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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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November-2016 Volume 5 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Case Report

Favorable control of advanced colon adenocarcinoma with severe bone marrow metastasis: A case report

  • Authors:
    • Fumiyasu Hanamura
    • Yoshihiro Shibata
    • Tsuyoshi Shirakawa
    • Miyuki Kuwayama
    • Hisanobu Oda
    • Hiroshi Ariyama
    • Kenichi Taguchi
    • Taito Esaki
    • Eishi Baba
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Fukuoka Wajiro Hospital, Fukuoka 811‑021, Japan, Department of Gastrointestinal and Medical Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811‑1395, Japan, Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812‑8582, Japan, Department of Cancer Biology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811‑1395, Japan, Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812‑8582, Japan
  • Pages: 579-582
    |
    Published online on: September 21, 2016
       https://doi.org/10.3892/mco.2016.1029
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Abstract

Colorectal cancer (CRC) has a propensity to metastasize to the liver, lungs and regional abdominal lymph nodes, but rarely to the bone marrow. A 60‑year‑old man presented to the National Hospital Organization Kyushu Cancer Center with a 4‑week history of persistent lower back pain, anorexia and difficulty defecating. Complete blood count revealed severe thrombocytopenia and erythroblastosis, suggesting a hematological malignancy. However, the bone marrow examination demonstrated involvement by a moderately to poorly differentiated adenocarcinoma, but no hematopoietic abnormalities. A computed tomography scan revealed thickening of the wall of the sigmoid colon, with para‑aortic, hilar, mediastinal and supraclavicular lymphadenopathy. The patient was thus diagnosed with sigmoid colon adenocarcinoma with lymph node and bone marrow metastasis. Modified FOLFOX6 was promptly initiated, with concurrent therapy for disseminated intravascular coagulation (DIC). An increased number of thrombocytes was observed on day 6. After 3 cycles of treatment, the patient recovered from DIC and the levels of serum carcinoembryonic antigen and cytokeratin 19 fragment were decreased. Tumor biopsy during colonoscopy following recovery from DIC demonstrated poorly differentiated adenocarcinoma with mucin production, without mutations in the RAS, BRAF or PIK3CA genes, and a cytokeratin (CK) 7‑negative, CK20‑positive phenotype. The patient has been treated with chemotherapy for 150 days without disease progression. However, the efficacy of chemotherapy for rarely encountered bone marrow metastasis from CRC is poor. The present case was favorably maintained on chemotherapy and survived for 10 months.
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Copy and paste a formatted citation
Spandidos Publications style
Hanamura F, Shibata Y, Shirakawa T, Kuwayama M, Oda H, Ariyama H, Taguchi K, Esaki T and Baba E: Favorable control of advanced colon adenocarcinoma with severe bone marrow metastasis: A case report. Mol Clin Oncol 5: 579-582, 2016.
APA
Hanamura, F., Shibata, Y., Shirakawa, T., Kuwayama, M., Oda, H., Ariyama, H. ... Baba, E. (2016). Favorable control of advanced colon adenocarcinoma with severe bone marrow metastasis: A case report. Molecular and Clinical Oncology, 5, 579-582. https://doi.org/10.3892/mco.2016.1029
MLA
Hanamura, F., Shibata, Y., Shirakawa, T., Kuwayama, M., Oda, H., Ariyama, H., Taguchi, K., Esaki, T., Baba, E."Favorable control of advanced colon adenocarcinoma with severe bone marrow metastasis: A case report". Molecular and Clinical Oncology 5.5 (2016): 579-582.
Chicago
Hanamura, F., Shibata, Y., Shirakawa, T., Kuwayama, M., Oda, H., Ariyama, H., Taguchi, K., Esaki, T., Baba, E."Favorable control of advanced colon adenocarcinoma with severe bone marrow metastasis: A case report". Molecular and Clinical Oncology 5, no. 5 (2016): 579-582. https://doi.org/10.3892/mco.2016.1029
Copy and paste a formatted citation
x
Spandidos Publications style
Hanamura F, Shibata Y, Shirakawa T, Kuwayama M, Oda H, Ariyama H, Taguchi K, Esaki T and Baba E: Favorable control of advanced colon adenocarcinoma with severe bone marrow metastasis: A case report. Mol Clin Oncol 5: 579-582, 2016.
APA
Hanamura, F., Shibata, Y., Shirakawa, T., Kuwayama, M., Oda, H., Ariyama, H. ... Baba, E. (2016). Favorable control of advanced colon adenocarcinoma with severe bone marrow metastasis: A case report. Molecular and Clinical Oncology, 5, 579-582. https://doi.org/10.3892/mco.2016.1029
MLA
Hanamura, F., Shibata, Y., Shirakawa, T., Kuwayama, M., Oda, H., Ariyama, H., Taguchi, K., Esaki, T., Baba, E."Favorable control of advanced colon adenocarcinoma with severe bone marrow metastasis: A case report". Molecular and Clinical Oncology 5.5 (2016): 579-582.
Chicago
Hanamura, F., Shibata, Y., Shirakawa, T., Kuwayama, M., Oda, H., Ariyama, H., Taguchi, K., Esaki, T., Baba, E."Favorable control of advanced colon adenocarcinoma with severe bone marrow metastasis: A case report". Molecular and Clinical Oncology 5, no. 5 (2016): 579-582. https://doi.org/10.3892/mco.2016.1029
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