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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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October-2016 Volume 5 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Trefoil factor 3 expression in epithelial ovarian cancer exerts a minor effect on clinicopathological parameters

  • Authors:
    • Friederike Hoellen
    • Athina Kostara
    • Thomas Karn
    • Uwe Holtrich
    • Ahmed El‑Balat
    • Mike Otto
    • Achim Rody
    • Lars C. Hanker

  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, University of Lübeck, D‑23538 Lübeck, Germany, Department of Obstetrics and Gynecology, Goethe University, D‑60323 Frankfurt, Germany, Medical Center for Histopathology, Cytology and Molecular Diagnostics, D‑54296 Trier, Germany
  • Pages: 422-428
    |
    Published online on: August 17, 2016
       https://doi.org/10.3892/mco.2016.994
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Abstract

The role of trefoil factor 3 (intestinal) (TFF3) has been analyzed in numerous cancers, such as breast and gastrointestinal cancer, and has been associated with poor prognosis. However, the role of TFF3 in ovarian cancers is not clear. Expression analysis of TFF3 in 91 ovarian cancer patients was performed by immunohistochemistry of primary paraffin‑embedded tumor samples. The results were scored according to staining intensity and percentage of positive tumor cells resulting in an immune‑reactive score (IRS) of 0‑12. These results were correlated with clinicopathological characteristics and survival. TFF3 expression in our patient cohort exhibited a tendency towards improved overall and progression‑free survival (PFS). In TFF3‑positive serous and high‑grade serous ovarian cancers, the median PFS was 27.6 months [95% confidence interval (CI): 0‑55.7] vs. 15.2 months in TFF3‑negative tumors (95% CI: 13.8‑16.6) (P=0.183). The median overall survival was 53.9 months in TFF3‑positive tumors (95% CI: Non‑applicable) vs. 44.4 months in TFF3‑negative cases (95% CI: 30.5‑58.3) (P=0.36). TFF3 negativity was significantly associated with higher tumor grade (P=0.05). Based on our results, further studies are required in order to elucidate whether survival and chemosensitivity are affected by TFF3 expression in ovarian cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Hoellen F, Kostara A, Karn T, Holtrich U, El‑Balat A, Otto M, Rody A and Hanker LC: Trefoil factor 3 expression in epithelial ovarian cancer exerts a minor effect on clinicopathological parameters. Mol Clin Oncol 5: 422-428, 2016.
APA
Hoellen, F., Kostara, A., Karn, T., Holtrich, U., El‑Balat, A., Otto, M. ... Hanker, L.C. (2016). Trefoil factor 3 expression in epithelial ovarian cancer exerts a minor effect on clinicopathological parameters. Molecular and Clinical Oncology, 5, 422-428. https://doi.org/10.3892/mco.2016.994
MLA
Hoellen, F., Kostara, A., Karn, T., Holtrich, U., El‑Balat, A., Otto, M., Rody, A., Hanker, L. C."Trefoil factor 3 expression in epithelial ovarian cancer exerts a minor effect on clinicopathological parameters". Molecular and Clinical Oncology 5.4 (2016): 422-428.
Chicago
Hoellen, F., Kostara, A., Karn, T., Holtrich, U., El‑Balat, A., Otto, M., Rody, A., Hanker, L. C."Trefoil factor 3 expression in epithelial ovarian cancer exerts a minor effect on clinicopathological parameters". Molecular and Clinical Oncology 5, no. 4 (2016): 422-428. https://doi.org/10.3892/mco.2016.994
Copy and paste a formatted citation
x
Spandidos Publications style
Hoellen F, Kostara A, Karn T, Holtrich U, El‑Balat A, Otto M, Rody A and Hanker LC: Trefoil factor 3 expression in epithelial ovarian cancer exerts a minor effect on clinicopathological parameters. Mol Clin Oncol 5: 422-428, 2016.
APA
Hoellen, F., Kostara, A., Karn, T., Holtrich, U., El‑Balat, A., Otto, M. ... Hanker, L.C. (2016). Trefoil factor 3 expression in epithelial ovarian cancer exerts a minor effect on clinicopathological parameters. Molecular and Clinical Oncology, 5, 422-428. https://doi.org/10.3892/mco.2016.994
MLA
Hoellen, F., Kostara, A., Karn, T., Holtrich, U., El‑Balat, A., Otto, M., Rody, A., Hanker, L. C."Trefoil factor 3 expression in epithelial ovarian cancer exerts a minor effect on clinicopathological parameters". Molecular and Clinical Oncology 5.4 (2016): 422-428.
Chicago
Hoellen, F., Kostara, A., Karn, T., Holtrich, U., El‑Balat, A., Otto, M., Rody, A., Hanker, L. C."Trefoil factor 3 expression in epithelial ovarian cancer exerts a minor effect on clinicopathological parameters". Molecular and Clinical Oncology 5, no. 4 (2016): 422-428. https://doi.org/10.3892/mco.2016.994
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