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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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December-2016 Volume 5 Issue 6

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Case Report

A case report of primary cutaneous natural killer/T‑cell lymphoma

  • Authors:
    • Chen Tian
    • Yong Yu
    • Yizhuo Zhang
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, P.R. China
  • Pages: 777-778
    |
    Published online on: October 4, 2016
       https://doi.org/10.3892/mco.2016.1042
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Abstract

Primary cutaneous extranodal natural killer/T‑cell lymphoma, nasal type (ENKL‑NT) is a relatively rare disease associated with aggressive tumor‑cell behavior and poor prognosis. Progress in immunohistochemistry has improved the identification of ENKL‑NT. The present case study reported on a 64‑year‑old female patient presenting with several red nodular lesions on the neck developed over four months. Cutaneous biopsy revealed these cells were positive for CD3, CD56, CD5, CD8 and negative for CD2, CD34, CD7, CD20 and Granzyme B. A computed tomography scan and bone marrow biopsy did not show any abnormalities and a diagnosis of primary cutaneous ENKL‑NT was made. After treatment with chemotherapy regimens comprising cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP), followed by high‑dose treatment with methotrexate, dexamethasone, ifosfamide, etoposide and L‑asparaginasum (SMILE), the patient succumbed to the disease. The present study exemplified that immunohistochemical analysis as well as the recognition of atypical lymphoid cells showing angiocentricity is crucial for the correct diagnosis of ENKL‑NT. The prognosis of primary cutaneous ENKL‑NT remains poor. As the CHOP regimen is not completely effective, high‑dose chemotherapy, such as the SMILE regimen, is required.
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Copy and paste a formatted citation
Spandidos Publications style
Tian C, Yu Y and Zhang Y: A case report of primary cutaneous natural killer/T‑cell lymphoma. Mol Clin Oncol 5: 777-778, 2016.
APA
Tian, C., Yu, Y., & Zhang, Y. (2016). A case report of primary cutaneous natural killer/T‑cell lymphoma. Molecular and Clinical Oncology, 5, 777-778. https://doi.org/10.3892/mco.2016.1042
MLA
Tian, C., Yu, Y., Zhang, Y."A case report of primary cutaneous natural killer/T‑cell lymphoma". Molecular and Clinical Oncology 5.6 (2016): 777-778.
Chicago
Tian, C., Yu, Y., Zhang, Y."A case report of primary cutaneous natural killer/T‑cell lymphoma". Molecular and Clinical Oncology 5, no. 6 (2016): 777-778. https://doi.org/10.3892/mco.2016.1042
Copy and paste a formatted citation
x
Spandidos Publications style
Tian C, Yu Y and Zhang Y: A case report of primary cutaneous natural killer/T‑cell lymphoma. Mol Clin Oncol 5: 777-778, 2016.
APA
Tian, C., Yu, Y., & Zhang, Y. (2016). A case report of primary cutaneous natural killer/T‑cell lymphoma. Molecular and Clinical Oncology, 5, 777-778. https://doi.org/10.3892/mco.2016.1042
MLA
Tian, C., Yu, Y., Zhang, Y."A case report of primary cutaneous natural killer/T‑cell lymphoma". Molecular and Clinical Oncology 5.6 (2016): 777-778.
Chicago
Tian, C., Yu, Y., Zhang, Y."A case report of primary cutaneous natural killer/T‑cell lymphoma". Molecular and Clinical Oncology 5, no. 6 (2016): 777-778. https://doi.org/10.3892/mco.2016.1042
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