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Case Report Open Access

Doceaqualip in a patient with prostate cancer who had an allergic reaction to conventional docetaxel: A case report

  • Authors:
    • Radheshyam Naik
    • Mujtaba A. Khan
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, HCG Hospital, Bangalore, Karnataka 560027, India, Department of Medical Affairs, Intas Pharmaceuticals Ltd., Ahmedabad, Gujarat 382210, India
    Copyright: © Naik et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 341-343
    |
    Published online on: February 2, 2017
       https://doi.org/10.3892/mco.2017.1147
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Abstract

Docetaxel has been widely used in the treatment of several cancers, including adenocarcinoma of the prostate gland. As docetaxel is insoluble in water, it must be administered with polysorbate 80 and ethanol, which are known to cause hypersensitivity reactions. Premedication with corticosteroids and antihistamines is advocated prior to docetaxel administration; however, toxicities, occasionally fatal, have been reported, even with corticosteroid premedication. We herein report the case of a patient with adenocarcinoma of the prostate, with bone metastasis and an Eastern Cooperative Oncology Group performance status of <2, who developed an allergic reaction to conventional docetaxel (Taxotere), despite being premedicated with corticosteroids and antihistamines. The patient was managed with corticosteroids and antihistamines, and was later started on Doceaqualip, a nanosomal docetaxel lipid suspension. Doceaqualip was well-tolerated by the patient and 5 cycles were subsequently administered, without any adverse reactions. Adenocarcinoma also regressed, as evidenced by positron emission tomography/computed tomography.
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Copy and paste a formatted citation
Spandidos Publications style
Naik R and Khan MA: Doceaqualip in a patient with prostate cancer who had an allergic reaction to conventional docetaxel: A case report. Mol Clin Oncol 6: 341-343, 2017.
APA
Naik, R., & Khan, M.A. (2017). Doceaqualip in a patient with prostate cancer who had an allergic reaction to conventional docetaxel: A case report. Molecular and Clinical Oncology, 6, 341-343. https://doi.org/10.3892/mco.2017.1147
MLA
Naik, R., Khan, M. A."Doceaqualip in a patient with prostate cancer who had an allergic reaction to conventional docetaxel: A case report". Molecular and Clinical Oncology 6.3 (2017): 341-343.
Chicago
Naik, R., Khan, M. A."Doceaqualip in a patient with prostate cancer who had an allergic reaction to conventional docetaxel: A case report". Molecular and Clinical Oncology 6, no. 3 (2017): 341-343. https://doi.org/10.3892/mco.2017.1147
Copy and paste a formatted citation
x
Spandidos Publications style
Naik R and Khan MA: Doceaqualip in a patient with prostate cancer who had an allergic reaction to conventional docetaxel: A case report. Mol Clin Oncol 6: 341-343, 2017.
APA
Naik, R., & Khan, M.A. (2017). Doceaqualip in a patient with prostate cancer who had an allergic reaction to conventional docetaxel: A case report. Molecular and Clinical Oncology, 6, 341-343. https://doi.org/10.3892/mco.2017.1147
MLA
Naik, R., Khan, M. A."Doceaqualip in a patient with prostate cancer who had an allergic reaction to conventional docetaxel: A case report". Molecular and Clinical Oncology 6.3 (2017): 341-343.
Chicago
Naik, R., Khan, M. A."Doceaqualip in a patient with prostate cancer who had an allergic reaction to conventional docetaxel: A case report". Molecular and Clinical Oncology 6, no. 3 (2017): 341-343. https://doi.org/10.3892/mco.2017.1147
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