Management of infusion reactions associated with cetuximab treatment: A case report

Ohshita,Naohiro; Ichimaru,Yuri; Gamoh,Shoko; Tsuji,Kaname; Kishimoto,Naotaka; Tsutsumi,Yasuo  M.; Momota,Yoshihiro

doi:10.3892/mco.2017.1242

June-2017 Volume 6 Issue 6

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June-2017 Volume 6 Issue 6

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Case Report Open Access

Management of infusion reactions associated with cetuximab treatment: A case report

Authors:
- Naohiro Ohshita
- Yuri Ichimaru
- Shoko Gamoh
- Kaname Tsuji
- Naotaka Kishimoto
- Yasuo M. Tsutsumi
- Yoshihiro Momota
View Affiliations / Copyright

Affiliations: Department of Anesthesiology, Osaka Dental University, Osaka 540-0008, Japan, Department of Oral Radiology, Osaka Dental University, Osaka 540-0008, Japan, First Department of Oral and Maxillofacial Surgery, Osaka Dental University, Osaka 540-0008, Japan, Department of Anesthesiology, Faculty of Medicine, Tokushima University, Tokushima 770-8503, Japan

Copyright: © Ohshita et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 853-855
|
Published online on: May 5, 2017

https://doi.org/10.3892/mco.2017.1242
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Abstract

Cetuximab is a drug targeting the epidermal growth factor receptor, which is indicated for the treatment of unresectable advanced or recurrent head and neck or colorectal cancer. Cetuximab also enhances the cytotoxic effects of radiation in squamous cell carcinoma. The severity of infusion reactions (IR) is categorized from grade 1 to 5; grades 3 and 4 are associated with life-threatening reactions (anaphylaxis), whereas grade 5 indicates death. The incidence of grade 3‑4 IR with premedication is reported to be 1.1%. We herein describe a case of a 77-year-old man who developed IR during intravenous administration of cetuximab. The patient developed grade 3-4 anaphylaxis with pruritus, rash and urticaria, followed by hypotension and bradycardia. The timely diagnosis and treatment with intravenous infusion of a vasopressor drug and Ringer's acetate solution proved to be effective. The case presented herein demonstrated an unfeatured aspect of cetuximab‑related IR as dermatological reactions over the entire body followed by circulatory collapse.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Management of infusion reactions associated with cetuximab treatment: A case report

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Abstract

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