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Molecular and Clinical Oncology
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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Connexin 43 expression is associated with poor survival in patients with esophageal squamous cell carcinoma

  • Authors:
    • Tatsuya Tanaka
    • Masahiro Kimura
    • Hideyuki Ishiguro
    • Kouji Mizoguchi
    • Hiromitsu Takeyama
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Nagoya University, Nagoya, Aichi 467‑8601, Japan
  • Pages: 989-993
    |
    Published online on: March 22, 2016
       https://doi.org/10.3892/mco.2016.828
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Abstract

Connexin 43 (Cx43) is an important gap junction protein in vertebrates, which has been reported to function as a tumor suppressor in a number of organs. However, the mechanism underlying the effect of Cx43 on tumor progression remains unknown, with only a limited number of studies reporting on the role of Cx43 in esophageal cancer. In the present study, Cx43 expression was analyzed by immunohistochemical staining and the associations between Cx43 expression and clinicopathological characteristics or prognosis were evaluated. Cx43 was expressed at a high frequency in patients with esophageal squamous cell carcinoma (ESCC). Of the 98 ESCC cases investigated, positivity for Cx43 was observed in 62 cases (63.26%). In patients with high Cx43 expression, the survival rates were significantly reduced compared with those in patients with low Cx43 expression. Moreover, the overexpression of Cx43, as measured by immunohistochemistry, was an independent prognostic indicator of ESCC. Thus, our data indicated that Cx43 may be a candidate molecular prognostic marker and molecular target for the development of an effective therapeutic intervention for patients with esophageal cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Tanaka T, Kimura M, Ishiguro H, Mizoguchi K and Takeyama H: Connexin 43 expression is associated with poor survival in patients with esophageal squamous cell carcinoma. Mol Clin Oncol 4: 989-993, 2016.
APA
Tanaka, T., Kimura, M., Ishiguro, H., Mizoguchi, K., & Takeyama, H. (2016). Connexin 43 expression is associated with poor survival in patients with esophageal squamous cell carcinoma. Molecular and Clinical Oncology, 4, 989-993. https://doi.org/10.3892/mco.2016.828
MLA
Tanaka, T., Kimura, M., Ishiguro, H., Mizoguchi, K., Takeyama, H."Connexin 43 expression is associated with poor survival in patients with esophageal squamous cell carcinoma". Molecular and Clinical Oncology 4.6 (2016): 989-993.
Chicago
Tanaka, T., Kimura, M., Ishiguro, H., Mizoguchi, K., Takeyama, H."Connexin 43 expression is associated with poor survival in patients with esophageal squamous cell carcinoma". Molecular and Clinical Oncology 4, no. 6 (2016): 989-993. https://doi.org/10.3892/mco.2016.828
Copy and paste a formatted citation
x
Spandidos Publications style
Tanaka T, Kimura M, Ishiguro H, Mizoguchi K and Takeyama H: Connexin 43 expression is associated with poor survival in patients with esophageal squamous cell carcinoma. Mol Clin Oncol 4: 989-993, 2016.
APA
Tanaka, T., Kimura, M., Ishiguro, H., Mizoguchi, K., & Takeyama, H. (2016). Connexin 43 expression is associated with poor survival in patients with esophageal squamous cell carcinoma. Molecular and Clinical Oncology, 4, 989-993. https://doi.org/10.3892/mco.2016.828
MLA
Tanaka, T., Kimura, M., Ishiguro, H., Mizoguchi, K., Takeyama, H."Connexin 43 expression is associated with poor survival in patients with esophageal squamous cell carcinoma". Molecular and Clinical Oncology 4.6 (2016): 989-993.
Chicago
Tanaka, T., Kimura, M., Ishiguro, H., Mizoguchi, K., Takeyama, H."Connexin 43 expression is associated with poor survival in patients with esophageal squamous cell carcinoma". Molecular and Clinical Oncology 4, no. 6 (2016): 989-993. https://doi.org/10.3892/mco.2016.828
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