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Article

Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer

  • Authors:
    • Junxiu Yu
    • Shuguang Zhang
    • Bingbo Zhao
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    Affiliations: Department of Gastrointestinal Surgery, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, P.R. China, Laboratory Department, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, P.R. China
  • Pages: 441-449
    |
    Published online on: December 15, 2015
       https://doi.org/10.3892/mco.2015.712
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Abstract

The sensitivity of three biomarkers, carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9 and CA72-4, in combination has been identified to be greater than that of any of the biomarkers considered in isolation in cases of gastric cancer (GC). However, the fundamental cause underlying this phenomenon remains to be fully elucidated. In the present study, the differences and correlation of these three biomarkers were investigated in patients with GC in order to determine how the three biomarkers in combination work more effectively compared with any of the biomarkers considered alone. The serum levels of CEA, CA19‑9 and CA72‑4 of 216 patients with gastric adenocarcinoma were analyzed on admission to hospital. The differences in positive rates and the serum levels of CEA, CA19‑9 and CA72‑4 were analyzed using the χ2 test and the non‑parametric Wilcoxon two‑sample test. Phi (f) correlation analysis was used to study the correlation among the expression (positive or not) levels of CEA, CA19‑9 and CA72‑4. The correlation among the serum levels of biomarkers was analyzed using Spearman's test. The results demonstrated that the combined positive rate of CEA, CA19‑9 and CA72‑4 was significantly higher compared with the individual CEA, CA19‑9 and CA72‑4 positive rates (44.91% vs. 22.69, 18.98 and 22.69%, respectively; all P<0.05). The positive rate of CA19‑9 and CA72‑4 in the extent of the primary tumor/involvement of regional lymph node/distant metastases (TNM)‑III/IV stage subgroup was higher compared with that in the TNM‑I/II subgroup (χ2=5.902, P=0.015; χ2=8.009, P=0.005), although not the positive rate of CEA (χ2=0.302, P=0.583). A significant correlation was identified between the expression level of CEA and CA72‑4 (f correlation coefficient=0.182; P=0.008) and between that of CA19‑9 and CA72‑4 (f correlation coefficient=0.189; P=0.006), although not between that of CEA and CA19‑9 (f correlation coefficient=0.048; P=0.482) in the total number of patients with GC. A significant correlation was also identified between the serum levels of CEA and CA19‑9, of CEA and CA72‑4 and of CA19‑9 and CA72‑4 (Spearman's correlation coefficient=0.231, ‑0.271 and 0.167; P=0.001, P<0.0001 and P=0.014, respectively). The present study indicated that there was only a weak correlation between the positive rate of CEA and CA72‑4 and between that of CA19‑9 and CA72‑4, and no correlation was identified between the positive rate of CEA and CA19‑9, even if a correlation was identified between the serum levels of the biomarkers. The present study suggested that the evidence that the sensitivity of the three biomarkers in combination is greater than that of any of the biomarkers taken in isolation is due to less co-presentation of CEA, CA19-9 and CA72-4 in patients with GC.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Park HJ, Ahn JY, Jung HY, Lim H, Lee JH, Choi KS, do Kim H, Choi KD, Song HJ, Lee GH and Kim JH: Clinical characteristics and outcomes for gastric cancer patients aged 18-30 years. Gastric Cancer. 17:649–660. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Nam DH, Lee YK, Park JC, Lee H, Shin SK, Lee SK, Lee YC, Cheong JH, Hyung WJ, Noh SH and Kim CB: Prognostic value of early postoperative tumor marker response in gastric cancer. Ann Surg Oncol. 20:3905–3911. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Mohri Y, Tanaka K, Ohi M, Saigusa S, Yasuda H, Toiyama Y, Araki T, Inoue Y and Kusunoki M: Identification of prognostic factors and surgical indications for metastatic gastric cancer. BMC Cancer. 14:4092014. View Article : Google Scholar : PubMed/NCBI

5 

Kwon OK, Yu W and Chung H: Prognostic value of postoperative CA19-9 normalization in patients with advanced gastric cancer. Hepatogastroenterology. 60:240–243. 2013.PubMed/NCBI

6 

Kim DH, Oh SJ, Oh CA, Choi MG, Noh JH, Sohn TS, Bae JM and Kim S: The relationships between perioperative CEA, CA 19-9, and CA 72-4 and recurrence in gastric cancer patients after curative radical gastrectomy. J Surg Oncol. 104:585–591. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Jo JC, Ryu MH, Koo DH, Ryoo BY, Kim HJ, Kim TW, Choi KD, Lee GH, Jung HY, Yook JH, et al: Serum CA 19-9 as a prognostic factor in patients with metastatic gastric cancer. Asia Pac J Clin Oncol. 9:324–330. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Choi AR, Park JC, Kim JH, Shin SK, Lee SK, Lee YC and Chung JB: High level of preoperative carbohydrate antigen 19-9 is a poor survival predictor in gastric cancer. World J Gastroenterol. 19:5302–5308. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Shimada H, Noie T, Ohashi M, Oba K and Takahashi Y: Clinical significance of serum tumor markers for gastric cancer, A systematic review of literature by the task force of the Japanese gastric cancer association. Gastric Cancer. 17:26–33. 2014. View Article : Google Scholar : PubMed/NCBI

10 

He CZ, Zhang KH, Li Q, Liu XH, Hong Y and Lv NH: Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer. BMC Gastroenterol. 13:872013. View Article : Google Scholar : PubMed/NCBI

11 

Lee JC, Lee SY, Kim CY and Yang DH: Clinical utility of tumor marker cutoff ratio and a combination scoring system of preoperative carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 72-4 levels in gastric cancer. J Korean Surg Soc. 85:283–289. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Li F, Li S, Wei L, Liang X, Zhang H and Liu J: The correlation between pre-operative serum tumor markers and lymph node metastasis in gastric cancer patients undergoing curative treatment. Biomarkers. 18:632–637. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Yang AP, Liu J, Lei HY, Zhang QW, Zhao L and Yang GH: CA72-4 combined with CEA, CA125 and CAl9-9 improves the sensitivity for the early diagnosis of gastric cancer. Clin Chim Acta. 437:183–186. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Bagaria B, Sood S, Sharma R and Lalwani S: Comparative study of CEA and CA19-9 in esophageal, gastric and colon cancers individually and in combination (ROC curve analysis). Cancer Biol Med. 10:148–157. 2013.PubMed/NCBI

15 

Ychou M, Duffour J, Kramar A, Gourgou S and Grenier J: Clinical significance and prognostic value of CA72-4 compared with CEA and CA19-9 in patients with gastric cancer. Dis Markers. 16:105–110. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Japanese Gastric Cancer Association: Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 14:101–112. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL and Trotti A: AJCC Cancer Staging Handbook. New York: Springer. 2010.

18 

Gold P and Freedman SO: Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med. 121:439–462. 1965. View Article : Google Scholar : PubMed/NCBI

19 

Koprowski H, Steplewski Z, Mitchell K, Herlyn M, Herlyn D and Fuhrer P: Colorectal carcinoma antigens detected by hybridoma antibodies. Somatic Cell Genet. 5:957–971. 1979. View Article : Google Scholar : PubMed/NCBI

20 

Colcher D, Hand PH, Nuti M and Schlom J: A spectrum of monoclonal antibodies reactive with human mammary tumor cells. Proc Natl Acad Sci USA. 78:3199–3203. 1981. View Article : Google Scholar : PubMed/NCBI

21 

Huang ZB, Zhou X, Xu J, Du YP, Zhu W, Wang J, Shu YQ and Liu P: Prognostic value of preoperative serum tumor markers in gastric cancer. World J Clin Oncol. 5:170–176. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Mittal A, Gupta SP, Jha DK, Sathian B and Poudel B: Impact of various tumor markers in prognosis of gastric cancer. Histopathology. Asian Pac J Cancer Prev. 14:1965–1967. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Cidón EU and Bustamante R: Gastric cancer: Tumor markers as predictive factors for preoperative staging. J Gastrointest Cancer. 42:127–130. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Liu X, Cai H and Wang Y: Prognostic significance of tumour markers in Chinese patients with gastric cancer. ANZ J Surg. 84:448–453. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Ucar E, Semerci E, Ustun H, Yetim T, Huzmeli C and Gullu M: Prognostic value of preoperative CEA, CA 19-9, CA 72-4, and AFP levels in gastric cancer. Adv Ther. 25:1075–1084. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Yajima H, Omura N, Matai K, Mitsumori N, Yoshida K and Yanaga K: Clinicopathological features of CA19-9-producing gastric cancer. Hepatogastroenterology. 61:221–225. 2014.PubMed/NCBI

27 

Tian SB, Yu JC, Kang WM, Ma ZQ, Ye X, Cao ZJ and Yan C: Combined detection of CEA, CA 19-9, CA 242 and CA 50 in the diagnosis and prognosis of resectable gastric cancer. Asian Pac J Cancer Prev. 15:6295–6300. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Sisik A, Kaya M, Bas G, Basak F and Alimoglu O: CEA and CA 19-9 are still valuable markers for the prognosis of colorectal and gastric cancer patients. Asian Pac J Cancer Prev. 14:4289–4294. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Han ES, Lee HH, Lee JS, Song KY, Park CH and Jeon HM: At which stage of gastric cancer progression do levels of carcinoembryonic antigen and carbohydrate antigen 19-9 increase? Application in advanced gastric cancer treatment. J Gastric Cancer. 14:123–128. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Chen XZ, Zhang WK, Yang K, Wang LL, Liu J, Wang L, Hu JK, Zhang B, Chen ZX, Chen JP, et al: Correlation between serum CA724 and gastric cancer: Multiple analyses based on Chinese population. Mol Biol Rep. 39:9031–9039. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Emoto S, Ishigami H, Yamashita H, Yamaguchi H, Kaisaki S and Kitayama J: Clinical significance of CA125 and CA72-4 in gastric cancer with peritoneal dissemination. Gastric Cancer. 15:154–161. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yu J, Zhang S and Zhao B: Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer. Mol Clin Oncol 4: 441-449, 2016.
APA
Yu, J., Zhang, S., & Zhao, B. (2016). Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer. Molecular and Clinical Oncology, 4, 441-449. https://doi.org/10.3892/mco.2015.712
MLA
Yu, J., Zhang, S., Zhao, B."Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer". Molecular and Clinical Oncology 4.3 (2016): 441-449.
Chicago
Yu, J., Zhang, S., Zhao, B."Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer". Molecular and Clinical Oncology 4, no. 3 (2016): 441-449. https://doi.org/10.3892/mco.2015.712
Copy and paste a formatted citation
x
Spandidos Publications style
Yu J, Zhang S and Zhao B: Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer. Mol Clin Oncol 4: 441-449, 2016.
APA
Yu, J., Zhang, S., & Zhao, B. (2016). Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer. Molecular and Clinical Oncology, 4, 441-449. https://doi.org/10.3892/mco.2015.712
MLA
Yu, J., Zhang, S., Zhao, B."Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer". Molecular and Clinical Oncology 4.3 (2016): 441-449.
Chicago
Yu, J., Zhang, S., Zhao, B."Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer". Molecular and Clinical Oncology 4, no. 3 (2016): 441-449. https://doi.org/10.3892/mco.2015.712
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