Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
June-2016 Volume 4 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2016 Volume 4 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta‑analysis of 32 case‑control studies

  • Authors:
    • Ming‑Xing Zhang
    • Kai Liu
    • Fu‑Gang Wang
    • Xiao‑Wen Wen
    • Xi‑Lin Song
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, P.R. China
  • Pages: 1031-1038
    |
    Published online on: March 18, 2016
       https://doi.org/10.3892/mco.2016.824
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Previous studies suggested that RsaI/PstI and DraI polymorphisms on cytochrome P450 2E1 (CYP2E1) may be associated with susceptibility to gastric cancer (GC). However, this association remains ambiguous. A meta‑analysis of previously published studies was performed in an attempt to elucidate this association. The odds ratio and 95% confidence interval were used to assess the strength of the association. In the overall analyses of RsaI/PstI and DraI, no association was identified. In the subgroup analyses, RsaI/PstI was identified to increase the risk of GC in the smoking population. In addition, in the previous studies of interactions with other genes, RsaI/PstI was revealed to be associated with increased GC risks when glutathione S‑transferase‑µ‑1 or glutathione S‑transferase θ‑1 was null or DraI was homozygous wild‑type. However, these stratified analyses were lacking credibility due to the limitation of correlational study numbers. In conclusion, CYP2E1 polymorphisms revealed no association with the risk of GC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Karimi P, Islami F, Anandasabapathy S, Freedman ND and Kamangar F: Gastric cancer: Descriptive epidemiology, risk factors, screening and prevention. Cancer Epidemiol Biomarkers Prev. 23:700–713. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Yang L: Incidence and mortality of gastric cancer in China. World J Gastroenterol. 12:17–20. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Gianfagna F, De Feo E, van Duijn CM, Ricciardi G and Boccia S: A systematic review of meta-analyses on gene polymorphisms and gastric cancer risk. Curr Genomics. 9:361–374. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Hamilton JP and Meltzer SJ: A review of the genomics of gastric cancer. Clin Gastroenterol Hepatol. 4:416–425. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Milne AN, Carneiro F, O'Morain C and Offerhaus GJ: Nature meets nurture: Molecular genetics of gastric cancer. Hum Genet. 126:615–628. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Saeki N, Ono H, Sakamoto H and Yoshida T: Genetic factors related to gastric cancer susceptibility identified using a genome-wide association study. Cancer Sci. 104:1–8. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Yoshida T, Ono H, Kuchiba A, Saeki N and Sakamoto H: Genome-wide germline analyses on cancer susceptibility and GeMDBJ database: Gastric cancer as an example. Cancer Sci. 101:1582–1589. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Bellec G, Dréano Y, Lozach P, Ménez JF and Berthou F: Cytochrome P450 metabolic dealkylation of nine N-nitrosodialkylamines by human liver microsomes. Carcinogenesis. 17:2029–2034. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Ingelman-Sundberg M, Ronis MJ, Lindros KO, Eliasson E and Zhukov A: Ethanol-inducible cytochrome P4502E1: Regulation, enzymology and molecular biology. Alcohol Alcohol Suppl. 2:131–139. 1994.PubMed/NCBI

11 

Raucy JL, Kraner JC and Lasker JM: Bioactivation of halogenated hydrocarbons by cytochrome P4502E1. Crit Rev Toxicol. 23:1–20. 1993. View Article : Google Scholar : PubMed/NCBI

12 

La Vecchia C, D'Avanzo B, Airoldi L, Braga C and Decarli A: Nitrosamine intake and gastric cancer risk. Eur J Cancer Prev. 4:469–474. 1995. View Article : Google Scholar : PubMed/NCBI

13 

Agundez JA: Cytochrome P450 gene polymorphism and cancer. Curr Drug Metab. 5:211–224. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Uematsu F, Ikawa S, Kikuchi H, et al: Restriction fragment length polymorphism of the human CYP2E1 (cytochrome P450IIE1) gene and susceptibility to lung cancer: Possible relevance to low smoking exposure. Pharmacogenetics. 4:58–63. 1994. View Article : Google Scholar : PubMed/NCBI

15 

Hayashi S, Watanabe J and Kawajiri K: Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene. J Biochem. 110:559–565. 1991.PubMed/NCBI

16 

Uchimoto T, Itoga S, Nezu M, Sunaga M, Tomonaga T and Nomura F: Role of the genetic polymorphisms in the 5′-flanking region for transcriptional regulation of the human CYP2E1 gene. Alcohol Clin Exp Res. 31(Suppl 1): S36–S42. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Tang K, Li Y, Zhang Z, et al: The PstI/RsaI and DraI polymorphisms of CYP2E1 and head and neck cancer risk: A meta-analysis based on 21 case-control studies. BMC Cancer. 10:5752010. View Article : Google Scholar : PubMed/NCBI

18 

Agudo A, Sala N, Pera G, et al: No association between polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the risk of gastric adenocarcinoma in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev. 15:1043–1045. 2006. View Article : Google Scholar : PubMed/NCBI

19 

González A, Ramírez V, Cuenca P and Sierra R: Polymorphisms in detoxification genes CYP1A1, CYP2E1, GSTT1 and GSTM1 in gastric cancer susceptibility. Rev Biol Trop. 52:591–600. 2004.(In Spanish). PubMed/NCBI

20 

Boccia S, De Lauretis A, Gianfagna F, van Duijn CM and Ricciardi G: CYP2E1PstI/RsaI polymorphism and interaction with tobacco, alcohol and GSTs in gastric cancer susceptibility: A meta-analysis of the literature. Carcinogenesis. 28:101–106. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Cai L, Yu SZ and Zhan ZF: Cytochrome P450 2E1 genetic polymorphism and gastric cancer in Changle, Fujian Province. World J Gastroenterol. 7:792–795. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Gao C, Takezaki T, Wu J, et al: Interaction between cytochrome P-450 2E1 polymorphisms and environmental factors with risk of esophageal and stomach cancers in Chinese. Cancer Epidemiol Biomarkers Prev. 11:29–34. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Colombo J, Rossit AR, Caetano A, Borim AA, Wornrath D and Silva AE: GSTT1, GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population. World J Gastroenterol. 10:1240–1245. 2004.PubMed/NCBI

24 

Darazy M, Balbaa M, Mugharbil A, et al: CYP1A1, CYP2E1, and GSTM1 gene polymorphisms and susceptibility to colorectal and gastric cancer among Lebanese. Genet Test Mol Biomarkers. 15:423–429. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Ghoshal U, Tripathi S, Kumar S, et al: Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2 and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection. Gastric Cancer. 17:226–234. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Nan HM, Song YJ, Yun HY, Park JS and Kim H: Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. World J Gastroenterol. 11:3834–3841. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Feng J, Pan X, Yu J, et al: Functional PstI/RsaI polymorphism in CYP2E1 is associated with the development, progression and poor outcome of gastric cancer. PLoS One. 7:e444782012. View Article : Google Scholar : PubMed/NCBI

28 

Kato S, Onda M, Matsukura N, et al: Cytochrome P4502E1 (CYP2E1) genetic polymorphism in a case-control study of gastric cancer and liver disease. Pharmacogenetics. 5:S141–S144. 1995. View Article : Google Scholar : PubMed/NCBI

29 

Kato S, Onda M, Matsukura N, et al: Genetic polymorphisms of the cancer related gene and Helicobacter pylori infection in Japanese gastric cancer patients. An age and gender matched case-control study. Cancer. 77(Suppl 8): S1654–S1661. 1996. View Article : Google Scholar

30 

Kato S, Naito Z, Matsuda N, et al: Localization of cytochrome P4502E1 enzyme in normal and cancerous gastric mucosa and association with its genetic polymorphism in unoperated and remnant stomach. J Nippon Med Sch. 78:224–234. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Malakar M, Devi KR, Phukan RK, et al: CYP2E1 genetic polymorphism with dietary, tobacco, alcohol habits, H. pylori infection status and susceptibility to stomach cancer in Mizoram, India. Asian Pac J Cancer Prev. 15:8815–8822. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Malik MA, Upadhyay R, Mittal RD, Zargar SA, Modi DR and Mittal B: Role of xenobiotic-metabolizing enzyme gene polymorphisms and interactions with environmental factors in susceptibility to gastric cancer in Kashmir Valley. J Gastrointest Cancer. 40:26–32. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Wu MS, Chen CJ, Lin MT, et al: Genetic polymorphisms of cytochrome p450 2E1, glutathione S-transferase M1 and T1, and susceptibility to gastric carcinoma in Taiwan. Int J Colorectal Dis. 17:338–343. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Nishimoto IN, Hanaoka T, Sugimura H, et al: Cytochrome P450 2E1 polymorphism in gastric cancer in Brazil: Case control studies of Japanese Brazilians and non-Japanese Brazilians. Cancer Epidemiol Biomarkers Prev. 9:675–680. 2000.PubMed/NCBI

35 

Park GT, Lee OY, Kwon SJ, et al: Analysis of CYP2E1 polymorphism for the determination of genetic susceptibility to gastric cancer in Koreans. J Gastroenterol Hepatol. 18:1257–1263. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Suzuki S, Muroishi Y, Nakanishi I and Oda Y: Relationship between genetic polymorphisms of drug-metabolizing enzymes (CYP1A1, CYP2E1, GSTM1 and NAT2), drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer. J Gastroenterol. 39:220–230. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Tsukino H, Kuroda Y, Qiu D, Nakao H, Imai H and Katoh T: Effects of cytochrome P450 (CYP) 2A6 gene deletion and CYP2E1 genotypes on gastric adenocarcinoma. Int J Cancer. 100:425–428. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Li Z and Xu L: Relationship between cytochrome P450 2E1 gene polymorphism and gastric cancer susceptibility. J Pract Med. 3380–3381. 2007.

39 

Qian Y, Xu Y, Shen H, Yu R, Tan Y, Zhou L and Niu J: Relationship between CYP2E1, GSTT1 genetic polymorphisms and susceptibility to gastric cancer. China's primary health care. 18–20. 2001.

40 

Qian Y, Xu Y, Shen H, Zhou L, Yu R, Niu J and Tan Y: Relationship Between CYP2E1, GSTT1 Genetic Polymorphisms and Susceptibility to Gastric Cancer. Chin J Prev Control Chron Non Commun Dis. 107–109. 2003.

41 

Wang Y, Jiang Y and Sun W: Effects of genetic polymorphism of cytochrome P4502E1 on susceptibility to gastric cancer. Chin J Publ Health. 664–665. 2005.

42 

Yan S, Bai Z, Zhao J, Xie D and Wu J: Correlation between genetic polymorphisms of CYP2E1 RsaI and susceptibility of gastric cancer in Qinghai province. J Qinghai Med Coll. 34:7–14. 2013.

43 

Su Y, Zhenzhong B, Jian-xin Z, et al: Correlation between genetic polymorphisms of CYP2E1 Dra I and susceptibility of gastric cancer in Qinghai province. China Oncol. 23:273–278. 2013.

44 

Ye M, Liu J, Zhou X and Deng C: Association between CYE2E1 genotype and genetic susceptibility of gastric cancer. J Fourth Mil Med Univ. 2265–2267. 2002.

45 

Zhou J, Gao C, Takezaki T, Li Z, Wu J, Ding J, Liu Y, Li S, Hu X, Kai H and Tajima K: Interaction between polymorphisms in CYP2E1 Rsa I genotypes and lifestyle with risk of stomach cancer. J Oncol. 9:285–288. 2003.

46 

Higgins JP, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003. View Article : Google Scholar : PubMed/NCBI

47 

DerSimonian R and Laird N: Meta-analysis in clinical trials. Control Clin Trials. 7:177–188. 1986. View Article : Google Scholar : PubMed/NCBI

48 

Begg CB and Mazumdar M: Operating characteristics of a rank correlation test for publication bias. Biometrics. 50:1088–1101. 1994. View Article : Google Scholar : PubMed/NCBI

49 

Egger M, Smith Davey G, Schneider M and Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–634. 1997. View Article : Google Scholar : PubMed/NCBI

50 

Munafò MR, Clark TG and Flint J: Assessing publication bias in genetic association studies: Evidence from a recent meta-analysis. Psychiatry Res. 129:39–44. 2004. View Article : Google Scholar : PubMed/NCBI

51 

Zhuo W, Zhang L, Wang Y, Ling J, Zhu B and Chen Z: CYP2E1 RsaI/PstI polymorphism and gastric cancer susceptibility: Meta-analyses based on 24 case-control studies. PLoS One. 7:e482652012. View Article : Google Scholar : PubMed/NCBI

52 

Ruano-Ravina A, Pérez-Ríos M and Barros-Dios JM: Population-based versus hospital-based controls: Are they comparable? Gac Sanit. 22:609–613. 2008. View Article : Google Scholar : PubMed/NCBI

53 

Garte S, Gaspari L, Alexandrie AK, et al: Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarkers Prev. 10:1239–1248. 2001.PubMed/NCBI

54 

Neafsey P, Ginsberg G, Hattis D, Johns DO, Guyton KZ and Sonawane B: Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity. J Toxicol Environ Health B Crit Rev. 12:362–388. 2009. View Article : Google Scholar : PubMed/NCBI

55 

Stephens EA, Taylor JA, Kaplan N, et al: Ethnic variation in the CYP2E1 gene: Polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese. Pharmacogenetics. 4:185–192. 1994. View Article : Google Scholar : PubMed/NCBI

56 

Schmidt HM, Ha DM, Taylor EF, et al: Variation in human genetic polymorphisms, their association with Helicobacter pylori acquisition and gastric cancer in a multi-ethnic country. J Gastroenterol Hepatol. 26:1725–1732. 2011. View Article : Google Scholar : PubMed/NCBI

57 

Benowitz NL, Peng M and Jacob P III: Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism. Clin Pharmacol Ther. 74:468–474. 2003. View Article : Google Scholar : PubMed/NCBI

58 

Murata M, Takayama K, Choi BC and Pak AW: A nested case-control study on alcohol drinking, tobacco smoking, and cancer. Cancer Detect Prev. 20:557–565. 1996.PubMed/NCBI

59 

Masoudi M, Saadat I, Omidvari S and Saadat M: Genetic polymorphisms of GSTO2, GSTM1, and GSTT1 and risk of gastric cancer. Mol Biol Rep. 36:781–784. 2009. View Article : Google Scholar : PubMed/NCBI

60 

Wu X, Amos CI, Kemp BL, et al: Cytochrome P450 2E1 DraI polymorphisms in lung cancer in minority populations. Cancer Epidemiol Biomarkers Prev. 7:13–18. 1998.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang MX, Liu K, Wang FG, Wen XW and Song XL: Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta‑analysis of 32 case‑control studies. Mol Clin Oncol 4: 1031-1038, 2016.
APA
Zhang, M., Liu, K., Wang, F., Wen, X., & Song, X. (2016). Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta‑analysis of 32 case‑control studies. Molecular and Clinical Oncology, 4, 1031-1038. https://doi.org/10.3892/mco.2016.824
MLA
Zhang, M., Liu, K., Wang, F., Wen, X., Song, X."Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta‑analysis of 32 case‑control studies". Molecular and Clinical Oncology 4.6 (2016): 1031-1038.
Chicago
Zhang, M., Liu, K., Wang, F., Wen, X., Song, X."Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta‑analysis of 32 case‑control studies". Molecular and Clinical Oncology 4, no. 6 (2016): 1031-1038. https://doi.org/10.3892/mco.2016.824
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang MX, Liu K, Wang FG, Wen XW and Song XL: Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta‑analysis of 32 case‑control studies. Mol Clin Oncol 4: 1031-1038, 2016.
APA
Zhang, M., Liu, K., Wang, F., Wen, X., & Song, X. (2016). Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta‑analysis of 32 case‑control studies. Molecular and Clinical Oncology, 4, 1031-1038. https://doi.org/10.3892/mco.2016.824
MLA
Zhang, M., Liu, K., Wang, F., Wen, X., Song, X."Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta‑analysis of 32 case‑control studies". Molecular and Clinical Oncology 4.6 (2016): 1031-1038.
Chicago
Zhang, M., Liu, K., Wang, F., Wen, X., Song, X."Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta‑analysis of 32 case‑control studies". Molecular and Clinical Oncology 4, no. 6 (2016): 1031-1038. https://doi.org/10.3892/mco.2016.824
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team