A, Brasca P, et al: Melphalan/prednisone/lenalidomide (MPR) versus high-dose melphalan and autologous transplantation (MEL200) in newly diagnosed multiple myeloma (MM) patients: a phase III trial. J Clin Oncol. 29(Supp 1): 8020–8027. 2011.

8 

Gay F, Hajek R, Diramondo F, et al: Cyclophosphamide lenalidomide-dexamethasone vs. autologous transplant in newly diagnosed myeloma: a phase 3 trial. Clin Lymphoma Myeloma Leuk. 13(Suppl 1): S402013.

9 

Fermand JP, Katsahian S, Divine M, et al: High-dose therapy and autologous blood stem-cell transplantation compared with conventional treatment in myeloma patients aged 55 to 65 years: long-term results of a randomized control trial from the Group Myelome-Autogreffe. J Clin Oncol. 23:9227–9233. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Hahn T, Wingard JR, Anderson KC, et al: The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of multiple myeloma: an evidence-based review. Biol Blood Marrow Transplant. 9:4–37. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Moreau P, Avet-Loiseau H, Facon T, Attal M, Tiab M, Hulin C, Doyen C, Garderet L, Randriamalala E, Araujo C, et al: Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment before autologous stem cell transplantation in newly diagnosed multiple myeloma. Blood. 118:5752–5758. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Jakubowiak AJ, Griffith KA, Reece DE, Hofmeister CC, Lonial S, Zimmerman TM, Campagnaro EL, Schlossman RL, Laubach JP, Raje NS, et al: Lenalidomide, bortezomib, pegylated liposomal doxorubicin and dexamethasone in newly diagnosed multiple myeloma: a phase 1/2 Multiple Myeloma Research Consortium trial. Blood. 118:535–543. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Kenneth C Anderson, Melissa Alsina, William Bensinger, et al: Multiple Myeloma. Version 1.2013 J Natl Compr Canc Netw. 11:11–17. 2013.

14 

Durie BG, Harousseau JL, Miguel JS, et al: International uniform response criteria for multiple myeloma. Leukemia. 20:1467–1473. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Haroussear JL, Attal M and Avet-Loiseau H: The role of complete response in multiple myeloma. Blood. 114:3139–3146. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Attal M, Harousseau JL, Stoppa AM, Sotto JJ, Fuzibet JG, Rossi JF, Casassus P, Maisonneuve H, Facon T, Ifrah N, et al: A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Français du Myélome. N Engl J Med. 335:91–97. 1996. View Article : Google Scholar : PubMed/NCBI

17 

Child JA, Morgan GJ, Davies FE, Owen RG, Bell SE, Hawkins K, Brown J, Drayson MT and Selby PJ: Medical Research Council Adult Leukaemia Working Party: High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma. N Engl J Med. 348:1875–1883. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Harousseau JL, Palumbo A, Richardson PG, Schlag R, Dimopoulos MA, Shpilberg O, Kropff M, Kentos A, Cavo M, Golenkov A, et al: Superior outcomes associated with complete response in newly diagnosed multiple myeloma patients treated with nonintensive therapy: analysis of the phase 3 VISTA study of bortezomib plus melphalan-prednisone versus melphalan-prednisone. Blood. 116:3743–3750. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Reeder CB, Reece DE, Kukreti V, Chen C, Trudel S, Hentz J, Noble B, Pirooz NA, Spong JE, Piza JG, et al: Cyclophosphamide, bortezomib and dexamethasone induction for newly diagnosed multiple myeloma: high response rates in a phase II clinical trial. Leukemia. 23:1337–1341. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Kumar L, Iqbal N, Mookerjee A, Verma RK, Sharma OD, Batra A, Pramanik R and Gupta R: Complete response after autologous stem cell transplant in multiple myeloma. Cancer Med. 3:939–946. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Spencer A, Prince HM, Roberts AW, Prosser IW, Bradstock KF, Coyle L, Gill DS, Horvath N, Reynolds J and Kennedy N: Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedure. J Clin Oncol. 27:1788–1793. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Attal M, Harousseau JL, Leyvraz S, Doyen C, Hulin C, Benboubker L, Agha Yakoub I, Bourhis JH, Garderet L, Pegourie B, et al: Inter-Groupe Francophone du Myélome (IFM).: Maintenance therapy with thalidomide improves survival in patients with multiple myeloma. Blood. 108:3289–3294. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Barlogie B, Tricot G, Anaissie E, Shaughnessy J, Rasmussen E, van Rhee F, Fassas A, Zangari M, Hollmig K, Pineda-Roman M, et al: Thalidomide and hematopoietic cell transplantation for multiple myeloma. N Engl J Med. 354:1021–1030. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Attal M and Roussel M: Maintenance therapy for myeloma. How much, how long and at what cost? Am Soc Clin Oncol Educ Book. 32:515–522. 2012.

25 

Kapoor P, Kumar SK, Dispenzieri A, et al: Importance of achieving stringent complete response after autologous stem-cell transplantation in multiple myeloma. J Clin Oncol. 31:4529–4535. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Bergantim R, Trigo F and Guimaraes JE: Impact of tandem autologous stem cell transplantation and response to transplant in the outcome of multiple myeloma. Exp Hematol Oncol. 1:35–38. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Martinez-Lopez J, Blade J, Mateos MV, et al: Long-term prognostic significance of response in multiple myeloma after stem cell transplantation. Blood. 118:529–534. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Xu P, Chen Y, Fan Q, Li J, Zhao W, Mi J and Yan H: Novel agent induction therapy alone or followed by autologous stem cell transplantation in younger patients with multiple myeloma: A single‑center retrospective study of 114 cases. Mol Clin Oncol 4: 107-113, 2016.
APA
Wang, Y., Xu, P., Chen, Y., Fan, Q., Li, J., Zhao, W. ... Yan, H. (2016). Novel agent induction therapy alone or followed by autologous stem cell transplantation in younger patients with multiple myeloma: A single‑center retrospective study of 114 cases. Molecular and Clinical Oncology, 4, 107-113. https://doi.org/10.3892/mco.2015.658
MLA
Wang, Y., Xu, P., Chen, Y., Fan, Q., Li, J., Zhao, W., Mi, J., Yan, H."Novel agent induction therapy alone or followed by autologous stem cell transplantation in younger patients with multiple myeloma: A single‑center retrospective study of 114 cases". Molecular and Clinical Oncology 4.1 (2016): 107-113.
Chicago
Wang, Y., Xu, P., Chen, Y., Fan, Q., Li, J., Zhao, W., Mi, J., Yan, H."Novel agent induction therapy alone or followed by autologous stem cell transplantation in younger patients with multiple myeloma: A single‑center retrospective study of 114 cases". Molecular and Clinical Oncology 4, no. 1 (2016): 107-113. https://doi.org/10.3892/mco.2015.658
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Xu P, Chen Y, Fan Q, Li J, Zhao W, Mi J and Yan H: Novel agent induction therapy alone or followed by autologous stem cell transplantation in younger patients with multiple myeloma: A single‑center retrospective study of 114 cases. Mol Clin Oncol 4: 107-113, 2016.
APA
Wang, Y., Xu, P., Chen, Y., Fan, Q., Li, J., Zhao, W. ... Yan, H. (2016). Novel agent induction therapy alone or followed by autologous stem cell transplantation in younger patients with multiple myeloma: A single‑center retrospective study of 114 cases. Molecular and Clinical Oncology, 4, 107-113. https://doi.org/10.3892/mco.2015.658
MLA
Wang, Y., Xu, P., Chen, Y., Fan, Q., Li, J., Zhao, W., Mi, J., Yan, H."Novel agent induction therapy alone or followed by autologous stem cell transplantation in younger patients with multiple myeloma: A single‑center retrospective study of 114 cases". Molecular and Clinical Oncology 4.1 (2016): 107-113.
Chicago
Wang, Y., Xu, P., Chen, Y., Fan, Q., Li, J., Zhao, W., Mi, J., Yan, H."Novel agent induction therapy alone or followed by autologous stem cell transplantation in younger patients with multiple myeloma: A single‑center retrospective study of 114 cases". Molecular and Clinical Oncology 4, no. 1 (2016): 107-113. https://doi.org/10.3892/mco.2015.658
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