Determination of adequate pelvic lymph node dissection range for Japanese males undergoing radical prostatectomy

Furubayashi,Nobuki; Negishi,Takahito; Iwai,Hidenori; Nagase,Kei; Taguchi,Kenichi; Shimokawa,Mototsugu; Nakamura,Motonobu

doi:10.3892/mco.2017.1204

May-2017 Volume 6 Issue 5

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May-2017 Volume 6 Issue 5

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Article

Determination of adequate pelvic lymph node dissection range for Japanese males undergoing radical prostatectomy

Authors:
- Nobuki Furubayashi
- Takahito Negishi
- Hidenori Iwai
- Kei Nagase
- Kenichi Taguchi
- Mototsugu Shimokawa
- Motonobu Nakamura
View Affiliations / Copyright

Affiliations: Department of Urology, National Kyushu Cancer Center, Fukuoka 811‑1395, Japan, Department of Pathology, National Kyushu Cancer Center, Fukuoka 811‑1395, Japan, Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka 811‑1395, Japan
Pages: 775-781
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Published online on: March 28, 2017

https://doi.org/10.3892/mco.2017.1204
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Abstract

The present study aimed to determine the adequate pelvic lymph node dissection (PLND) range for Japanese males undergoing radical prostatectomy. A total of 467 Japanese patients who underwent antegrade radical prostatectomy at the National Kyushu Cancer Center (Fukuoka, Japan) were retrospectively reviewed. The patients were divided into two groups according to the PLND extent: The standard (obturator + internal iliac nodes) group and the expanded (standard + additional nodes) group, which accounted for 64.5% (301/467) and 35.5% (166/467) of the patients, respectively. No differences were observed in the preoperative and postoperative characteristics of the two groups. In addition, there was no difference in PSA recurrence between the two groups. There were no differences between the standard and expanded groups in the low‑, intermediate‑ and high‑risk groups (P=0.1456, P=0.1581, P=0.2125, respectively). The median number of lymph node dissection was 13 and 19, in the standard and expanded groups respectively (P<0.0001). However, regarding the number of lymph node metastases and the rate of patients with lymph node metastasis, no significant difference was observed between the standard and expanded groups (P=0.4219 and P=0.4257, respectively). According to multivariate analysis, a significant difference in the presence of lymph node metastasis (hazard ratio 3.547; P=0.0247), but not in the PLND extent, was detected in patients with prostate specific antigen failure (P=0.0655). When expanding the dissection extent, the number of dissected lymph nodes increases, but is not associated with the number or rate of positive lymph nodes. Thus, the current dissection range is considered to be appropriate for Japanese men undergoing radical prostatectomy.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Determination of adequate pelvic lymph node dissection range for Japanese males undergoing radical prostatectomy

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Abstract

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