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Article

Triple-negative breast cancer exhibits a favorable response to neoadjuvant chemotherapy independent of the expression of topoisomerase Ⅱα

  • Authors:
    • Hiroko Nogi
    • Ken Uchida
    • Makiko Kamio
    • Kumiko Kato
    • Yasuo Toriumi
    • Tadashi Akiba
    • Toshiaki Morikawa
    • Masaaki Suzuki
    • Tadashi Kobayashi
    • Hiroshi Takeyama
  • View Affiliations / Copyright

    Affiliations: Department of Breast and Endocrine Surgery, The Jikei University School of Medicine, Minato‑ku, Tokyo 105‑8461, Japan, Department of Surgery, The Jikei University School of Medicine, Minato‑ku, Tokyo 105‑8461, Japan, Department of Thoracic Surgery, The Jikei University School of Medicine, Minato‑ku, Tokyo 105‑8461, Japan, Department of Pathology, The Jikei University School of Medicine, Minato‑ku, Tokyo 105‑8461, Japan, Department of Medical Oncology and Hematology, The Jikei University School of Medicine, Minato‑ku, Tokyo 105‑8461, Japan
  • Pages: 383-389
    |
    Published online on: December 21, 2015
       https://doi.org/10.3892/mco.2015.719
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Abstract

The present study retrospectively analyzed the utility of topoisomerase Ⅱα expression as a prognostic marker to predict the neoadjuvant chemotherapeutic response and survival among different breast cancer subtypes. The patients were subtyped and the expression of topoisomerase Ⅱα was determined using immunohistochemistry. All patients (n=147) received an anthracycline-containing regimen preoperatively, and 139 (95%) patients also received docetaxel. Of the 147 patients, 25 (17%) were triple-negative and 20 (17%) were human epidermal growth factor receptor 2 (HER2)-positive. Among these subtypes, a significantly higher a rate (P<0.0001) and higher incidence of topoisomerase Ⅱα expression (P=0.036) were observed compared with that in the hormone receptor‑positive and HER2‑negative breast cancer types. However, the expression of topoisomerase Ⅱα revealed no correlation with the treatment response or survival in any of the subtypes. Therefore, these results indicated that the favorable response to anthracycline-containing chemotherapy among triple-negative and HER2‑positive breast cancer was independent of the expression of topoisomerase Ⅱα.
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Copy and paste a formatted citation
Spandidos Publications style
Nogi H, Uchida K, Kamio M, Kato K, Toriumi Y, Akiba T, Morikawa T, Suzuki M, Kobayashi T, Takeyama H, Takeyama H, et al: Triple-negative breast cancer exhibits a favorable response to neoadjuvant chemotherapy independent of the expression of topoisomerase Ⅱα. Mol Clin Oncol 4: 383-389, 2016.
APA
Nogi, H., Uchida, K., Kamio, M., Kato, K., Toriumi, Y., Akiba, T. ... Takeyama, H. (2016). Triple-negative breast cancer exhibits a favorable response to neoadjuvant chemotherapy independent of the expression of topoisomerase Ⅱα. Molecular and Clinical Oncology, 4, 383-389. https://doi.org/10.3892/mco.2015.719
MLA
Nogi, H., Uchida, K., Kamio, M., Kato, K., Toriumi, Y., Akiba, T., Morikawa, T., Suzuki, M., Kobayashi, T., Takeyama, H."Triple-negative breast cancer exhibits a favorable response to neoadjuvant chemotherapy independent of the expression of topoisomerase Ⅱα". Molecular and Clinical Oncology 4.3 (2016): 383-389.
Chicago
Nogi, H., Uchida, K., Kamio, M., Kato, K., Toriumi, Y., Akiba, T., Morikawa, T., Suzuki, M., Kobayashi, T., Takeyama, H."Triple-negative breast cancer exhibits a favorable response to neoadjuvant chemotherapy independent of the expression of topoisomerase Ⅱα". Molecular and Clinical Oncology 4, no. 3 (2016): 383-389. https://doi.org/10.3892/mco.2015.719
Copy and paste a formatted citation
x
Spandidos Publications style
Nogi H, Uchida K, Kamio M, Kato K, Toriumi Y, Akiba T, Morikawa T, Suzuki M, Kobayashi T, Takeyama H, Takeyama H, et al: Triple-negative breast cancer exhibits a favorable response to neoadjuvant chemotherapy independent of the expression of topoisomerase Ⅱα. Mol Clin Oncol 4: 383-389, 2016.
APA
Nogi, H., Uchida, K., Kamio, M., Kato, K., Toriumi, Y., Akiba, T. ... Takeyama, H. (2016). Triple-negative breast cancer exhibits a favorable response to neoadjuvant chemotherapy independent of the expression of topoisomerase Ⅱα. Molecular and Clinical Oncology, 4, 383-389. https://doi.org/10.3892/mco.2015.719
MLA
Nogi, H., Uchida, K., Kamio, M., Kato, K., Toriumi, Y., Akiba, T., Morikawa, T., Suzuki, M., Kobayashi, T., Takeyama, H."Triple-negative breast cancer exhibits a favorable response to neoadjuvant chemotherapy independent of the expression of topoisomerase Ⅱα". Molecular and Clinical Oncology 4.3 (2016): 383-389.
Chicago
Nogi, H., Uchida, K., Kamio, M., Kato, K., Toriumi, Y., Akiba, T., Morikawa, T., Suzuki, M., Kobayashi, T., Takeyama, H."Triple-negative breast cancer exhibits a favorable response to neoadjuvant chemotherapy independent of the expression of topoisomerase Ⅱα". Molecular and Clinical Oncology 4, no. 3 (2016): 383-389. https://doi.org/10.3892/mco.2015.719
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