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Molecular and Clinical Oncology
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February-2016 Volume 4 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Tyrosine kinase inhibitors improve parenchymal findings of liver cirrhosis in a patient exhibiting concomitant hepatocellular carcinoma and renal cell cancer

  • Authors:
    • Tulay Kus
    • Gokmen Aktas
    • Alper Sevinc
    • Cemil Oktay
    • Mehmet Emin Kalender
    • Celaletdin Camci
  • View Affiliations / Copyright

    Affiliations: Division of Medical Oncology, Department of Internal Medicine, Gaziantep Oncology Hospital, School of Medicine, Gaziantep University, Gaziantep TR‑27310, Turkey, Department of Radiology, School of Medicine, Akdeniz University, Antalya TR‑07100, Turkey
  • Pages: 290-292
    |
    Published online on: November 13, 2015
       https://doi.org/10.3892/mco.2015.677
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Abstract

Hepatocellular carcinoma (HCC) and renal cell cancer (RCC) are malignancies, which are chemotherapy resistant and fatal at the advanced stages. Previously developed tyrosine kinase inhibitors are used in the treatment of advanced stage disease. In the present case study, a patient using sunitinib for stage IV RCC presented with HCC following 2 years of treatment. A patient who exhibited Child‑Pugh class C cirrhosis initially, exhibited a marked improvement of hepatocellular parenchyma findings following treatment with sunitinib. Sunitinib is suggested to have preventive effects on the pathogenesis of liver fibrosis and cirrhosis in vitro, via an anti‑vascular endothelial growth factor and anti‑platelet‑derived growth factor mechanism. However, no clinical supportive study has been performed until now. Improvement of liver functions may be explained in this manner. Therefore, investigations are required with different doses of sunitinib and other tyrosine kinase inhibitors in order to evaluate the efficacy on treatment of cirrhosis progression.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Ikeda K, Saitoh S, Koida I, Arase Y, Tsubota A, Chayama K, Kumada H and Kawanishi M: A multivariate analysis of risk factors for hepatocellular carcinogenesis: A prospective observation of 795 patients with viral and alcoholic cirrhosis. Hepatology. 18:47–53. 1993. View Article : Google Scholar : PubMed/NCBI

3 

Zhang W, Zhao G, Wei K, Zhang Q, Ma W, Song T, Wu Q, Zhang T, Kong D and Li Q: Adjuvant sorafenib reduced mortality and prolonged overall survival and post-recurrence survival in hepatocellular carcinoma patients after curative resection: A single-center experience. Biosci Trends. 8:333–338. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Wang SN, Chuang SC and Lee KT: Efficacy of sorafenib as adjuvant therapy to prevent early recurrence of hepatocellular carcinoma after curative surgery: A pilot study. Hepatol Res. 44:523–531. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Chung YH, Han G, Yoon JH, Yang J, Wang J, Shao GL, Kim BI, Lee TY and Chao Y: Interim analysis of START: Study in Asia of the combination of TACE (transcatheter arterial chemoembolization) with sorafenib in patients with hepatocellular carcinoma trial. Int J Cancer. 132:2448–2458. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Culp SH, Tannir NM, Abel EJ, Margulis V, Tamboli P, Matin SF and Wood CG: Can we better select patients with metastatic renal cell carcinoma for cytoreductive nephrectomy? Cancer. 116:3378–3388. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Albiges L, Kube U, Eymard JC, Schmidinger M, Bamias A, Kelkouli N, Mraz B, Florini S, Guderian G, Cattaneo A, et al: Everolimus for patients with metastatic renal cell carcinoma refractory to anti-VEGF therapy: Results of a pooled analysis of non-interventional studies. Eur J Cancer. 51:2368–2374. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Oudard S and Vano Y: The role of rechallenge with targeted therapies in metastatic renal-cell carcinoma. Curr Opin Urol. 25:402–410. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Eichelberg C, Vervenne WL, De Santis M, von Weikersthal Fischer L, Goebell PJ, Lerchenmüller C, Zimmermann U, Bos MM, Freier W, Schirrmacher-Memmel S, et al: SWITCH: A Randomised, Sequential, Open-label Study to Evaluate the Efficacy and Safety of Sorafenib-sunitinib Versus Sunitinib-sorafenib in the Treatment of Metastatic Renal Cell Cancer. Eur Urol. 68:837–847. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM and Lynch M: Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther. 7:3129–3140. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, et al: Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 359:378–390. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, Luo R, Feng J, Ye S, Yang TS, et al: Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 10:25–34. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Barone C, Basso M, Biolato M, Pompili M, Rufini V, Miele L, Basso M, De Gaetano AM, Castaldi P, Iaculli A, et al: A phase II study of sunitinib in advanced hepatocellular carcinoma. Dig Liver Dis. 45:692–698. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Cheng AL, Kang YK, Lin DY, Park JW, Kudo M, Qin S, Chung HC, Song X, Xu J, Poggi G, et al: Sunitinib versus sorafenib in advanced hepatocellular cancer: Results of a randomized phase III trial. J Clin Oncol. 31:4067–4075. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Majumder S, Piguet AC, Dufour JF and Chatterjee S: Study of the cellular mechanism of sunitinib mediated inactivation of activated hepatic stellate cells and its implications in angiogenesis. Eur J Pharmacol. 705:86–95. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kus T, Aktas G, Sevinc A, Oktay C, Kalender ME and Camci C: Tyrosine kinase inhibitors improve parenchymal findings of liver cirrhosis in a patient exhibiting concomitant hepatocellular carcinoma and renal cell cancer. Mol Clin Oncol 4: 290-292, 2016.
APA
Kus, T., Aktas, G., Sevinc, A., Oktay, C., Kalender, M.E., & Camci, C. (2016). Tyrosine kinase inhibitors improve parenchymal findings of liver cirrhosis in a patient exhibiting concomitant hepatocellular carcinoma and renal cell cancer. Molecular and Clinical Oncology, 4, 290-292. https://doi.org/10.3892/mco.2015.677
MLA
Kus, T., Aktas, G., Sevinc, A., Oktay, C., Kalender, M. E., Camci, C."Tyrosine kinase inhibitors improve parenchymal findings of liver cirrhosis in a patient exhibiting concomitant hepatocellular carcinoma and renal cell cancer". Molecular and Clinical Oncology 4.2 (2016): 290-292.
Chicago
Kus, T., Aktas, G., Sevinc, A., Oktay, C., Kalender, M. E., Camci, C."Tyrosine kinase inhibitors improve parenchymal findings of liver cirrhosis in a patient exhibiting concomitant hepatocellular carcinoma and renal cell cancer". Molecular and Clinical Oncology 4, no. 2 (2016): 290-292. https://doi.org/10.3892/mco.2015.677
Copy and paste a formatted citation
x
Spandidos Publications style
Kus T, Aktas G, Sevinc A, Oktay C, Kalender ME and Camci C: Tyrosine kinase inhibitors improve parenchymal findings of liver cirrhosis in a patient exhibiting concomitant hepatocellular carcinoma and renal cell cancer. Mol Clin Oncol 4: 290-292, 2016.
APA
Kus, T., Aktas, G., Sevinc, A., Oktay, C., Kalender, M.E., & Camci, C. (2016). Tyrosine kinase inhibitors improve parenchymal findings of liver cirrhosis in a patient exhibiting concomitant hepatocellular carcinoma and renal cell cancer. Molecular and Clinical Oncology, 4, 290-292. https://doi.org/10.3892/mco.2015.677
MLA
Kus, T., Aktas, G., Sevinc, A., Oktay, C., Kalender, M. E., Camci, C."Tyrosine kinase inhibitors improve parenchymal findings of liver cirrhosis in a patient exhibiting concomitant hepatocellular carcinoma and renal cell cancer". Molecular and Clinical Oncology 4.2 (2016): 290-292.
Chicago
Kus, T., Aktas, G., Sevinc, A., Oktay, C., Kalender, M. E., Camci, C."Tyrosine kinase inhibitors improve parenchymal findings of liver cirrhosis in a patient exhibiting concomitant hepatocellular carcinoma and renal cell cancer". Molecular and Clinical Oncology 4, no. 2 (2016): 290-292. https://doi.org/10.3892/mco.2015.677
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