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Article

Combination therapy with gemcitabine and nab‑paclitaxel for locally advanced unresectable pancreatic cancer

  • Authors:
    • Takeshi Saito
    • Keinosuke Ishido
    • Daisuke Kudo
    • Norihisa Kimura
    • Taiichi Wakiya
    • Yoshihito Nakayama
    • Kenichi Hakamada
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan
  • Pages: 963-967
    |
    Published online on: May 8, 2017
       https://doi.org/10.3892/mco.2017.1251
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Abstract

The aim of the present study was to investigate the early treatment outcomes of combined gemcitabine and nab‑paclitaxel treatment for locally advanced unresectable pancreatic cancer (LURPC). The subjects comprised 7 patients with LURPC receiving the abovementioned combination therapy at the Hirosaki University Hospital (Hirosaki, Japan) between January and September, 2015. The clinicopathological factors, adverse events and response to treatment were investigated. To determine whether the cases were unresectable, the National Comprehensive Cancer Network guidelines, version 2. 201,) were applied. The patients underwent a median of 4 (range, 2‑7) courses of treatment. The response to treatment was evaluated using the Response Evaluation Criteria In Solid Tumors. The subjects included 1 male and 6 female LURPC patients, with a median age of 71 years (range, 59‑78 years). The tumor was located in the head and body of the pancreas in 6 and 1 patients, respectively. No patients achieved a complete response, 5 achieved a partial response, 2 had stable disease, and none exhibited progressive disease. The response rate was 71%. The mean tumor diameter decreased significantly from 35 mm (range, 24‑60 mm) prior to treatment to 22 mm (range, 20‑35 mm) following treatment. Two patients were downstaged. The mean carbohydrate antigen (CA) 19‑9 values decreased significantly from 767 U/ml (range, 14‑1,977 U/ml) prior to treatment to 35 U/ml (range, 14‑123 U/ml) following treatment. Adverse events classified as grade ≥3 occurred in 4 patients (57%): 3 patients (43%) suffered from neutropenia and 1 patient (14%) developed bilateral cellulitis of the lower extremities. No patients experienced an increase in disease severity, and all were able to continue treatment following temporary withdrawal or dosage reduction. Therefore, combined treatment with gemcitabine and nab‑paclitaxel had favorable tumor‑reducing effects and was not associated with severe adverse events, suggesting that this is a useful therapeutic strategy for patients with LURPC.
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Copy and paste a formatted citation
Spandidos Publications style
Saito T, Ishido K, Kudo D, Kimura N, Wakiya T, Nakayama Y and Hakamada K: Combination therapy with gemcitabine and nab‑paclitaxel for locally advanced unresectable pancreatic cancer. Mol Clin Oncol 6: 963-967, 2017.
APA
Saito, T., Ishido, K., Kudo, D., Kimura, N., Wakiya, T., Nakayama, Y., & Hakamada, K. (2017). Combination therapy with gemcitabine and nab‑paclitaxel for locally advanced unresectable pancreatic cancer. Molecular and Clinical Oncology, 6, 963-967. https://doi.org/10.3892/mco.2017.1251
MLA
Saito, T., Ishido, K., Kudo, D., Kimura, N., Wakiya, T., Nakayama, Y., Hakamada, K."Combination therapy with gemcitabine and nab‑paclitaxel for locally advanced unresectable pancreatic cancer". Molecular and Clinical Oncology 6.6 (2017): 963-967.
Chicago
Saito, T., Ishido, K., Kudo, D., Kimura, N., Wakiya, T., Nakayama, Y., Hakamada, K."Combination therapy with gemcitabine and nab‑paclitaxel for locally advanced unresectable pancreatic cancer". Molecular and Clinical Oncology 6, no. 6 (2017): 963-967. https://doi.org/10.3892/mco.2017.1251
Copy and paste a formatted citation
x
Spandidos Publications style
Saito T, Ishido K, Kudo D, Kimura N, Wakiya T, Nakayama Y and Hakamada K: Combination therapy with gemcitabine and nab‑paclitaxel for locally advanced unresectable pancreatic cancer. Mol Clin Oncol 6: 963-967, 2017.
APA
Saito, T., Ishido, K., Kudo, D., Kimura, N., Wakiya, T., Nakayama, Y., & Hakamada, K. (2017). Combination therapy with gemcitabine and nab‑paclitaxel for locally advanced unresectable pancreatic cancer. Molecular and Clinical Oncology, 6, 963-967. https://doi.org/10.3892/mco.2017.1251
MLA
Saito, T., Ishido, K., Kudo, D., Kimura, N., Wakiya, T., Nakayama, Y., Hakamada, K."Combination therapy with gemcitabine and nab‑paclitaxel for locally advanced unresectable pancreatic cancer". Molecular and Clinical Oncology 6.6 (2017): 963-967.
Chicago
Saito, T., Ishido, K., Kudo, D., Kimura, N., Wakiya, T., Nakayama, Y., Hakamada, K."Combination therapy with gemcitabine and nab‑paclitaxel for locally advanced unresectable pancreatic cancer". Molecular and Clinical Oncology 6, no. 6 (2017): 963-967. https://doi.org/10.3892/mco.2017.1251
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