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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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May-2016 Volume 4 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Case Report Open Access

HER2‑positive double primary tumor of gastric and breast cancer occur synchronously in a patient: A case report

  • Authors:
    • Quchang Ouyang
    • Can Tian
    • Jianxiang Gao
    • Jin Huang
    • Hua Fu
    • Jinsong He
    • Jianbo Yang

  • View Affiliations / Copyright

    Affiliations: Oncology Division of Breast Cancer, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China, Shanghai Roche Pharmaceuticals, Pudong, Shanghai 201203, P.R. China, The Third Affiliated Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China, Department of Breast Surgery, The First Affiliated Hospital of Shenzhen University, The Second People's Hospital of Shenzhen, Shenzhen, Guangdong 518029, P.R. China
    Copyright: © Ouyang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 719-722
    |
    Published online on: March 9, 2016
       https://doi.org/10.3892/mco.2016.812
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Abstract

The simultaneous occurrence of primary gastric cancer and breast cancer is rare, and the positive expression of human epidermal growth factor receptor (HER)2 in double primary carcinoma of gastric and breast cancer remains to be reported. The present study presented a 46‑year‑old woman complaining of irregular acid reflux and stomach discomfort. The stomach cancer was diagnosed by esophagogastroduodenoscopy examination of the pathological biopsies in 2010. The patient underwent a radical gastrectomy for gastric cancer, and postoperative pathological examination revealed moderately‑poorly differentiated adenocarcinoma with HER2 positive expression. The tumor invaded into the entire thickness of the gastric wall and lymph nodes. The patient received five treatments of postoperative chemotherapy. In August 2011, the patient felt a lump in the right breast. Simple excision of the right breast mass was performed on September 2011, and postoperative pathological examination revealed the invasive ductal carcinoma of the right breast with HER2 amplification by fluorescent in situ hybridization assay. The patient was treated with postoperative chemotherapy and radiotherapy, and also Trastuzumab target therapy. The patient succumbed to aggressive disease progression in March 2012.
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Copy and paste a formatted citation
Spandidos Publications style
Ouyang Q, Tian C, Gao J, Huang J, Fu H, He J and Yang J: HER2‑positive double primary tumor of gastric and breast cancer occur synchronously in a patient: A case report. Mol Clin Oncol 4: 719-722, 2016.
APA
Ouyang, Q., Tian, C., Gao, J., Huang, J., Fu, H., He, J., & Yang, J. (2016). HER2‑positive double primary tumor of gastric and breast cancer occur synchronously in a patient: A case report. Molecular and Clinical Oncology, 4, 719-722. https://doi.org/10.3892/mco.2016.812
MLA
Ouyang, Q., Tian, C., Gao, J., Huang, J., Fu, H., He, J., Yang, J."HER2‑positive double primary tumor of gastric and breast cancer occur synchronously in a patient: A case report". Molecular and Clinical Oncology 4.5 (2016): 719-722.
Chicago
Ouyang, Q., Tian, C., Gao, J., Huang, J., Fu, H., He, J., Yang, J."HER2‑positive double primary tumor of gastric and breast cancer occur synchronously in a patient: A case report". Molecular and Clinical Oncology 4, no. 5 (2016): 719-722. https://doi.org/10.3892/mco.2016.812
Copy and paste a formatted citation
x
Spandidos Publications style
Ouyang Q, Tian C, Gao J, Huang J, Fu H, He J and Yang J: HER2‑positive double primary tumor of gastric and breast cancer occur synchronously in a patient: A case report. Mol Clin Oncol 4: 719-722, 2016.
APA
Ouyang, Q., Tian, C., Gao, J., Huang, J., Fu, H., He, J., & Yang, J. (2016). HER2‑positive double primary tumor of gastric and breast cancer occur synchronously in a patient: A case report. Molecular and Clinical Oncology, 4, 719-722. https://doi.org/10.3892/mco.2016.812
MLA
Ouyang, Q., Tian, C., Gao, J., Huang, J., Fu, H., He, J., Yang, J."HER2‑positive double primary tumor of gastric and breast cancer occur synchronously in a patient: A case report". Molecular and Clinical Oncology 4.5 (2016): 719-722.
Chicago
Ouyang, Q., Tian, C., Gao, J., Huang, J., Fu, H., He, J., Yang, J."HER2‑positive double primary tumor of gastric and breast cancer occur synchronously in a patient: A case report". Molecular and Clinical Oncology 4, no. 5 (2016): 719-722. https://doi.org/10.3892/mco.2016.812
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