Hepatic schwannoma: A case report and an updated 40-year review of the literature yielding 30 cases

Wan,Da‑Long; Zhai,Zheng‑Long; Ren,Kui‑Wu; Yang,Yun‑Chuan; Lin,Sheng‑Zhang; Zheng,Shu‑Sen

doi:10.3892/mco.2016.850

Hepatic schwannoma: A case report and an updated 40-year review of the literature yielding 30 cases

Authors:
- Da‑Long Wan
- Zheng‑Long Zhai
- Kui‑Wu Ren
- Yun‑Chuan Yang
- Sheng‑Zhang Lin
- Shu‑Sen Zheng
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Affiliations: Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang 310003, P.R. China, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang 310003, P.R. China
Published online on: April 6, 2016 https://doi.org/10.3892/mco.2016.850
Pages: 959-964

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Abstract

Hepatic schwannoma is a rare benign disease with a good prognosis. Early diagnosis is difficult due to the absence of specific clinical presentations and its rarity. The present study briefly described a 64‑year‑old female patient with hepatic schwannoma mimicking intrahepatic cholangiocarcinoma. Furthermore, the clinical data of 30 patients with hepatic schwannoma were also reviewed and analyzed. The mean age of the 30 patients was 51.7 years (range, 21-83 years) and ~2/3 were female. All patients in the benign group underwent surgical treatment and survived until the last follow-up, of whom 19 received complete resection and the remaining 1 underwent liver transplantation. However, in the malignant group, only three cases who underwent the surgical resection remained alive at last follow‑up. Another seven cases were succumbed to mortality, 4 cases of whom had deteriorated to have no operation opportunity by the time they saw a doctor, and among the remaining three cases with hepatectomy, 1 died of liver dysfunction at 21 days postoperatively, 2 succumbed to recurrences at 18 and 23 months postoperatively. In conclusion, hepatic schwannoma is a rare benign disease with a good prognosis. However, once the malignant transformation occurs, the prognosis is not satisfied. Complete resection is the mainstay for cure and liver transplantation is often necessary.

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