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Molecular and Clinical Oncology
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Case Report Open Access

Biliary intraductal papillary neoplasm with metachronous multiple tumors - true multicentric tumors or intrabiliary dissemination: A case report and review of the literature

  • Authors:
    • Masataka Yokode
    • Yukimasa Yamashita
    • Yoh Zen
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Kobe City Medical Center West Hospital, Kobe, Hyogo 653-0013, Japan, Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan
    Copyright: © Yokode et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 315-320
    |
    Published online on: January 23, 2017
       https://doi.org/10.3892/mco.2017.1139
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Abstract

Intraductal papillary neoplasms of the bile duct (IPNBs) are recognized as a distinct type of biliary tumor. We herein discuss the possible mechanisms underlying the development of multiple tumors in patients with IPNBs through a case presentation and literature review. A 64-year-old woman initially underwent extended right hepatectomy for IPNB in the right hepatic duct. Although the surgical margin of the common bile duct was tumor-free, recurrence was detected in the intrapancreatic bile duct 26 months later. Both tumors had similar histopathological characteristics (intestinal-type IPNB with high-grade dysplasia, but no invasive cancer). A literature review identified 9 additional cases of multiple IPNBs. Unlike conventional IPNBs, which typically affect the intrahepatic or hilar bile duct, 80% of recurrent multiple tumors developed in the extrahepatic bile duct. Although multicentric tumors have been suggested in such cases, the intrabiliary dissemination of tumor cells appears to be more likely, as the majority of recurrent tumors develop in more distal parts of the bile duct compared with the primary tumor.
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Copy and paste a formatted citation
Spandidos Publications style
Yokode M, Yamashita Y and Zen Y: Biliary intraductal papillary neoplasm with metachronous multiple tumors - true multicentric tumors or intrabiliary dissemination: A case report and review of the literature. Mol Clin Oncol 6: 315-320, 2017.
APA
Yokode, M., Yamashita, Y., & Zen, Y. (2017). Biliary intraductal papillary neoplasm with metachronous multiple tumors - true multicentric tumors or intrabiliary dissemination: A case report and review of the literature. Molecular and Clinical Oncology, 6, 315-320. https://doi.org/10.3892/mco.2017.1139
MLA
Yokode, M., Yamashita, Y., Zen, Y."Biliary intraductal papillary neoplasm with metachronous multiple tumors - true multicentric tumors or intrabiliary dissemination: A case report and review of the literature". Molecular and Clinical Oncology 6.3 (2017): 315-320.
Chicago
Yokode, M., Yamashita, Y., Zen, Y."Biliary intraductal papillary neoplasm with metachronous multiple tumors - true multicentric tumors or intrabiliary dissemination: A case report and review of the literature". Molecular and Clinical Oncology 6, no. 3 (2017): 315-320. https://doi.org/10.3892/mco.2017.1139
Copy and paste a formatted citation
x
Spandidos Publications style
Yokode M, Yamashita Y and Zen Y: Biliary intraductal papillary neoplasm with metachronous multiple tumors - true multicentric tumors or intrabiliary dissemination: A case report and review of the literature. Mol Clin Oncol 6: 315-320, 2017.
APA
Yokode, M., Yamashita, Y., & Zen, Y. (2017). Biliary intraductal papillary neoplasm with metachronous multiple tumors - true multicentric tumors or intrabiliary dissemination: A case report and review of the literature. Molecular and Clinical Oncology, 6, 315-320. https://doi.org/10.3892/mco.2017.1139
MLA
Yokode, M., Yamashita, Y., Zen, Y."Biliary intraductal papillary neoplasm with metachronous multiple tumors - true multicentric tumors or intrabiliary dissemination: A case report and review of the literature". Molecular and Clinical Oncology 6.3 (2017): 315-320.
Chicago
Yokode, M., Yamashita, Y., Zen, Y."Biliary intraductal papillary neoplasm with metachronous multiple tumors - true multicentric tumors or intrabiliary dissemination: A case report and review of the literature". Molecular and Clinical Oncology 6, no. 3 (2017): 315-320. https://doi.org/10.3892/mco.2017.1139
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