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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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Review

Cardiotoxicity associated with targeted cancer therapies (Review)

  • Authors:
    • Zi Chen
    • Di Ai
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Pathology, Baylor Scott and White Memorial Hospital, Texas A&M Health Science Center, Temple, TX 76508, USA
  • Pages: 675-681
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    Published online on: March 3, 2016
       https://doi.org/10.3892/mco.2016.800
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Abstract

Compared with traditional chemotherapy, targeted cancer therapy is a novel strategy in which key molecules in signaling pathways involved in carcinogenesis and tumor spread are inhibited. Targeted cancer therapy has fewer adverse effects on normal cells and is considered to be the future of chemotherapy. However, targeted cancer therapy‑induced cardiovascular toxicities are occasionally critical issues in patients who receive novel anticancer agents, such as trastuzumab, bevacizumab, sunitinib and imatinib. The aim of this review was to discuss these most commonly used drugs and associated incidence of cardiotoxicities, including left ventricular dysfunction, heart failure, hypertension and thromboembolic events, as well as summarize their respective molecular mechanisms of cardiovascular adverse effects.
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1 

DeVita VT Jr and Chu E: A history of cancer chemotherapy. Cancer Res. 68:8643–8653. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Sawyers C: Targeted cancer therapy. Nature. 18:294–297. 2004. View Article : Google Scholar

3 

Manning G, Whyte DB, Martinez R, Hunter T and Sudarsanam S: The protein kinase complement of the human genome. Science. 298:1912–1934. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Prenzel N, Fischer OM, Steit S, Hart S and Ullrich A: The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocr Relat Cancer. 8:11–31. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Slichenmyer WJ and Fry DW: Anticancer therapy targeting the erbB family of receptor tyrosine kinases. Semin Oncol. 28(5 Suppl 16): 67–79. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Smith LA, Cornelius VR, Plummer CJ, Levitt G, Verrill M, Canney P and Jones A: Cardotoxicity of anthracycline agents for the treatment of cancer: Systematic review and meta-analysis of randomized controlled trails. BMC Cancer. 10:3372010. View Article : Google Scholar : PubMed/NCBI

7 

van Dalen EC, Michiels EM, Caron HN and Kremer LC: Different anthracycline derivates for reducing cardiotoxicity in cancer patients. Cochrane Database Syst Rev. CDOO50062010.

8 

Ewer MS and Ewer SM: Cardiotoxicity of anticancer treatments: What the cardiologist needs to know. Nat Rev Cariol. 7:564–575. 2010. View Article : Google Scholar

9 

Billingham ME, Mason JW, Bristow MR and Daniels JR: Anthracycline cardiomyopathy monitored by morphologic changes. Cancer Treat Rep. 62:865–872. 1978.PubMed/NCBI

10 

Bristow MR, Thompson PD, Martin RP, Mason JW, Billingham ME and Harrison DC: Early anthracyline cardiotoxicity. Am J Med. 65:823–832. 1978. View Article : Google Scholar : PubMed/NCBI

11 

Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A and McGuire WL: Human breast cancer: Correlation of relapse and survival with amplification for the HER-2/new oncogene. Science. 235:177–182. 1987. View Article : Google Scholar : PubMed/NCBI

12 

Schuell B, Gruenberger T, Scheithauer W, Zielinski Ch and Wrba F: HER 2/new protein expression in colorectal cancer. BMC Cancer. 6:1232006. View Article : Google Scholar : PubMed/NCBI

13 

Latif Z, Watters AD, Bartlett JM, Underwood MA and Aitchison M: Gene amplification and overexpression of HER2 in renal cell carcinoma. BJU Int. 89:5–9. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Jelovac D and Emens LA: HER2-directed therapy for metastatic breast cancer. Oncology (Williston Park). 27:166–175. 2013.PubMed/NCBI

15 

Cardinale D, Colombo A, Torrisi R, Sandri MT, Civelli M, Salvatici M, Lamantia G, Colombo N, Cortinovis S and Dessanai MA: Trastuzumab-induced cardiotoxicity: Clinical and prognostic implications of troponin I evaluation. J Clin Oncol. 28:3910–3916. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Chu TF, Rupnick MA, Kerkela R, Dallabrida SM, Zurakowski D, Nguyen L, Woulfe K, Pravda E, Cassiola F and Desai J: Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet. 370:2011–2019. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Shaikh AY and Shih JA: Chemotherapy-induced cardiotoxicity. Curr Heart Fail Rep. 9:117–27. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Seidman A, Hudis C, Pierri MK, Shak S, Paton V, Ashby M, Murphy M, Stewart SJ and Keefe D: Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol. 20:1215–1221. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, Fleming T, Eiermann W, Wolter J and Pegram M: Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 344:783–92. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Guarneri V, Lenihan DJ, Velaro V, Durand JB, Broglio K, Hess KR, Michaud LB, Gonzalez-Angulo AM, Hortobagyi GN and Esteva FJ: Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: The M.D. Anderson cancer center experience. J Clin Oncol. 24:4107–4115. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Ewer MS, Vooletich MT, Durand JB, Wood ML, Davis JR, Valero V and Lenihan DJ: Reversibility of trastuzumab-related cardiotoxicity: New insights based on clinical course and response to medical treatment. J Clin Oncol. 23:7820–7826. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Halyard MY, Pisansky TM, Dueck AC, Suman V, Pierce L, Solin L, Marks L, Davidson N, Martino S and Kaufman P: Radiotherapy and adjuvant trastuzumab in operable breast cancer: Tolerability and adverse event data from the NCCTG phase III trial N9831. J Clin Oncol. 27:2638–2644. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Garratt AN, Ozcelik C and Birchmeier C: ErbB2 pathways in heart and neural diseases. Trends Cardiovasc Med. 13:80–86. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Negro A, Brar BK and Lee KF: Essential roles of Her2/erbB2 in cardiac development and function. Recent Prog Horm Res. 59:1–12. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Crone SA, Zhao YY, Fan L, Gu Y, Minamisawa S, Liu Y, Peterson KL, Chen J, Kahn R and Condorelli G: ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med. 8:459–465. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Ozcelik C, Erdmann B, Pilz B, Wettschureck N, Britsch S, Hübner N, Chien KR, Birchmeier C and Garratt AN: Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Pro Natl Acad Sci USA. 99:8880–8885. 2002. View Article : Google Scholar

27 

Burris HA III, Hurwitz HI, Dees EC, Dowlati A, Blackwell KL, O'Neil B, Marcom PK, Ellis MJ, Overmoyer B, Jones SF, et al: Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J Clin Oncol. 23:5305–5313. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Geyer CE, Forster J, Lindquist D, Chan S, Romieu CG, Pienkowski T, Jaqiello-Gruszfeld A, Crown J, Chan A and Kaufman B: Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med. 355:2733–2743. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Gianni L, Lladó A, Bianchi G, Cortes J, Kellokumpu-Lehtinen PL, Cameron DA, Miles D, Salvagni S, Wardley A, Goeminne JC, et al: Open-label, phase II, multicenter, randomized study of the efficacy and safety of two dose levels of peruzumab, a human epidermal growth factor receptor 2 dimerization inhibitor, in patients with human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol. 28:1131–1137. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Perez EA, Koehler M, Byrne J, Preston AJ, Rappold E and Ewer MS: Cardiac safety of lapatinib: Pooled analysis of 3689 patients enrolled in clinical trials. Mayo Clin Proc. 83:679–686. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Fedele C, Riccio G, Malara AE, D'Alessio G and De Lorenzo C: Mechanisms of cardiotoxicity associated with ErbB2 inhibitors. Breast Cancer Res Treat. 134:595–602. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Clynes RA, Towers TL, Presta LG and Ravetch JV: Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med. 6:443–446. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Gennari R, Menard S, Fagnoni F, Ponchio L, Scelsi M, Tagliabue E, Castiglioni F, Villani L, Magalotti C and Gibelli N: Pilot study of the mechanism of action of preoperative trastuzumab in patients with primary operable breast tumors overexpressing HERS2. Clin Cancer Res. 10:5650–5655. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Van Cutsem E, Lambrechts D, Prenen H, Jain RK and Carmeliet P: Lessons from the adjuvant bevacizumab trial on colon cancer: What next? J Clin Oncol. 29:1–4. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Jardim DL, de Gagliato DM, Ribeiro KB, Shimada AK and Katz A: Bevacizumab as first-line therapy in advanced non-small-cell-lung cancer: A Brazillian center experience. Drugs R D. 12:207–216. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Rini BI: Vascular endothelial growth factor-targeted therapy in renal cell carcinoma: Current status and future directions. Clin Cancer Res. 13:1098–1106. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Scappacticci FA, Skillings JR, Holden SN, Gerber HP, Miller K, Kabbinavar F, Bergsland E, Ngai J, Kolmangren E, Wang J and Hurwitz H: Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J Natl Cancer Inst. 99:1232–1239. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Hurwitz HI, Fehrenbacher L, Hainsworth JD, Heim W, Berlin J, Holmgren E, Hambleton J, Novotny WF and Kabbinavar F: Bevacizumab in combination with fluorouracil and leucovorin: An active regimen for first-line metastatic colorectal cancer. J Clin Oncol. 23:3502–3508. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Miller KD, Chap LI, Holmes FA, Cobleigh MA, Marcom PK, Fehrenbacher L, Dickler M, Overmoyer BA, Reimann JD and Sing AP: Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol. 23:792–799. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Johnson DH, Fehrenbacher L, Novotny WF, Herbst RS, Nemunaitis JJ, Jablons DM, Langer CJ, DeVore RF III, Gaudreault J, Damico LA, et al: Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-lung cancer. J Clin Oncol. 22:2184–2191. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Hurwitz H and Saini S: Bevacizumab in the treatment of metastatic colorectal cancer: Safety profile and management of adverse events. Semin Oncol. 33(5 Suppl 10): S26–S34. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S and Holmgren E: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 350:2335–2342. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Pande A, Lombardo J, Spangenthal E and Javle M: Hypertension secondary to anti-angiogenic therapy: Experience with bevacizumab. Anticancer Res. 27:3465–3470. 2007.PubMed/NCBI

44 

Yeh ET, Tong AT, Lenihan DJ, Yusuf SW, Swafford J, Champion C, Durand JB, Gibbs H, Zafarmand AA and Ewer MS: Cardiovascular complications of cancer therapy: Diagnosis, pathogenesis and management. Circulation. 109:3122–3131. 2004. View Article : Google Scholar : PubMed/NCBI

45 

D'Adamo DR, Anderson SE, Albritton K, Yamada J, Riedel E, Scheu K, Schwartz GK, Chen H and Maki RG: Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas. J Clin Oncol. 23:7135–7142. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Karp JE, Gojo I, Pili R, Gocke CD, Greer J, Guo C, Qian D, Morris L, Tidwell M and Chen H: Targeting vascular endothelial growth factor for relapsed and refractory adult acute myelogenous leukemias: Therapy with sequential 1-beta-d-arabinofuranosylcytosine, mitoxantrone, and bevacizumab. Clin Cancer Res. 10:3577–3585. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Nalluri SR, Chu D, Keresztes R, Zhu X and Wu S: Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: A meta-analysis. JAMA. 300:2277–2285. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Laitinen M, Zachary I, Breier G, Pakkanen T, Häkinen T, Luoma J, Abedi H, Risau W, Soma M, Laakso M, et al: VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries. Hum Gene Ther. 8:1737–1744. 1997. View Article : Google Scholar : PubMed/NCBI

49 

Levy BI, Ambrosio G, Pries AR and Struijker-Boudier HA: Microcirculation in hypertension: A new target for treatment? Circulation. 104:735–740. 2001. View Article : Google Scholar : PubMed/NCBI

50 

Hesser BA, Liang XH, Camenisch G, Yang S, Lewin DA, Scheller R, Ferrara N and Gerber HP: Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells. Blood. 104:149–158. 2004. View Article : Google Scholar : PubMed/NCBI

51 

Kuenen BC, Levi M, Meijers JC, Kakkar AK, van Hinsbergh VW, Kostense PJ, Pinedo HM and Hoekman K: Analysis of coagulation cascade and endothelial cell activation during inhibition of vascular endothelial growth factor/vascular endothelial growth factor receptor pathway in cancer patients. Arterioscler Thromb Vasc Biol. 22:1500–1505. 2002. View Article : Google Scholar : PubMed/NCBI

52 

Whittle BJ, Moncada S and Vane JR: Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species. Prostaglandins. 16:373–388. 1978. View Article : Google Scholar : PubMed/NCBI

53 

Izumiya Y, Shiojima I, Sato K, Sawyer DB, Colucci WS and Walsh K: Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload. Hypertension. 47:887–893. 2006. View Article : Google Scholar : PubMed/NCBI

54 

Cheng H and Force T: Why do kinase inhibitors cause cardiotoxicity and what can be done about it? Prog Cariovasc Dis. 53:114–120. 2010. View Article : Google Scholar

55 

Cheng H and Force T: Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics. Circ Res. 106:21–34. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Kerkela R, Woulfe KC, Durand JB, Vagnozzi R, Kramer D, Chu TF, Beahm C, Chen MH and Force T: Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase. Clin Transl Sci. 2:15–25. 2009. View Article : Google Scholar : PubMed/NCBI

57 

Kerkela R, Grazette L, Yacobi R, Illiescu C, Patten R, Beahm C, Walters B, Shevtsov S, Pesant S and Clubb FJ: Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med. 12:908–16. 2006. View Article : Google Scholar : PubMed/NCBI

58 

Talpaz M, Shah NP, Kantarjian H, Donato N, Nicoll J, Paquette R, Cortes J, O'Brien S, Nicaise C and Bleickardt E: Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med. 354:2531–2541. 2006. View Article : Google Scholar : PubMed/NCBI

59 

Deming PB, Schafer ZT, Tashker JS, Potts MB, Deshmukh M and Kornbluth S: Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release. Mol Cell Biol. 24:10289–10299. 2004. View Article : Google Scholar : PubMed/NCBI

60 

Beininger M, Buchdunger E and Druker BJ: The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood. 105:2640–2653. 2005. View Article : Google Scholar : PubMed/NCBI

61 

Cohen MH, Williams G, Johnson JR, Duan J, Gobburu J, Rahman A, Benson K, Leighton J, Kim SK and Wood R: Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia. Clin Cancer Res. 8:935–942. 2002.PubMed/NCBI

62 

Atallah E, Durand JB, Kantarjian H and Cortes J: Congestive heart failure is a rare event in patients receiving imatinib therapy. Blood. 110:1233–1237. 2007. View Article : Google Scholar : PubMed/NCBI

63 

Hatfield A, Owen S and Pilot PR: In reply to ‘Cardiotoxicity of the cancer therapeutic agent imatinib mesylate’. Nat Med. 13:13; author reply 15–16. 2007. View Article : Google Scholar

64 

Rosti G, Martinelli G and Baccarani M: In reply to ‘Cardiotoxicity of the cancer therapeutic agent imatinib mesylate’. Nat Med. 13:15; author reply 15–16. 2007. View Article : Google Scholar

65 

Gambacorti-Passerini C, Tornaghi L, Franceschino A, Piazza R, Corneo G and Pogliani E: In reply to ‘Cardiotoxicity of the cancer therapeutic agent imatinib mesylate’. Nat Med. 13:13–14; author reply 15–16. 2007. View Article : Google Scholar : PubMed/NCBI

66 

Atallah E, Kantarjian H and Cortes J: In reply to ‘Cardiotoxicity of the cancer therapeutic agent imatinib mesylate’. Nat Med. 13:14; author reply 15–16. 2007. View Article : Google Scholar

67 

Fernández A, Sanguino A, Peng Z, Crespo A, Ozturk E, Zhang X, Wang S, Bornmann W and Lopez-Berestein G: Rational drug redesign to overcome drug resistance in cancer therapy: Imatinib moving target. Cancer Res. 67:4028–4033. 2007. View Article : Google Scholar : PubMed/NCBI

68 

Demetri GB: Structural reengineering of imatinib to decrease cardiac risk in cancer therapy. J Clin Invest. 117:3650–3653. 2007. View Article : Google Scholar : PubMed/NCBI

69 

Bearzi C, Rota M, Hosoda T, Tillmanns J, Nascimbene A, De Angelis A, Yasuzawa-Amano S, Trofimova I, Siggins RW and Lecapitaine N: Human cardiac stem cells. Proc Natl Acad Sci USA. 104:14068–14073. 2007. View Article : Google Scholar : PubMed/NCBI

70 

Ghoreschi K, Laurence A and O'Shea JJ: Selectivity and therapeutic inhibition of kinases: To be or not to be? Nat Immunol. 10:356–360. 2009. View Article : Google Scholar : PubMed/NCBI

71 

U.S. Food Drug Administration FDA approves new treatment for gastrointestinal and kidney cancer. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2006/ucm108583.htmAccessed. January 26–2006

72 

Young E, Miele L, Tucker KB, Huang M, Wells J and Gu JW: SU11248, a selective tyrosine kinases inhibitor suppresses breast tumor angiogenesis and growth via targeting both tumor vasculature and breast cancer cells. Cancer Biol Ther. 10:703–711. 2010. View Article : Google Scholar : PubMed/NCBI

73 

Xin H, Zhang C, Herrmann A, Du Y, Figlin R and Yu H: Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cell. Cancer Res. 69:2506–2513. 2009. View Article : Google Scholar : PubMed/NCBI

74 

Pal SK, Figlin RA and Yu H: Deciphering the anticancer mechanisms of sunitinib. Cancer Biol Ther. 10:712–714. 2010. View Article : Google Scholar : PubMed/NCBI

75 

Telli ML, Witteles RM, Fisher GA and Srinivas S: Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate. Ann Oncol. 19:1613–1618. 2008. View Article : Google Scholar : PubMed/NCBI

76 

Motzer RJ, Hutson TE, Tomczk P, Michaelson MD, Bukowski RM, Rixe O, Oudard S, Negrier S, Szczylik C and Kim ST: Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 356:115–124. 2007. View Article : Google Scholar : PubMed/NCBI

77 

Demetri GD, van Oosterom AT, Garrett CR, Blackstein ME, Shah MH, Verweij J, McArthur G, Judson IR, Heinrich MC, Morgan JA, et al: Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomized controlled trial. Lancet. 368:1329–1338. 2006. View Article : Google Scholar : PubMed/NCBI

78 

Edelberg JM, Lee SH, Kaur M, Tang L, Feirt NM, McCabe S, Bramwell O, Wong SC and Hong MK: Platelet-derived growth factor-AB limits the extent of mycocardial infarction in a rat model: Feasibility of restoring impaired angiogenic capacity in the aging heart. Circulation. 105:608–613. 2002. View Article : Google Scholar : PubMed/NCBI

79 

Chintalgattu V, Ai D, Langley RR, Zhang J, Bankson JA, Shih TL, Reddy AK, Coombes KR, Daher IN, Pati S, et al: Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress. J Clin Invest. 120:472–484. 2010. View Article : Google Scholar : PubMed/NCBI

80 

Rini BI, Cohen DP, Lu DR, Chen I, Hariharan S, Gore ME, Figlin RA, Baum MS and Motzer RJ: Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst. 103:763–773. 2011. View Article : Google Scholar : PubMed/NCBI

81 

Fleisher LA, Fleischmann KE, Auerbach AD, Barnason SA, Beckman JA, Bozkurt B, Davila-Roman VG, Gerhard-Herman MD, Holly TA, Kane GC, Marine JE, Nelson MT, Spencer CC, Thompson A, Ting HH, Uretsky BF and Wijeysundera DN: American College of Cardiology; American Heart Association: 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. J Am Coll Cardiol. 64:e77–e137. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen Z and Ai D: Cardiotoxicity associated with targeted cancer therapies (Review). Mol Clin Oncol 4: 675-681, 2016.
APA
Chen, Z., & Ai, D. (2016). Cardiotoxicity associated with targeted cancer therapies (Review). Molecular and Clinical Oncology, 4, 675-681. https://doi.org/10.3892/mco.2016.800
MLA
Chen, Z., Ai, D."Cardiotoxicity associated with targeted cancer therapies (Review)". Molecular and Clinical Oncology 4.5 (2016): 675-681.
Chicago
Chen, Z., Ai, D."Cardiotoxicity associated with targeted cancer therapies (Review)". Molecular and Clinical Oncology 4, no. 5 (2016): 675-681. https://doi.org/10.3892/mco.2016.800
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Z and Ai D: Cardiotoxicity associated with targeted cancer therapies (Review). Mol Clin Oncol 4: 675-681, 2016.
APA
Chen, Z., & Ai, D. (2016). Cardiotoxicity associated with targeted cancer therapies (Review). Molecular and Clinical Oncology, 4, 675-681. https://doi.org/10.3892/mco.2016.800
MLA
Chen, Z., Ai, D."Cardiotoxicity associated with targeted cancer therapies (Review)". Molecular and Clinical Oncology 4.5 (2016): 675-681.
Chicago
Chen, Z., Ai, D."Cardiotoxicity associated with targeted cancer therapies (Review)". Molecular and Clinical Oncology 4, no. 5 (2016): 675-681. https://doi.org/10.3892/mco.2016.800
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