Polymorphous low‑grade adenocarcinoma of the epiglottis: A case report
- Authors:
- Noppadol Larbcharoensub
- Suda Sanpaphant
- Patamintita Witoonpanich
- Lojana Tuntiyatorn
- Jumroon Tungkeeratichai
- Wichit Cheewaruangroj
View Affiliations
Affiliations: Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand, Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand, Department of Otolaryngology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
- Published online on: February 16, 2016 https://doi.org/10.3892/mco.2016.780
-
Pages:
779-782
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
Polymorphous low‑grade adenocarcinoma is an uncommon malignant tumor derived from the terminal duct cells of the salivary glands. The present study described a rare case of polymorphous low‑grade adenocarcinoma, T2N0M0 stage 2, in a 65‑year‑old man, who presented with a sore throat and painful dysphagia. Computed tomography revealed an infiltrative heterogenous enhancing mass involving the left aryepiglottic fold. He underwent a tumor removal with frozen section for evaluating the surgical margin. Subsequent supraglottic laryngectomy was performed. Polymorphous low‑grade adenocarcinoma was diagnosed histologically, characterized by cytologic uniformly, morphologic diversity and an infiltrative growth pattern. Epiglottic cartilaginous invasion by the tumor is demonstrated. Clinical, radiological, endoscopic and pathological features with briefly reviewed relevant literatures are discussed. This is the first reported description in the literature, to the best of our knowledge, of an epiglottic polymorphous low‑grade adenocarcinoma receiving successful supraglottic laryngectomy with 7 year disease free survival.
View References
|
1
|
Lhuna MA and Wenig BM: World Health
Organization Classification of Tumours of the Salivary glands:
Polymorphous low-grade adenocarcinoma. Pathology and Genetics of
Head and Neck Tumours. Barnes L, Eveson JW, Reichart P and
Sidransky D: IARC Press. (Lyon). 223–224. 2005.
|
|
2
|
Seifert G: Histological typing of salivary
gland tumours (2nd). Springer-Verlag Berlin Heidelberg. New York:
22–23. 1991.
|
|
3
|
Ellis GL and Auclair PL: Polymorphous
low-grade adenocarcinoma. Tumors of the salivary glands (3rd).
Armed Forces Institute of Pathology. (Washington, DC). 216–228.
1996.
|
|
4
|
Takagi S, Tsunetomi K, Tsuda K, Mizokami
H, Ootani S and Shin T: A Case of Polymorphous Low-Grade
Adenocarcinoma (PLGA) of the Larynx. Larynx Japan. 10:136–139.
1998. View Article : Google Scholar
|
|
5
|
Jafarian AH, Khazaeni K, Rahpeyma A and
Khajehahmadi S: Polymorphous low-grade adenocarcinoma of the
larynx: A rare case report. Arch Iran Med. 16:560–562.
2013.PubMed/NCBI
|
|
6
|
Edwards PC, Bhuiya T and Kelsch RD:
Assessment of p63 expression in the salivary gland neoplasms
adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma and
basal cell and canalicular adenomas. Oral Surg Oral Med Oral Pathol
Oral Radiol Endod. 97:613–619. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Olusanya AA, Akadiri OA, Akinmoladun VI
and Adeyemi BF: Polymorphous low grade adenocarcinoma: Literature
review and report of lower lip lesion with suspected lung
metastasis. J Maxillofac Oral Surg. 10:60–63. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Eveson JW and Nagao T: Diseases of the
salivary glands. Surgical pathology of the head and neck. Barnes L:
(3rd). Informa Healthcare. (New York). 557–561. 2008.
|
|
9
|
Mino M, Pilch BZ and Faquin WC: Expression
of KIT (CD117) in neoplasms of the head and neck: An ancillary
marker for adenoid cystic carcinoma. Mod Pathol. 16:1224–1231.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
de Kerviler E, Bely N, Laccourreye O,
Clément O, Halimi P and Frija G: The aryepiglottic fold as a rare
location of adenoid cystic carcinoma. AJNR Am J Neuroradiol.
16:1375–1377. 1995.PubMed/NCBI
|
|
11
|
Darling MR, Schneider JW and Phillips VM:
Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma:
A review and comparison of immunohistochemical markers. Oral Oncol.
38:641–645. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Woo VL, Bhuiya T and Kelsch R: Assessment
of CD43 expression in adenoid cystic carcinomas, polymorphous
low-grade adenocarcinomas and monomorphic adenomas. Oral Surg Oral
Med Oral Pathol Oral Radiol Endod. 102:495–500. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Epivatianos A, Poulopoulos A,
Dimitrakopoulos I, Andreadis D, Nomikos A, Vlahou S, Papazoglou G
and Barbatis C: Application of alpha-smooth muscle actin and c-kit
in the differential diagnosis of adenoid cystic carcinoma from
polymorphous low-grade adenocarcinoma. Oral Oncol. 43:67–76. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Baptista PM, Garcia-Tapia R and Vazquez
JJ: Pleomorphic adenoma of the epiglottis. J Otolaryngol.
21:355–357. 1992.PubMed/NCBI
|
|
15
|
Pelkey TJ and Mills SE: Histologic
transformation of polymorphous low-grade adenocarcinoma of salivary
gland. Am J Clin Pathol. 111:785–791. 1999. View Article : Google Scholar : PubMed/NCBI
|
