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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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June-2016 Volume 4 Issue 6

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Case Report

Hepatic schwannoma: A case report and an updated 40-year review of the literature yielding 30 cases

  • Authors:
    • Da‑Long Wan
    • Zheng‑Long Zhai
    • Kui‑Wu Ren
    • Yun‑Chuan Yang
    • Sheng‑Zhang Lin
    • Shu‑Sen Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang 310003, P.R. China, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang 310003, P.R. China
  • Pages: 959-964
    |
    Published online on: April 6, 2016
       https://doi.org/10.3892/mco.2016.850
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Abstract

Hepatic schwannoma is a rare benign disease with a good prognosis. Early diagnosis is difficult due to the absence of specific clinical presentations and its rarity. The present study briefly described a 64‑year‑old female patient with hepatic schwannoma mimicking intrahepatic cholangiocarcinoma. Furthermore, the clinical data of 30 patients with hepatic schwannoma were also reviewed and analyzed. The mean age of the 30 patients was 51.7 years (range, 21-83 years) and ~2/3 were female. All patients in the benign group underwent surgical treatment and survived until the last follow-up, of whom 19 received complete resection and the remaining 1 underwent liver transplantation. However, in the malignant group, only three cases who underwent the surgical resection remained alive at last follow‑up. Another seven cases were succumbed to mortality, 4 cases of whom had deteriorated to have no operation opportunity by the time they saw a doctor, and among the remaining three cases with hepatectomy, 1 died of liver dysfunction at 21 days postoperatively, 2 succumbed to recurrences at 18 and 23 months postoperatively. In conclusion, hepatic schwannoma is a rare benign disease with a good prognosis. However, once the malignant transformation occurs, the prognosis is not satisfied. Complete resection is the mainstay for cure and liver transplantation is often necessary.
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1 

Hytiroglou P, Linton P, Klion F, Schwartz M, Miller C and Thung SN: Benign schwannoma of the liver. Arch Pathol Lab Med. 117:216–218. 1993.PubMed/NCBI

2 

Ozkan EE, Guldur ME and Uzunkoy A: A Case report of benign schwannoma of the liver. Intern Med. 49:1533–1536. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Verocay J: Zur Kenntnis der ‘Neurofibrome. ’ Beitr Pathol Anat Allg Pathol. 48:1–69. 1910.(In German).

4 

Fletcher CD, Bridge JA, Hogendoorn PC and Mertens: World Health Organization classification of soft tissue and bone tumours. Lyon-IARC Press. 2013.

5 

Ota Y, Aso K, Watanabe K, Einama T, Imai K, Karasaki H, Sudo R, Tamaki Y, Okada M, Tokusashi Y, et al: Hepatic schwannoma: Imaging findings on CT, MRI and contrast-enhanced ultrasonography. World J Gastroenterol. 18:4967–4972. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Ortega-Candil A, Rodríguez-Rey C, Cabrera-Martín MN, García García-Esquinas M, Lapeña-Gutiérrez L and Carreras-Delgado JL: 18FDG PET/CT imaging of schwannoma mimicking colorectal cancer metastasis. Rev Esp Med Nucl Imagen Mol. 32:332–333. 2013.PubMed/NCBI

7 

Heffron TG, Coventry S, Bedendo F and Baker A: Resection of primary schwannoma of the liver not associated with neurofibromatosis. Arch Surg. 128:1396–1398. 1993. View Article : Google Scholar : PubMed/NCBI

8 

Iddings DM, Wright BE and Bilchik A: A rare cause of primary hepatic neoplasm: Malignant peripheral nerve sheath tumor in the age of modern liver surgery. Am Surg. 74:47–50. 2008.PubMed/NCBI

9 

Kobori L, Nagy P, Mathe Z, Hartmann E, Doros A, Paku S, Dezso K and Sápi Z: Malignant peripheral nerve sheath tumor of the liver: A case report. Pathol Oncol Res. 14:329–332. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Morikawa Y, Ishihara Y, Matsuura N, Miyamoto H and Kakudo K: Malignant schwannoma of the liver. Dig Dis Sci. 40:1279–1282. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Zhang L, Yu R and Chen Y: Primary hepatic benign schwannoma: Case report. Chin J Radiol. 42:10682008.(In Chinese).

12 

Wada Y, Jimi A, Nakashima O, Kojiro M, Kurohiji T and Sai K: Schwannoma of the liver: Report of two surgical cases. Pathol Int. 48:611–617. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Akin M, Bozkirli B, Leventoglu S, Unal K, Kapucu LO, Akyurek N and Sare M: Liver schwannoma incidentally discovered in a patient with breast cancer. Bratisl Lek Listy. 110:298–300. 2009.PubMed/NCBI

14 

Kim YC and Park MS: Primary hepatic schwannoma mimicking malignancy on fluorine-18 2-fluoro-2-deoxy-D-glucose positron emission tomography-computed tomography. Hepatology. 51:1080–1081. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Xu L, Zhou X and Qian H: Small bowel stromal tumors associated with hepatic schwannoma: Case report. Chin J Bases Clin General Surg. 14:7422007.(In Chinese).

16 

Piao G: One Case: Liver Schwannoma. J Pract Radiol. 25:13432009.(In Chinese).

17 

Hayashi M, Takeshita A, Yamamoto K and Tanigawa N: Primary hepatic benign schwannoma. World J Gastrointest Surg. 4:73–8. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Kapoor S, Tevatia MS, Dattagupta S and Chattopadhyay TK: Primary hepatic nerve sheath tumor. Liver Int. 25:458–9. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Yoshida M, Nakashima Y, Tanaka A, Mori K and Yamaoka Y: Benign schwannoma of the liver: A case report. Nihon Geka Hokan. 63:208–214. 1994.PubMed/NCBI

20 

Flemming P, Frerker M, Klempnauer J and Pichlmayr R: Benign schwannoma of the liver with cystic changes misinterpreted as hydatid disease. Hepatogastroenterology. 45:1764–1766. 1998.PubMed/NCBI

21 

Jin L and Zhou Y: A case of hepatic schwannoma misdiagnosed as liver abscess. Chin J Dig. 22:62002.

22 

Momtahen AJ, Akduman EI, Balci NC, Fattahi R and Havlioglu N: Liver schwannoma: Findings on MRI. Magn Reson Imaging. 26:1442–1445. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Liu Y: A case of huge hepatic schwannoma for liver transplantation. Chin network dynamics of infectious diseases. 45. 2005.(In Chinese).

24 

Lee WH, Kim TH, You SS, Choi SP, Min HJ, Kim HJ, Lee OJ and Ko GH: Benign schwannoma of the liver: A case report. J Korean Med Sci. 23:727–730. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Young SJ: Primary malignant neurilemmona (schwannoma) of the liver in a case of neurofibromatosis. J Pathol. 117:151–153. 1975. View Article : Google Scholar : PubMed/NCBI

26 

Lederman SM, Martin EC, Laffey KT and Lefkowitch JH: Hepatic neurofibromatosis, malignant schwannoma and angiosarcoma in von Recklinghausen's disease. Gastroenterology. 92:234–239. 1987.PubMed/NCBI

27 

Yu C, Li S and Zhang Z and Zhang Z: A case of massive hepatic malignant schwannoma. Chin J Pract Oncol. 308:1999.(In Chinese).

28 

Fiel MI, Schwartz M, Min AD, Sung MW and Thung SN: Malignant schwannoma of the liver in a patient without neurofibromatosis: A case report and review of the literature. Arch Pathol Lab Med. 120:1145–1147. 1996.PubMed/NCBI

29 

Fang X and Li C: Primary malignant schwannoma of the liver: Case report. J Hepatopancreatbiliary Surgery. 11:2021999.(In Chinese).

30 

Tengfei Li, Zhen Wu, Gang Wu and Han X: Hepatic malignant schwannoma in von Recklinghausen's disease: Case report. Chin J CT and MRI. 7:77–78. 2009.(In Chinese).

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Copy and paste a formatted citation
Spandidos Publications style
Wan DL, Zhai ZL, Ren KW, Yang YC, Lin SZ and Zheng SS: Hepatic schwannoma: A case report and an updated 40-year review of the literature yielding 30 cases. Mol Clin Oncol 4: 959-964, 2016.
APA
Wan, D., Zhai, Z., Ren, K., Yang, Y., Lin, S., & Zheng, S. (2016). Hepatic schwannoma: A case report and an updated 40-year review of the literature yielding 30 cases. Molecular and Clinical Oncology, 4, 959-964. https://doi.org/10.3892/mco.2016.850
MLA
Wan, D., Zhai, Z., Ren, K., Yang, Y., Lin, S., Zheng, S."Hepatic schwannoma: A case report and an updated 40-year review of the literature yielding 30 cases". Molecular and Clinical Oncology 4.6 (2016): 959-964.
Chicago
Wan, D., Zhai, Z., Ren, K., Yang, Y., Lin, S., Zheng, S."Hepatic schwannoma: A case report and an updated 40-year review of the literature yielding 30 cases". Molecular and Clinical Oncology 4, no. 6 (2016): 959-964. https://doi.org/10.3892/mco.2016.850
Copy and paste a formatted citation
x
Spandidos Publications style
Wan DL, Zhai ZL, Ren KW, Yang YC, Lin SZ and Zheng SS: Hepatic schwannoma: A case report and an updated 40-year review of the literature yielding 30 cases. Mol Clin Oncol 4: 959-964, 2016.
APA
Wan, D., Zhai, Z., Ren, K., Yang, Y., Lin, S., & Zheng, S. (2016). Hepatic schwannoma: A case report and an updated 40-year review of the literature yielding 30 cases. Molecular and Clinical Oncology, 4, 959-964. https://doi.org/10.3892/mco.2016.850
MLA
Wan, D., Zhai, Z., Ren, K., Yang, Y., Lin, S., Zheng, S."Hepatic schwannoma: A case report and an updated 40-year review of the literature yielding 30 cases". Molecular and Clinical Oncology 4.6 (2016): 959-964.
Chicago
Wan, D., Zhai, Z., Ren, K., Yang, Y., Lin, S., Zheng, S."Hepatic schwannoma: A case report and an updated 40-year review of the literature yielding 30 cases". Molecular and Clinical Oncology 4, no. 6 (2016): 959-964. https://doi.org/10.3892/mco.2016.850
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