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Article

Erythropoietin for cancer-associated malignant anemia: A meta-analysis

  • Authors:
    • Feng Zhao
    • Yijuan Wang
    • Lin Liu
    • Meiling Bian
  • View Affiliations / Copyright

    Affiliations: Department of Blood Transfusion Medicine, Linzi District People's Hospital, Binzhou Medical University, Zibo, Shandong 255400, P.R. China, Medical Intensive Care Unit, PKU Care Luzhong Hospital, Zibo, Shandong 255400, P.R. China, Department of Internal Medicine, Linzi District People's Hospital, Binzhou Medical University, Zibo, Shandong 255400, P.R. China
  • Pages: 925-930
    |
    Published online on: May 8, 2017
       https://doi.org/10.3892/mco.2017.1254
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Abstract

The present study aimed to evaluate the effectiveness of erythropoietin (EPO) for improving cancer‑associated malignant anemia. A search was performed for randomized clinical trials, conducted according to the Cochrane manual, using electronic databases including PubMed, EMBASE, the Cochrane Library and ClinicalTrails.gov up to 15 August 2015. A total of 6 eligible studies from 5 articles enrolling a total of 453 patients were entered into the current meta-analysis. Upon EPO treatment, there were significant differences in the change in hemoglobin (HB) levels compared with the placebo at short‑term follow‑up [mean difference (MD)=0.66; 95% confidence interval (CI), 0.14‑1.18; I2=Not applicable; P=0.01) and long‑term follow‑up (MD=0.10; 95% CI, 0.02‑0.18; I2=Not applicable; P=0.01) under the random effects model. For changes in hematocrit (HCT) compared with the placebo, the results revealed there were significant differences at short‑term follow‑up (MD=2.47; 95% CI, 0.75‑4.19; I2=Not applicable; P=0.005) and long‑term follow‑up (MD=7.60; 95% CI, 6.15‑9.05; I2=Not applicable; P<0.00001) under the random effects model. Compared with the placebo in short‑term follow‑up under the fixed effects model with homogeneity, the result was a significant difference for the transfusion ratio [relative risk (RR)=0.81; 95% CI, 0.67‑ 0.97; I2=34%; P=0.02) and the transfusion requirements (MD=‑0.45; 95% CI, ‑0.92, 0.03; I2=6%; P=0.07). Funnel plots did not detect any publication bias. These results suggest that EPO was beneficial to alleviate cancer‑associated anemia and improve survival outcomes for patients with cancer.
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1 

Mercadante S, Gebbia V, Marrazzo A and Filosto S: Anaemia in cancer: Pathophysiology and treatment. Cancer Treat Rev. 26:303–311. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Henry DH: Supplemental Iron: A key to optimizing the response of cancer-related anemia to rHuEPO? Oncologist. 3:275–278. 1998.PubMed/NCBI

3 

Kasper C, Terhaar A, Fosså A, Welt A, Seeber S and Nowrousian MR: Recombinant human erythropoietin in the treatment of cancer-related anaemia. Eur J Haematol. 58:251–216. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Pronzato P: Cancer-related anaemia management in the 21st century. Cancer Treat Rev. 32 Suppl 2:S1–S3. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Ludwig H, Evstatiev R, Kornek G, Aapro M, Bauernhofer T, Buxhofer-Ausch V, Fridrik M, Geissler D, Geissler K, Gisslinger H, et al: Iron metabolism and iron supplementation in cancer patients. Wien Klin Wochenschr. 127:907–919. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Littlewood TJ: Erythropoietin for the treatment of anemia associated with hematological malignancy. Hematol Oncol. 19:19–30. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Glaspy J: The impact of epoetin alfa on quality of life during cancer chemotherapy: A fresh look at an old problem. Semin Hematol. 34 3 Suppl 2:S20–S26. 1997.

8 

Brandberg Y: Assessing the impact of cancer-related anaemia on quality of life and the role of rHuEPO. Med Oncol. 17(Suppl 1): S23–S31. 2000.PubMed/NCBI

9 

Rice L, Alfrey CP, Driscoll T, Whitley CE, Hachey DL and Suki W: Neocytolysis contributes to the anemia of renal disease. Am J Kidney Dis. 33:59–62. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Leng HM, Albrecht CF, Kidson SH and Folb PI: Erythropoietin production in anemia associated with experimental cancer. Exp Hematol. 27:806–810. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Feelders RA, Vreugdenhil G, Eggermont AM, Kuiper-Kramer PA, van Eijk HG and Swaak AJ: Regulation of iron metabolism in the acute-phase response: Interferon gamma and tumour necrosis factor alpha induce hypoferraemia, ferritin production and a decrease in circulating transferrin receptors in cancer patients. Eur J Clin Invest. 28:520–527. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Chung IJ, Dai C and Krantz SB: Stem cell factor increases the expression of FLIP that inhibits IFNgamma -induced apoptosis in human erythroid progenitor cells. Blood. 101:1324–1328. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Rodriguez S and ánchez CA: Recommendation of the scientific societies on the treatment of anaemia in cancer patients. Clin Transl Oncol. 9:582–589. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Garcia JM Jurado, Sánchez E Torres, Hidalgo D Olmos and Alba Conejo E: Erythropoietin pharmacology. Clin Transl Oncol. 9:715–722. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Ahlqvist-Rastad J, Albertsson M, Bergh J, Birgegård G, Johansson P, Jonsson B, Kjellen E, Påhlman S, Zackrisson B and Osterborg A: Erythropoietin therapy and cancer related anaemia: Updated Swedish recommendations. Med Oncol. 24:267–272. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Deeks JJ: Issues in the selection of a summary statistic for meta-analysis of clinical trials with binary outcomes. Stat Med. 21:1575–1600. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Higgins J and Green S: Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration; 2011, simplewww.cochrane-handbook.orgOctober 1–2011

18 

Walter SD and Yao X: Effect sizes can be calculated for studies reporting ranges for outcome variables in systematic reviews. J Clin Epidemiol. 60:849–852. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Higgins JP and Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 21:1539–1558. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Henke M, Laszig R, Rübe C, Schäfer U, Haase KD, Schilcher B, Mose S, Beer KT, Burger U, Dougherty C and Frommhold H: Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: Randomised, double-blind, placebo-controlled trial. Lancet. 362:1255–1260. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Copas J and Shi JQ: Meta-analysis, funnel plots and sensitivity analysis. Biostatistics. 1:247–262. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Kettelhack C, Hönes C, Messinger D and Schlag PM: Randomized multicentre trial of the influence of recombinant human erythropoietin on intraoperative and postoperative transfusion need in anaemic patients undergoing right hemicolectomy for carcinoma. Br J Surg. 85:63–67. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Scott SN, Boeve TJ, McCulloch TM, Fitzpatrick KA and Karnell LH: The effects of epoetin alfa on transfusion requirements in head and neck cancer patients: A prospective, randomized, placebo-controlled study. Laryngoscope. 112:1221–1229. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Kosmadakis N, Messaris E, Maris A, Katsaragakis S, Leandros E, Konstadoulakis MM and Androulakis G: Perioperative erythropoietin administration in patients with gastrointestinal tract cancer: Prospective randomized double-blind study. Ann Surg. 237:417–421. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Christodoulakis M and Tsiftsis DD: Hellenic Surgical Oncology Perioperative EPO Study Group: Preoperative epoetin alfa in colorectal surgery: A randomized, controlled study. Ann Surg Oncol. 12:718–725. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Mystakidou K, Kalaidopoulou O, Katsouda E, Parpa E, Kouskouni E, Chondros C, Tsiatas ML and Vlahos L: Evaluation of epoetin supplemented with oral iron in patients with solid malignancies and chronic anemia not receiving anticancer treatment. Anticancer Res. 25:3495–3500. 2005.PubMed/NCBI

27 

Lacson E Jr, Ofsthun N and Lazarus JM: Effect of variability in anemia management on hemoglobin outcomes in ESRD. Am J Kidney Dis. 41:111–124. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Rainville N, Jachimowicz E and Wojchowski DM: Targeting EPO and EPO receptor pathways in anemia and dysregulated erythropoiesis. Expert Opin Ther Targets. 20:287–301. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Singh PK, Devasahayam M and Devi S: Expression of GPI anchored human recombinant erythropoietin in CHO cells is devoid ofglycosylation heterogeneity. Indian J Exp Biol. 53:195–201. 2015.PubMed/NCBI

30 

Aapro M: Emerging topics in anaemia and cancer. Ann Oncol. 23 Suppl 10:x289–x293. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Rice L and Alfrey CP: The negative regulation of red cell mass by neocytolysis: Physiologic and pathophysiologic manifestations. Cell Physiol Biochem. 15:245–250. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Means RT Jr and Krantz SB: Progress in understanding the pathogenesis of the anemia of chronic disease. Blood. 80:1639–1647. 1992.PubMed/NCBI

33 

Borstlap WA, Buskens CJ, Tytgat KM, Tuynman JB, Consten EC, Tolboom RC, Heuff G, van Geloven AA, van Wagensveld BA, Wientjes CA, et al: Erratum to: Multicentre randomized controlled trial comparing ferric (III)carboxymaltose infusion with oral iron supplementation in the treatment of preoperative anaemia in colorectal cancer patients. BMC Surg. 15:1102015. View Article : Google Scholar : PubMed/NCBI

34 

Laï-Tiong F, Brami C, Dubroeucq O, Scotté F, Curé H and Jovenin N: Management of anemia and iron deficiency in a cancer center in France. Support Care Cancer. 24:1091–1096. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Braga M, Gianotti L, Vignali A, Gentilini O, Servida P, Bordignon C and Di Carlo V: Evaluation of recombinant human erythropoietin to facilitate autologous blood donation before surgery in anaemic patients with cancer of the gastrointestinal tract. Br J Surg. 82:1637–1640. 1995. View Article : Google Scholar : PubMed/NCBI

36 

Jackson D, White IR, Mason D and Sutton S: A general method for handling missing binary outcome data in randomized controlled trials. Addiction. 109:1986–1993. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao F, Wang Y, Liu L and Bian M: Erythropoietin for cancer-associated malignant anemia: A meta-analysis. Mol Clin Oncol 6: 925-930, 2017.
APA
Zhao, F., Wang, Y., Liu, L., & Bian, M. (2017). Erythropoietin for cancer-associated malignant anemia: A meta-analysis. Molecular and Clinical Oncology, 6, 925-930. https://doi.org/10.3892/mco.2017.1254
MLA
Zhao, F., Wang, Y., Liu, L., Bian, M."Erythropoietin for cancer-associated malignant anemia: A meta-analysis". Molecular and Clinical Oncology 6.6 (2017): 925-930.
Chicago
Zhao, F., Wang, Y., Liu, L., Bian, M."Erythropoietin for cancer-associated malignant anemia: A meta-analysis". Molecular and Clinical Oncology 6, no. 6 (2017): 925-930. https://doi.org/10.3892/mco.2017.1254
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao F, Wang Y, Liu L and Bian M: Erythropoietin for cancer-associated malignant anemia: A meta-analysis. Mol Clin Oncol 6: 925-930, 2017.
APA
Zhao, F., Wang, Y., Liu, L., & Bian, M. (2017). Erythropoietin for cancer-associated malignant anemia: A meta-analysis. Molecular and Clinical Oncology, 6, 925-930. https://doi.org/10.3892/mco.2017.1254
MLA
Zhao, F., Wang, Y., Liu, L., Bian, M."Erythropoietin for cancer-associated malignant anemia: A meta-analysis". Molecular and Clinical Oncology 6.6 (2017): 925-930.
Chicago
Zhao, F., Wang, Y., Liu, L., Bian, M."Erythropoietin for cancer-associated malignant anemia: A meta-analysis". Molecular and Clinical Oncology 6, no. 6 (2017): 925-930. https://doi.org/10.3892/mco.2017.1254
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