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Review

Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis (Review)

  • Authors:
    • Wan‑Jun Yan
    • Xing‑Cong Ma
    • Xiao‑Yan Gao
    • Xing‑Huan Xue
    • Shu‑Qun Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Second Affiliated Hospital, College of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 472-476
    |
    Published online on: January 28, 2016
       https://doi.org/10.3892/mco.2016.750
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Abstract

Breast cancer is one of the most commonly occurring female malignant tumors. According to the 2012 GLOBOCAN statistics, produced by the International Agency for Research On Cancer (ʻIARCʼ), nearly 1.7 million women were diagnosed with breast cancer, with 522,000 related deaths: An increase in the incidence of breast cancer and associated mortality by nearly 18% from 2008. Metastasis is the final step in breast cancer progression, and represents the most common cause of mortality in patients with breast cancer. Therefore, a search for low‑toxicity, safe and effective anti‑breast cancer drugs in the form of natural compounds has become an intense focus of research. Baicalein, a widely used Chinese herbal medicine, has extensive antitumor activity. The present review briefly describes the research that has been performed on the association between baicalein and breast cancer metastasis, and further illustrates the influence of baicalein on the underlying mechanisms of breast cancer metastasis, adding a novel theory basis for baicalein antitumor research. In conclusion, baicalein may represent a promising target for the prevention and therapy of breast cancer.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Kim SR and Paik S: Genomics of adjuvant therapy for breast cancer. Cancer. 17:500–504. 2011. View Article : Google Scholar

3 

Serpa R, França EJ, Furlaneto-Maia L, Andrade CG, Diniz A and Furlaneto MC: In vitro antifungal activity of the flavonoid baicalein against Candida species. J Med Microbiol. 61:1704–1708. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Zhang H, Tian K, Tang J, Qi S, Chen H, Chen X and Hu Z: Analysis of baicalein, baicalin and wogonin in Scutellariae radix and its preparation by microemulsion electrokinetic chromatography with 1-butyl-3-methylimizolium tetrafluoborate ionic liquid as additive. J Chromatogr A. 11:304–307. 2006. View Article : Google Scholar

5 

Wang HW, Lin CP, Chiu JH, Chow KC, Kuo KT, Lin CS and Wang LS: Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin. Int J Cancer. 1:2019–2027. 2007. View Article : Google Scholar

6 

Chen L, Dou J, Su Z, Zhou H, Wang H, Zhou W, Guo Q and Zhou C: Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice. Antiviral Res. 91:314–320. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Li-Weber M: New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev. 35:57–68. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Zhang HB, Lu P, Guo QY, Zhang ZH and Meng XY: Baicalein induces apoptosis in esophageal squamous cell carcinoma cells through modulation of the PI3K/Akt pathway. Oncol Lett. 5:722–728. 2013.PubMed/NCBI

9 

Liu YF, Gao F, Li XW, Jia RH, Meng XD, Zhao R, Jing YY, Wang Y and Jiang W: The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats. Neurochem Res. 37:1670–1680. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Zhang K, Guo QL, You QD, Yang Y, Zhang HW, Yang L, Gu HY, Qi Q, Tan Z and Wang X: Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. Cancer Sci. 99:689–695. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Wu YL, Lian LH, Wan Y and Nan JX: Baicalein inhibits nuclear factor-B and apoptosis via c-FLIP and MAPK in d-GalN/LPS induced acute liver failure in murine models. Chem Biol Interact. 188:526–534. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Peng Ju, Xu Wen-Jie, HE Bi-Xia, et al: Effects of baicalein on rat myocardial ischemia and neonatal cardiomyocyte injury. Chin J Nat Med. 9:132–140. 2011.

13 

Lea MA, Ibeh C, Deutsch JK, Hamid I and desBordes C: Inhibition of growth and induction of alkaline phosphatase in colon cancer cells by flavonols and flavonol glycosides. Anticancer Res. 30:3629–3635. 2010.PubMed/NCBI

14 

Niknami M, Vignarajan S, Yao M, Hua S, Witting PK, Kita Y, Shimizu T, Sved P, Patel MI and Dong Q: Decrease in expression or activity of cytosolic phospholipase A2alpha increases cyclooxygenase-1 action: A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells. Biochim Biophys Acta. 1801:731–737. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Chen K, Zhang S, Ji Y, Li J, An P, Ren H, Liang R, Yang J and Li Z: Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway. PLoS One. 8:e729272013. View Article : Google Scholar : PubMed/NCBI

16 

Wu B, Li J, Huang D, Wang W, Chen Y, Liao Y, Tang X, Xie H and Tang F: Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells. BMC Cancer. 11:5272011. View Article : Google Scholar : PubMed/NCBI

17 

Wei X, Guo W, Wu S, Wang L, Huang P, Liu J and Fang B: Oxidative stress in NSC-741909-induced apoptosis of cancer cells. J Transl Med. 8:372010. View Article : Google Scholar : PubMed/NCBI

18 

Shang D, Li Z, Zhu Z, Chen H, Zhao L, Wang X and Chen Y: Baicalein suppresses 17-β-estradiol-induced migration, adhesion and invasion of breast cancer cells via the G protein-coupled receptor 30 signaling pathway. Oncol Rep. 33:2077–2085. 2015.PubMed/NCBI

19 

Zhang K, Guo QL, You QD, Yang Y, Zhang HW, Yang L, Gu HY, Qi Q, Tan Z and Wang X: Wogonin induces the granulocytic differention of human NB4 promyelocytic leukemia cells and up-regulates phospolipid scramblase 1 gene expression. Cancer Sci. 99:689–695. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Wang L, Ling Y, Chen Y, Li CL, Feng F, You QD, Lu N and Guo QL: Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells. Cancer Lett. 297:42–48. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Xu W, Xiao L, Ma Y, et al: Baicalein mediates influence of proliferation of breast cancer MCF-7 and MDA-MB-231 cells. The Chinese Medicine. 14:26–28. 2011.

22 

Wang N, Ren D, Deng S and Yang X: Differential effects of baicalein and its sulfated derivatives in inhibiting proliferation of human breast cancer MCF-7 cells. Chem Biol Interact. 221:99–108. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Zhou QM, Wang S, Zhang H, Lu YY, Wang XF, Motoo Y and Su SB: The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells. Acta Pharmacol Sin. 30:1648–1658. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Lee JH, Li YC, Ip SW, Hsu SC, Chang NW, Tang NY, Yu CS, Chou ST, Lin SS, Lino CC, et al: The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway. Anticancer Res. 28:1701–1711. 2008.PubMed/NCBI

25 

Gao MH, Lin ZH, Xu YJ, et al: Baicalein mediates influence of proliferation and migration of breast cancer MDA-MB-231 cells. Lishizhen Medicine and Materia Medica Research. 24:1389–1390. 2013.

26 

Nam KS and Shon YH: Suppression of metastasis of human breast cancer cells by chitosan oligosaccharides. J Microbiol Biotechnol. 19:629–633. 2009.PubMed/NCBI

27 

Yan C and Boyd DD: Regulation of matrix metalloproteinase gene expression. J Cell Physiol. 211:19–26. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Lu N, Ling Y, Gao Y, Chen Y, Mu R, Qi Q, Liu W, Zhang H, Gu H, Wang S, et al: Endostar suppresses invasion through downregulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells. Exp Biol Med (Maywood). 233:1013–1020. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Jones JL, Shaw JA, Pringle JH and Walker RA: Primary breast myoepithelial cells exert an invasion-suppressor effect on breast cancer cells via paracrine down-regulation of MMP expression in fibroblasts and tumour cells. J Pathol. 201:562–572. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Aye MM, Ma C, Lin H, Bower KA, Wiggins RC and Luo J: Ethanol-induced in vitro invasion of breast cancer cells: The contribution of MMP-2 by fibroblasts. Int J Cancer. 112:738–746. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Ibrahim A, El-Meligy A, Fetaih H, Dessouki A, Stoica G and Barhoumi R: Effect of curcumin and Meriva on the lung metastasis of murine mammary gland adenocarcinoma. In Vivo. 24:401–408. 2010.PubMed/NCBI

32 

Iwatsuki M, Mimori K, Yokobori T, Ishi H, Beppu T, Nakamori S, Baba H and Mori M: Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci. 101:293–299. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2:442–454. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Zavadil J and Böttinger EP: TGF-beta and epithelial-to-mesenchymal transitions. Oncogene. 24:5764–5774. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Kamaraju AK and Roberts AB: Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-beta-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo. J Biol Chem. 280:1024–1036. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Lee JM, Dedhar S, Kalluri R and Thompson EW: The epithelial-mesenchymal transition: New insights in signaling, development and disease. J Cell Biol. 72:973–981. 2006. View Article : Google Scholar

37 

Chung H, Choi HS, Seo EK, Kang DH and Oh ES: Baicalin and baicalein inhibit transforming growth factor-β1-mediated epithelial-mesenchymal transition in human breast epithelial cells. Biochem Biophys Res Commun. 458:707–713. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Han HJ, Russo J, Kohwi Y and Kohwi-Shigematsu T: SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. Nature. 452:187–193. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Prat A, Parker JS, Karginova O, Fan C, Livasy C, Herschkowitz JI, He X and Perou CM: Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Research. 12:R682010. View Article : Google Scholar : PubMed/NCBI

40 

Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD, Viale A, Olshen AB, Gerald WL and Massagué J: Genes that mediate breast cancer metastasis to lung. Nature. 436:518–524. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordón-Cardo C, Guise TA and Massagué J: A multigenic program mediating breast cancer metastasis to bone. Cancer Cell. 3:537–542. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Zhang S, Gao X, Xue, X, et al: The effect of baicalein on the expression of SATB1 in MDA-MB-231 cells. Chinese-German J Clin Oncol. 13:503–508. 2014.

43 

Philip S, Bulbule A and Kundu GC: Matrix metalloproteinase-2: Mechanism and regulation of NF-kappa B-mediated activation and its role in cell motility and ECM-invasion. Glycoconj J. 21:429–241. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE and Price JE: Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res. 11:7490–7498. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Mukhopadhyay A, Banerjee S, Stafford LJ, Xia C, Liu M and Aggarwal BB: Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene. 21:8852–8861. 2002. View Article : Google Scholar : PubMed/NCBI

46 

Parkin DM and Fernández LM: Use of statistics to assess the global burden of breast cancer. Breast J. 12(Suppl 1): S70–S80. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Wang S, Liu Q, Zhang Y, Liu K, Yu P, Liu K, Luan J, Duan H, Lu Z, Wang F, et al: Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action. Mol Cancer. 8:812009. View Article : Google Scholar : PubMed/NCBI

48 

Hatcher H, Planalp R, Cho J, Torti FM and Torti SV: Curcumin: From ancient medicine to current clinical trials. Cell Mol Life Sci. 65:1631–1652. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Motoo Y and Sawabu N: Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines. Cancer Lett. 86:91–95. 1994. View Article : Google Scholar : PubMed/NCBI

50 

Ikemoto S, Sugimura K, Yoshida N, Yasumoto R, Wada S, Yamamoto K and Kishimoto T: Antitumor effects of Scutellariae radix and its components baicalein, baicalin and wogonin on bladder cancer cell lines. Urology. 55:951–955. 2000. View Article : Google Scholar : PubMed/NCBI

51 

Ye F, Wu J, Dunn T, Yi J, Tong XD and Zhang D: Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. Cancer Lett. 211:39–46. 2004. View Article : Google Scholar : PubMed/NCBI

52 

Yu J, Liu H, Lei J, Tan W, Hu X and Zou G: Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents. Phytother Res. 21:817–822. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yan WJ, Ma XC, Gao XY, Xue XH and Zhang SQ: Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis (Review). Mol Clin Oncol 4: 472-476, 2016.
APA
Yan, W., Ma, X., Gao, X., Xue, X., & Zhang, S. (2016). Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis (Review). Molecular and Clinical Oncology, 4, 472-476. https://doi.org/10.3892/mco.2016.750
MLA
Yan, W., Ma, X., Gao, X., Xue, X., Zhang, S."Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis (Review)". Molecular and Clinical Oncology 4.4 (2016): 472-476.
Chicago
Yan, W., Ma, X., Gao, X., Xue, X., Zhang, S."Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis (Review)". Molecular and Clinical Oncology 4, no. 4 (2016): 472-476. https://doi.org/10.3892/mco.2016.750
Copy and paste a formatted citation
x
Spandidos Publications style
Yan WJ, Ma XC, Gao XY, Xue XH and Zhang SQ: Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis (Review). Mol Clin Oncol 4: 472-476, 2016.
APA
Yan, W., Ma, X., Gao, X., Xue, X., & Zhang, S. (2016). Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis (Review). Molecular and Clinical Oncology, 4, 472-476. https://doi.org/10.3892/mco.2016.750
MLA
Yan, W., Ma, X., Gao, X., Xue, X., Zhang, S."Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis (Review)". Molecular and Clinical Oncology 4.4 (2016): 472-476.
Chicago
Yan, W., Ma, X., Gao, X., Xue, X., Zhang, S."Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis (Review)". Molecular and Clinical Oncology 4, no. 4 (2016): 472-476. https://doi.org/10.3892/mco.2016.750
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