Fibroepithelioma of Pinkus: Solitary tumor or sign of a complex gastrointestinal syndrome

Longo,Caterina; Pellacani,Giovanni; Tomasi,Aldo; Mandel,Victor  Desmond; Ponti,Giovanni

doi:10.3892/mco.2016.794

Fibroepithelioma of Pinkus: Solitary tumor or sign of a complex gastrointestinal syndrome

Authors:
- Caterina Longo
- Giovanni Pellacani
- Aldo Tomasi
- Victor Desmond Mandel
- Giovanni Ponti
View Affiliations

Affiliations: Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova‑IRCCS, I‑42123 Reggio Emilia, Italy, Department of Dermatology, University of Modena and Reggio Emilia, I‑41100 Modena, Italy, Department of Clinical and Diagnostic Medicine and Public Health, University of Modena and Reggio Emilia, I‑41100 Modena, Italy
Published online on: February 26, 2016 https://doi.org/10.3892/mco.2016.794
Pages: 797-800

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Fibroepithelioma of Pinkus (FEP), which is considered to be an uncommon variant of basal cell carcinoma, has been described in association with other systemic diseases. However, no specific studies are currently available on this subject. The aim of our study was to evaluate the clinical and morphological characteristics of FEP and investigate whether this rare tumor is a single entity or seen in the context of a more complex syndrome. We retrospectively analyzed 49 cases of FEP diagnosed and excised in a single academic institution from 1995 to 2011. The tumors were mainly located on the trunk (77.55%), followed by the lower extremities (12.20%) and the head and neck (10.20%). In 9 of the 49 cases (18%), FEP was associated with gastrointestinal tumors. The abovementioned cases are presented in an attempt to make clinicians more aware of a possible association between FEP and gastrointestinal cancer. Although a possible underlying common genetic background between FEP and gastrointestinal tumors was not provided, our study suggests that patients with FEP should be screened for the occurrence of gastrointestinal tumors.

View Figures

View References

1	Pinkus H: Premalignant fibroepithelial tumors of skin. AMA Arch Dermatol Syphilol. 67:598–615. 1953. View Article : Google Scholar
2	Bowen AR and LeBoit PE: Fibroepithelioma of Pinkus is a fenestrated trichoblastoma. Am J Dermatopathol. 27:149–154. 2005. View Article : Google Scholar : PubMed/NCBI
3	Sellheyer K, Nelson P and Kutzner H: Fibroepithelioma of Pinkus is a true basal cell carcinoma developing in association with a newly identified tumour-specific type of epidermal hyperplasia. Br J Dermatol. 166:88–97. 2012. View Article : Google Scholar : PubMed/NCBI
4	Longo C, Soyer HP, Pepe P, Casari A, Wurm EM, Guitera P and Pellacani G: In vivo confocal microscopic pattern of fibroepithelioma of Pinkus. Arch Dermatol. 148:5562012. View Article : Google Scholar : PubMed/NCBI
5	Zalaudek I, Ferrara G, Broganelli P, Moscarella E, Mordente I, Giacomel J and Argenziano G: Dermoscopy patterns of fibroepithelioma of Pinkus. Arch Dermatol. 142:1318–1322. 2006. View Article : Google Scholar : PubMed/NCBI
6	Katona TM, Ravis SM, Perkins SM, Moores WB and Billings SD: Expression of androgen receptor by fibroepithelioma of Pinkus: Evidence supporting classification as a basal cell carcinoma variant? Am J Dermatopathol. 29:7–12. 2007. View Article : Google Scholar : PubMed/NCBI
7	Warner TF, Burgess H and Mohs FE: Extramammary Paget's disease in fibroepithelioma of Pinkus. J Cutan Pathol. 9:340–344. 1982. View Article : Google Scholar : PubMed/NCBI
8	Bryant J: Fibroepithelioma of Pinkus overlying breast cancer. Arch Dermatol. 121:3101985. View Article : Google Scholar : PubMed/NCBI
9	Sandbank M and Baschan D: Multiple trichoepitelioma and breast carcinoma. Simultaneous appearance of epithelioma adenoides cysticum and infiltrating lobular carcinoma of the breast. Arch Dermatol. 114:12301978. View Article : Google Scholar : PubMed/NCBI
10	Gorlin RJ and Goltz RW: Multiple nevoid basal-cell epithelioma, jaw cysts and bifid rib. A syndrome. N Engl J Med. 262:908–912. 1960. View Article : Google Scholar : PubMed/NCBI
11	Prodinger PM, Sarbia M, Massmann J, Straka C, Meyer G and Steinlein OK: Gorlin syndrome associated with small bowel carcinoma and mesenchymal proliferation of the gastrointestinal tract: Case report and review of literature. BMC Cancer. 10:3602010. View Article : Google Scholar : PubMed/NCBI
12	Ponti G, Pellacani G, Seidenari S, Pollio A, Muscatello U and Tomasi A: Cancer-associated genodermatoses: Skin neoplasms as clues to hereditary tumor syndromes. Crit Rev Oncol Hematol. 85:239–256. 2013. View Article : Google Scholar : PubMed/NCBI
13	Saldanha G, Fletcher A and Slater DN: Basal cell carcinoma: A dermatopathological and molecular biological update. Br J Dermatol. 148:195–202. 2003. View Article : Google Scholar : PubMed/NCBI
14	Sidhu GS, Chandra P and Cassai ND: Merkel cells, normal and neoplastic: An update. Ultrastruct Pathol. 29:287–294. 2005. View Article : Google Scholar : PubMed/NCBI
15	Stanich PP, Owens VL, Sweetser S, Khambatta S, Smyrk TC, Richardson RL, Goetz MP and Patnaik MM: Colonic polyposis and neoplasia in Cowden syndrome. Mayo Clin Proc. 86:489–492. 2011. View Article : Google Scholar : PubMed/NCBI