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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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July-2016 Volume 5 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-2016 Volume 5 Issue 1

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Case Report

Anaplastic lymphoma kinase‑positive squamous cell carcinoma of the lung: A case report

  • Authors:
    • Yoko Yamamoto
    • Ken Kodama
    • Tomohiro Maniwa
    • Masashi Takeda
    • Hiroki Kishima

  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Yao Municipal Hospital, Yao, Osaka 581‑0069, Japan, Department of Pathology, Yao Municipal Hospital, Yao, Osaka 581‑0069, Japan, Department of Surgery, Kishima Hospital Main Division, Yao, Osaka 581‑0069, Japan
  • Pages: 61-63
    |
    Published online on: April 26, 2016
       https://doi.org/10.3892/mco.2016.878
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Abstract

It is widely known that echinoderm microtubule‑associated protein‑like 4 anaplastic lymphoma kinase (EML4‑ALK) rearrangement mostly occurs in the adenocarcinoma subtype of non‑small‑cell lung cancer (NSCLC). Patients with squamous cell carcinoma harboring the ALK rearrangement are extremely rare. This is a case report of a squamous cell carcinoma patient with EML4‑ALK rearrangement. An elderly man with a heavy smoking history presented with a mass lesion in the right main bronchus. Bronchoscopic biopsy of the tumor confirmed a diagnosis of squamous cell carcinoma, and it was proven to harbor ALK rearrangement, based on fluorescence in situ hybridization, but not epidermal growth factor receptor mutations. The patient underwent radiation therapy, with a markedly favorable response. ALK‑targeted treatment may be a viable option if disease progression occurs in such a case in the future.
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Shaw AT, Yeap BY, Mino-Knudson M, Digumarthy SR, Costa DB, Heist RS, Solomon B, Stubbs H, Admane S, McDermott U, et al: Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 27:4247–4253. 2009. View Article : Google Scholar : PubMed/NCBI

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Caliò A, Nottegar A, Gilioli E, Bria E, Pilotto S, Peretti U, Kinspergher S, Simonato F, Pedron S, Knuutila S, et al: ALK/EML4 fusion gene may be found in pure squamous carcinoma of the lung. J Thorac Oncol. 9:729–732. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yamamoto Y, Kodama K, Maniwa T, Takeda M and Kishima H: Anaplastic lymphoma kinase‑positive squamous cell carcinoma of the lung: A case report. Mol Clin Oncol 5: 61-63, 2016.
APA
Yamamoto, Y., Kodama, K., Maniwa, T., Takeda, M., & Kishima, H. (2016). Anaplastic lymphoma kinase‑positive squamous cell carcinoma of the lung: A case report. Molecular and Clinical Oncology, 5, 61-63. https://doi.org/10.3892/mco.2016.878
MLA
Yamamoto, Y., Kodama, K., Maniwa, T., Takeda, M., Kishima, H."Anaplastic lymphoma kinase‑positive squamous cell carcinoma of the lung: A case report". Molecular and Clinical Oncology 5.1 (2016): 61-63.
Chicago
Yamamoto, Y., Kodama, K., Maniwa, T., Takeda, M., Kishima, H."Anaplastic lymphoma kinase‑positive squamous cell carcinoma of the lung: A case report". Molecular and Clinical Oncology 5, no. 1 (2016): 61-63. https://doi.org/10.3892/mco.2016.878
Copy and paste a formatted citation
x
Spandidos Publications style
Yamamoto Y, Kodama K, Maniwa T, Takeda M and Kishima H: Anaplastic lymphoma kinase‑positive squamous cell carcinoma of the lung: A case report. Mol Clin Oncol 5: 61-63, 2016.
APA
Yamamoto, Y., Kodama, K., Maniwa, T., Takeda, M., & Kishima, H. (2016). Anaplastic lymphoma kinase‑positive squamous cell carcinoma of the lung: A case report. Molecular and Clinical Oncology, 5, 61-63. https://doi.org/10.3892/mco.2016.878
MLA
Yamamoto, Y., Kodama, K., Maniwa, T., Takeda, M., Kishima, H."Anaplastic lymphoma kinase‑positive squamous cell carcinoma of the lung: A case report". Molecular and Clinical Oncology 5.1 (2016): 61-63.
Chicago
Yamamoto, Y., Kodama, K., Maniwa, T., Takeda, M., Kishima, H."Anaplastic lymphoma kinase‑positive squamous cell carcinoma of the lung: A case report". Molecular and Clinical Oncology 5, no. 1 (2016): 61-63. https://doi.org/10.3892/mco.2016.878
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