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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Stromal expression of matrix metalloproteinase 2 in cancer-associated fibroblasts is strongly related to human epidermal growth factor receptor 2 status in invasive breast carcinoma

  • Authors:
    • Xavier Catteau
    • Philippe Simon
    • Jean‑Christophe Noël
  • View Affiliations / Copyright

    Affiliations: Institute of Pathology and Genetics, B-6041 Gosselies, Belgium, Faculty of Medicine, Université Libre de Bruxelles, B-1070 Brussels, Belgium
  • Pages: 375-378
    |
    Published online on: December 24, 2015
       https://doi.org/10.3892/mco.2015.721
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Abstract

The peritumoral stroma and cancer-associated fibroblasts (CAFs) have been suggested to play an important role in breast tumorigenesis. The specific immunohistochemical characteristics of the stromal component according to the breast carcinoma subtype surrogates of molecular classes is poorly understood. In the present study, immunohistochemical staining was used to evaluate the expression of matrix metalloproteinase 2 (MMP2), which is one of the most important proteins considered to facilitate tumor invasion, in a series of invasive breast carcinomas according to subtype: luminal A, luminal B, luminal‑HER2, HER2‑enriched and triple‑negative. a significant increase in MMP2 expression was demonstrated in tumors known to exhibit a more aggressive metastatic behavior, such as luminal HER2 (37%), HER2‑enriched (30%) and triple‑negative tumors (17%), compared with the luminal A (6%) or luminal B (13%) subtypes. Our data indicated that the CAFs associated with different breast subtypes exhibit different specific properties to facilitate tumor invasion.
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Copy and paste a formatted citation
Spandidos Publications style
Catteau X, Simon P and Noël JC: Stromal expression of matrix metalloproteinase 2 in cancer-associated fibroblasts is strongly related to human epidermal growth factor receptor 2 status in invasive breast carcinoma. Mol Clin Oncol 4: 375-378, 2016.
APA
Catteau, X., Simon, P., & Noël, J. (2016). Stromal expression of matrix metalloproteinase 2 in cancer-associated fibroblasts is strongly related to human epidermal growth factor receptor 2 status in invasive breast carcinoma. Molecular and Clinical Oncology, 4, 375-378. https://doi.org/10.3892/mco.2015.721
MLA
Catteau, X., Simon, P., Noël, J."Stromal expression of matrix metalloproteinase 2 in cancer-associated fibroblasts is strongly related to human epidermal growth factor receptor 2 status in invasive breast carcinoma". Molecular and Clinical Oncology 4.3 (2016): 375-378.
Chicago
Catteau, X., Simon, P., Noël, J."Stromal expression of matrix metalloproteinase 2 in cancer-associated fibroblasts is strongly related to human epidermal growth factor receptor 2 status in invasive breast carcinoma". Molecular and Clinical Oncology 4, no. 3 (2016): 375-378. https://doi.org/10.3892/mco.2015.721
Copy and paste a formatted citation
x
Spandidos Publications style
Catteau X, Simon P and Noël JC: Stromal expression of matrix metalloproteinase 2 in cancer-associated fibroblasts is strongly related to human epidermal growth factor receptor 2 status in invasive breast carcinoma. Mol Clin Oncol 4: 375-378, 2016.
APA
Catteau, X., Simon, P., & Noël, J. (2016). Stromal expression of matrix metalloproteinase 2 in cancer-associated fibroblasts is strongly related to human epidermal growth factor receptor 2 status in invasive breast carcinoma. Molecular and Clinical Oncology, 4, 375-378. https://doi.org/10.3892/mco.2015.721
MLA
Catteau, X., Simon, P., Noël, J."Stromal expression of matrix metalloproteinase 2 in cancer-associated fibroblasts is strongly related to human epidermal growth factor receptor 2 status in invasive breast carcinoma". Molecular and Clinical Oncology 4.3 (2016): 375-378.
Chicago
Catteau, X., Simon, P., Noël, J."Stromal expression of matrix metalloproteinase 2 in cancer-associated fibroblasts is strongly related to human epidermal growth factor receptor 2 status in invasive breast carcinoma". Molecular and Clinical Oncology 4, no. 3 (2016): 375-378. https://doi.org/10.3892/mco.2015.721
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