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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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December-2016 Volume 5 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Case Report

Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report

  • Authors:
    • Nobuhisa Matsuhashi
    • Takao Takahashi
    • Junko Kato
    • Toshiyuki Tanahashi
    • Satoshi Matsui
    • Yoshiyuki Sasaki
    • Hisashi Imai
    • Yoshihiro Tanaka
    • Naoki Okumura
    • Kazuya Yamaguchi
    • Manabu Futamura
    • Shinji Osada
    • Kazuhiro Yoshida
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Gifu University School of Medicine, Gifu 501‑1194, Japan
  • Pages: 807-810
    |
    Published online on: October 5, 2016
       https://doi.org/10.3892/mco.2016.1045
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Abstract

Pathological response to preoperative chemotherapy was recently found to be correlated with improved survival and has been proposed as a new outcome end‑point following resection of liver metastases from colorectal cancer (CRC). It was demonstrated that, particularly after therapy with bevacizumab, CRC liver metastases decreased in size and underwent distinct morphological changes on computed tomography (CT). However, morphological changes in response to treatment with regorafenib have not yet been reported. A 74‑year‑old male patient with synchronous multiple liver and lung metastases from colon cancer was treated with regorafenib as a fifth‑line therapy. CT imaging revealed a decrease in the tumor size and distinct morphological changes, namely homogeneous attenuation and sharp tumor‑liver interface. The patient continued to take regorafenib for 8 months. Thus, regorafenib appeared to be effective as a last‑line chemotherapy. In particular, the unique morphological changes of the metastases on CT imaging of may represent a method for evaluating the effects of crc cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Matsuhashi N, Takahashi T, Kato J, Tanahashi T, Matsui S, Sasaki Y, Imai H, Tanaka Y, Okumura N, Yamaguchi K, Yamaguchi K, et al: Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report. Mol Clin Oncol 5: 807-810, 2016.
APA
Matsuhashi, N., Takahashi, T., Kato, J., Tanahashi, T., Matsui, S., Sasaki, Y. ... Yoshida, K. (2016). Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report. Molecular and Clinical Oncology, 5, 807-810. https://doi.org/10.3892/mco.2016.1045
MLA
Matsuhashi, N., Takahashi, T., Kato, J., Tanahashi, T., Matsui, S., Sasaki, Y., Imai, H., Tanaka, Y., Okumura, N., Yamaguchi, K., Futamura, M., Osada, S., Yoshida, K."Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report". Molecular and Clinical Oncology 5.6 (2016): 807-810.
Chicago
Matsuhashi, N., Takahashi, T., Kato, J., Tanahashi, T., Matsui, S., Sasaki, Y., Imai, H., Tanaka, Y., Okumura, N., Yamaguchi, K., Futamura, M., Osada, S., Yoshida, K."Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report". Molecular and Clinical Oncology 5, no. 6 (2016): 807-810. https://doi.org/10.3892/mco.2016.1045
Copy and paste a formatted citation
x
Spandidos Publications style
Matsuhashi N, Takahashi T, Kato J, Tanahashi T, Matsui S, Sasaki Y, Imai H, Tanaka Y, Okumura N, Yamaguchi K, Yamaguchi K, et al: Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report. Mol Clin Oncol 5: 807-810, 2016.
APA
Matsuhashi, N., Takahashi, T., Kato, J., Tanahashi, T., Matsui, S., Sasaki, Y. ... Yoshida, K. (2016). Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report. Molecular and Clinical Oncology, 5, 807-810. https://doi.org/10.3892/mco.2016.1045
MLA
Matsuhashi, N., Takahashi, T., Kato, J., Tanahashi, T., Matsui, S., Sasaki, Y., Imai, H., Tanaka, Y., Okumura, N., Yamaguchi, K., Futamura, M., Osada, S., Yoshida, K."Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report". Molecular and Clinical Oncology 5.6 (2016): 807-810.
Chicago
Matsuhashi, N., Takahashi, T., Kato, J., Tanahashi, T., Matsui, S., Sasaki, Y., Imai, H., Tanaka, Y., Okumura, N., Yamaguchi, K., Futamura, M., Osada, S., Yoshida, K."Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report". Molecular and Clinical Oncology 5, no. 6 (2016): 807-810. https://doi.org/10.3892/mco.2016.1045
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