Efficacy of metformin for advanced-stage endometrial cancer: A case report

Sato,Emi; Nakayama,Kentaro; Nakamura,Kohei; Ishikawa,Noriyoshi; Ishikawa,Masako; Minamoto,Toshiko; Ishibashi,Tomoka; Kyo,Satoru

doi:10.3892/mco.2017.1130

March-2017 Volume 6 Issue 3

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March-2017 Volume 6 Issue 3

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Case Report

Efficacy of metformin for advanced-stage endometrial cancer: A case report

Authors:
- Emi Sato
- Kentaro Nakayama
- Kohei Nakamura
- Noriyoshi Ishikawa
- Masako Ishikawa
- Toshiko Minamoto
- Tomoka Ishibashi
- Satoru Kyo
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynaecology, Shimane University School of Medicine, Izumo, Shimane 6938501, Japan, Department of Organ Pathology, Shimane University School of Medicine, Izumo, Shimane 6938501, Japan
Pages: 441-443
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Published online on: January 13, 2017

https://doi.org/10.3892/mco.2017.1130
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Abstract

The paradigm of obesity, diabetes mellitus and insulin resistance possibly plays a critical role in the pathogenesis of endometrial cancer (EC). Impaired glucose tolerance and insulin resistance may play a direct or facilitating role in the neoplastic transformation of the endometrium, whereas antidiabetic therapy, particularly with metformin, has been suggested to inhibit EC progression. We herein present the case of a patient with EC who received metformin monotherapy due to complications after undergoing surgery. At 45 months after the introduction of metformin treatment, the patient had no complaints and continued receiving metformin without signs of tumor recurrence. As metformin is widely used among diabetic patients and in ongoing clinical trials in cancer patients, the aforementioned results deserve further clinical investigation.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Efficacy of metformin for advanced-stage endometrial cancer: A case report

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Abstract

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