Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
January-2017 Volume 6 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2017 Volume 6 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Correlation of Nedd4-1 and PTEN expression with the invasive capacity of pituitary adenomas

  • Authors:
    • Jing Zhang
    • Xin Li
    • Yanyan Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Heze Municipal Hospital, Heze, Shandong 274000, P.R. China, Department of Neurosurgery, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, P.R. China
  • Pages: 96-100
    |
    Published online on: November 24, 2016
       https://doi.org/10.3892/mco.2016.1092
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to correlate the expression of neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) with the invasive capacity of pituitary adenomas. A total of 50 pituitary adenoma tissues and 10 normal pituitary tissues were divided into the invasive group (26 cases), the non‑invasive group (24 cases) and the normal group (10 cases). The expression of NEDD4‑1 and PTEN was determined by immunohistochemistry. NEDD4‑1 was revealed to be located in the nucleus and cytoplasm, whereas PTEN was only located in the cytoplasm. Furthermore, expression of NEDD4‑1 was higher in pituitary adenomas compared with normal pituitary tissues (P<0.05), and higher in the invasive group compared with the non‑invasive group, whereas the opposite trend was observed for PTEN. There was a strong negative correlation between NEDD4‑1 and PTEN expression, indicating a dependency between the two and an association with invasiveness. In conclusion, NEDD4‑1 may serve as a diagnostic and prognostic factor, and as a novel therapeutic target, in pituitary adenomas.
View Figures

Figure 1

Figure 2

View References

1 

Palumbo T, Faucz FR, Azevedo M, Xekouki P, Iliopoulos D and Stratakis CA: Functional screen analysis reveals miR-26b and miR-128 as central regulators of pituitary somatomammotrophic tumor growth through activation of the PTEN-AKT pathway. Oncogene. 32:1651–1659. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Li DM and Sun H: TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor-β. Cancer Res. 57:2124–2129. 1997.PubMed/NCBI

3 

Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, et al: PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 275:1943–1947. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, et al: NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell. 128:129–139. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Wu DN, Pei DS, Wang Q and Zhang GY: Down-regulation of PTEN by sodium orthovanadate inhibits ASK1 activation via PI3-K/AKT during cerebral ischemia in rat hippocampus. Neurosci Lett. 404:98–102. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Castellino RC and Durden DL: Mechanisms of disease: The PI3K-AKT-PTEN signaling node - an intercept point for the control of angiogenesis in brain tumors. Nat Clin Pract Neurol. 3:682–693. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Tena-Suck ML, Ortiz-Plata A and de la Vega HA: Phosphatase and tensin homologue and pituitary tumor-transforming gene in pituitary adenomas. Clinical-pathologic and immunohistochemical analysis. Ann Diagn Pathol. 12:275–282. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Feng ZZ, Chen JW, Yang ZR, Lu GZ and Cai ZG: Expression of PTTG1 and PTEN in endometrial carcinoma: Correlation with tumorigenesis and progression. Med Oncol. 29:304–310. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Li X, Li M, Tian X, Li Q, Lu Q, Jia Q, Zhang L, Yan J and Li X and Li X: Golgi phosphoprotein 3 inhibits the apoptosis of human glioma cells in part by downregulating N-myc downstream regulated gene 1. Med Sci Monit. 22:3535–3543. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Vivanco I and Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer. 2:489–501. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Whiteman DC, Zhou XP, Cummings MC, Pavey S, Hayward NK and Eng C: Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma. Int J Cancer. 99:63–67. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Ahmed S Faisal, Marsh DJ, Weremowicz S, Morton CC, Williams DM and Eng C: Balanced translocation of 10q and 13q, including the PTEN gene, in a boy with a human chorionic gonadotropin-secreting tumor and the Bannayan-Riley-Ruvalcaba syndrome. J Clin Endocrinol Metab. 84:4665–4670. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Wu LM, Li YL, Yin YH, Hou GQ, Zhu R, Hua XL, Xu JR and Chen ZA: Usefulness of dual-energy computed tomography imaging in the differential diagnosis of sellar meningiomas and pituitary adenomas: Preliminary report. PLoS One. 9:e906582014. View Article : Google Scholar : PubMed/NCBI

14 

Cao XR, Lill NL, Boase N, Shi PP, Croucher DR, Shan H, Qu J, Sweezer EM, Place T, Kirby PA, et al: Nedd4 controls animal growth by regulating IGF-1 signaling. Sci Signal. 1:ra52008. View Article : Google Scholar : PubMed/NCBI

15 

Treier M, Staszewski LM and Bohmann D: Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell. 78:787–798. 1994. View Article : Google Scholar : PubMed/NCBI

16 

Chou TC: Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev. 58:621–681. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Franke TF, Kaplan DR, Cantley LC and Toker A: Direct regulation of the Akt proto-oncogene product by phosphatidylinositol 3,4-bisphosphate. Science. 275:665–668. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Wang L, Balas B, Christ-Roberts CY, Kim RY, Ramos FJ, Kikani CK, Li C, Deng C, Reyna S, Musi N, et al: Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo. Mol Cell Biol. 27:6497–6505. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Yim EK, Peng G, Dai H, Hu R, Li K, Lu Y, Mills GB, Meric-Bernstam F, Hennessy BT, Craven RJ and Lin SY: Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell. 15:304–314. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Drinjakovic J, Jung H, Campbell DS, Strochlic L, Dwivedy A and Holt CE: E3 ligase Nedd4 promotes axon branching by down-regulating PTEN. Neuron. 65:341–357. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H, Pavletich NP, Carver BS, Cordon-Cardo C, Erdjument-Bromage H, et al: Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell. 128:141–156. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Maccario H, Perera NM, Gray A, Downes CP and Leslie NR: Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress. J Biol Chem. 285:12620–12628. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Wang X, Shi Y, Wang J, Huang G and Jiang X: Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation. Biochem J. 414:221–229. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Lee JR, Oestreich AJ, Payne JA, Gunawan MS, Norgan AP and Katzmann DJ: The HECT domain of the ubiquitin ligase Rsp5 contributes to substrate recognition. J Biol Chem. 284:32126–32137. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Kim RH, Peters M, Jang Y, Shi W, Pintilie M, Fletcher GC, DeLuca C, Liepa J, Zhou L, Snow B, et al: DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell. 7:263–273. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Li X and Zhang Y: Correlation of Nedd4-1 and PTEN expression with the invasive capacity of pituitary adenomas. Mol Clin Oncol 6: 96-100, 2017.
APA
Zhang, J., Li, X., & Zhang, Y. (2017). Correlation of Nedd4-1 and PTEN expression with the invasive capacity of pituitary adenomas. Molecular and Clinical Oncology, 6, 96-100. https://doi.org/10.3892/mco.2016.1092
MLA
Zhang, J., Li, X., Zhang, Y."Correlation of Nedd4-1 and PTEN expression with the invasive capacity of pituitary adenomas". Molecular and Clinical Oncology 6.1 (2017): 96-100.
Chicago
Zhang, J., Li, X., Zhang, Y."Correlation of Nedd4-1 and PTEN expression with the invasive capacity of pituitary adenomas". Molecular and Clinical Oncology 6, no. 1 (2017): 96-100. https://doi.org/10.3892/mco.2016.1092
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Li X and Zhang Y: Correlation of Nedd4-1 and PTEN expression with the invasive capacity of pituitary adenomas. Mol Clin Oncol 6: 96-100, 2017.
APA
Zhang, J., Li, X., & Zhang, Y. (2017). Correlation of Nedd4-1 and PTEN expression with the invasive capacity of pituitary adenomas. Molecular and Clinical Oncology, 6, 96-100. https://doi.org/10.3892/mco.2016.1092
MLA
Zhang, J., Li, X., Zhang, Y."Correlation of Nedd4-1 and PTEN expression with the invasive capacity of pituitary adenomas". Molecular and Clinical Oncology 6.1 (2017): 96-100.
Chicago
Zhang, J., Li, X., Zhang, Y."Correlation of Nedd4-1 and PTEN expression with the invasive capacity of pituitary adenomas". Molecular and Clinical Oncology 6, no. 1 (2017): 96-100. https://doi.org/10.3892/mco.2016.1092
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team