Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
July-2017 Volume 7 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2017 Volume 7 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Factors favouring long‑term survival following recurrence in ovarian cancer

  • Authors:
    • Hiroaki Soyama
    • Masashi Takano
    • Morikazu Miyamoto
    • Tomoyuki Yoshikawa
    • Tadashi Aoyama
    • Tomoko Goto
    • Junko Hirata
    • Ayako Suzuki
    • Hidenori Sasa
    • Kenichi Furuya
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, National Defense Medical College Hospital, Tokorozawa, Saitama 359‑8513, Japan, Department of Clinical Oncology, National Defense Medical College Hospital, Tokorozawa, Saitama 359‑8513, Japan
  • Pages: 42-46
    |
    Published online on: May 17, 2017
       https://doi.org/10.3892/mco.2017.1266
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to identify clinicopathological factors in long‑term survivors following ovarian cancer recurrence. The patients who achieved longer survival after recurrence (n=18) and those who succumbed to the disease earlier (n=47) were identified and analyzed. There were no significant differences in age, performance status, stage distribution or histology between the two groups. Additionally, no significant difference was observed in progression‑free survival after primary therapy. Multivariate analyses revealed that the predictive factors for long‑term survival were i) secondary debulking surgery (OR=13.3; 95% CI: 1.39‑226.7), ii) favourable response rate of second‑line chemotherapy (OR=46.5; 95% CI: 1.84‑313‑4), and iii) ≥3 regimens after first recurrence (OR=9.01; 95% CI: 1.28‑117.7). This study revealed that prolonged post‑progression survival was associated with post‑recurrence treatment. Therefore, appropriate selection of secondary debulking surgery and better chemotherapeutic response may lead to prolonged post‑progression survival in recurrent ovarian cancer patients.
View Figures

Figure 1

Figure 2

View References

1 

Ozols RF: Systemic therapy for ovarian cancer: Current status and new treatment. Semin Oncol. 33 2 Suppl 6:S3–S11. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Sundar S, Wu J, Hillaby K, Yap J and Lilford R: A systematic review evaluating the relationship between progression free survival and post progression survival in advanced ovarian cancer. Gynecol Oncol. 125:493–499. 2012. View Article : Google Scholar : PubMed/NCBI

3 

van der Burg ME, De Wit R, van Putten WL, Logmans A, Kruit WH, Stoter G and Verweij J: Weekly cisplatin and daily oral etoposide is highly effective in platinum pretreated ovarian cancer. Br J Cancer. 86:19–25. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Zang RY, Zhand ZY, Li ZT, Cai SM, Tang MQ, Chen J and Liu Q: Impact of secondary cytoreductive surgery on survival of patients with advanced epithelial ovarian cancer. Eur J Surg Oncol. 26:798–804. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Rustin GJ, Vergote I, Eisenhauer E, Pujade-Lauraine E, Quinn M, Thigpen T, du Bois A, Kristensen G, Jakobsen A, Sagae S, et al: Definitions for response and progression in ovarian cancer clinical trials incorporating RECIST 1.1 and CA 125 agreed by the Gynecological Cancer Intergroup (GCIG). Int J Gynecol Cancer. 21:419–423. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Shimokawa M, Ohki M and Kaku T: Correlation of progression-free and post-progression survival with overall survival in phase III trials of first-line chemotherapy for advanced epithelial ovarian cancer. Eur J Gynaecol Oncol. 36:370–375. 2015.PubMed/NCBI

8 

Vidal F, Guerby P, Luyckx M, Haddad P, Stoeckle E, Morice P, Leblanc E, Lecuru F, Daraï E, Classe JM, et al: Are early relapses in advanced-stage ovarian cancer doomed to a poor prognosis? PLoS One. 11:e01477872016. View Article : Google Scholar : PubMed/NCBI

9 

Petrillo M, Anchora L Pedone, Tortorella L, Fanfani F, Gallotta V, Pacciani M, Scambia G and Fagotti A: Secondary cytoreductive surgery in patients with isolated platinum-resistant recurrent ovarian cancer: A retrospective analysis. Gynecol Oncol. 134:257–261. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Bristow RE, Puri I and Chi DS: Cytoreductive surgery for recurrent ovarian cancer: A meta-analysis. Gynecol Oncol. 112:265–274. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Salani R, Santillan A, Zahurak ML, Giuntoli RL II, Gardner GJ, Armstrong DK and Bristow RE: Secondary cytoreductive surgery for localized, recurrent epithelial ovarian cancer: Analysis of prognostic factors and survival outcome. Cancer. 109:685–691. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Laas E, Luyckx M, De Cuypere M, Selle F, Daraï E, Querleu D, Rouzier R and Chéreau E: Secondary complete cytoreduction in recurrent ovarian cancer: Benefit of optimal patient selection using scoring system. Int J Gynecol Cancer. 24:238–246. 2014. View Article : Google Scholar : PubMed/NCBI

13 

van de Laar R, Massuger LF, van Gorp T, IntHout J, Zusterzeel PL and Kruitwagen RF: External validation of two prediction models of complete secondary cytoreductive surgery in patients with recurrent epithelial ovarian cancer. Gynecol Oncol. 137:210–215. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Harter P, du Bois A, Hahmann M, Hasenburg A, Burges A, Loibl S, Gropp M, Huober J, Fink D, Schröder W, et al: Surgery in recurrent ovarian cancer: The arbeitsgemeinchaft gynaekologische onkologie (AGO) DESKTOP OVAR trial. Ann Surg Oncol. 13:1702–1710. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Tian WJ, Chi DS, Sehouli J, Tropé CG, Jiang R, Ayhan A, Cormio G, Xing Y, Breitbach GP, Braicu EI, et al: A risk model for secondary cytoreductive surgery in recurrent ovarian cancer: An evidence-based proposal for patient selection. Ann Surg Oncol. 19:597–604. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Vergote IB, Garcia A, Micha J, Pippitt C, Bendell J, Spitz D, Reed N, Dark G, Fracasso PM, Ibrahim EN, et al: Randomized multicenter phase II trial comparing two schedules of etirinotecan pegol (NKTR-102) in women with recurrent platinum-resistant/refractory epithelial ovarian cancer. J Clin Oncol. 31:4060–4066. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Markman M, Markman J, Webster K, Zanotti K, Kulp B, Peterson G and Belinson J: Duration of response to second-line, platinum-based chemotherapy for ovarian cancer: Implications for patient management and clinical trial design. J Clin Oncol. 22:3120–3125. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Hoskins PJ and Le N: Identifying patients unlikely to benefit from further chemotherapy: A descriptive study of outcome at each relapse in ovarian cancer. Gynecol Oncol. 97:862–869. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Griffiths RW, Zee YK, Evans S, Mitchell CL, Kumaran GC, Welch RS, Jayson GC, Clamp AR and Hasan J: Outcomes after multiple lines of chemotherapy for platinum-resistant epithelial cancers of the ovary, peritoneum, and fallopian tube. Int J Gynecol Cancer. 21:58–65. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Sun C, Li N, Ding D, Weng D, Meng L, Chen G and Ma D: The role of BRCA status on the prognosis of patients with epithelial ovarian cancer: A systematic review of the literature with a meta-analysis. PLoS One. 9:e952852014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Soyama H, Takano M, Miyamoto M, Yoshikawa T, Aoyama T, Goto T, Hirata J, Suzuki A, Sasa H, Furuya K, Furuya K, et al: Factors favouring long‑term survival following recurrence in ovarian cancer. Mol Clin Oncol 7: 42-46, 2017.
APA
Soyama, H., Takano, M., Miyamoto, M., Yoshikawa, T., Aoyama, T., Goto, T. ... Furuya, K. (2017). Factors favouring long‑term survival following recurrence in ovarian cancer. Molecular and Clinical Oncology, 7, 42-46. https://doi.org/10.3892/mco.2017.1266
MLA
Soyama, H., Takano, M., Miyamoto, M., Yoshikawa, T., Aoyama, T., Goto, T., Hirata, J., Suzuki, A., Sasa, H., Furuya, K."Factors favouring long‑term survival following recurrence in ovarian cancer". Molecular and Clinical Oncology 7.1 (2017): 42-46.
Chicago
Soyama, H., Takano, M., Miyamoto, M., Yoshikawa, T., Aoyama, T., Goto, T., Hirata, J., Suzuki, A., Sasa, H., Furuya, K."Factors favouring long‑term survival following recurrence in ovarian cancer". Molecular and Clinical Oncology 7, no. 1 (2017): 42-46. https://doi.org/10.3892/mco.2017.1266
Copy and paste a formatted citation
x
Spandidos Publications style
Soyama H, Takano M, Miyamoto M, Yoshikawa T, Aoyama T, Goto T, Hirata J, Suzuki A, Sasa H, Furuya K, Furuya K, et al: Factors favouring long‑term survival following recurrence in ovarian cancer. Mol Clin Oncol 7: 42-46, 2017.
APA
Soyama, H., Takano, M., Miyamoto, M., Yoshikawa, T., Aoyama, T., Goto, T. ... Furuya, K. (2017). Factors favouring long‑term survival following recurrence in ovarian cancer. Molecular and Clinical Oncology, 7, 42-46. https://doi.org/10.3892/mco.2017.1266
MLA
Soyama, H., Takano, M., Miyamoto, M., Yoshikawa, T., Aoyama, T., Goto, T., Hirata, J., Suzuki, A., Sasa, H., Furuya, K."Factors favouring long‑term survival following recurrence in ovarian cancer". Molecular and Clinical Oncology 7.1 (2017): 42-46.
Chicago
Soyama, H., Takano, M., Miyamoto, M., Yoshikawa, T., Aoyama, T., Goto, T., Hirata, J., Suzuki, A., Sasa, H., Furuya, K."Factors favouring long‑term survival following recurrence in ovarian cancer". Molecular and Clinical Oncology 7, no. 1 (2017): 42-46. https://doi.org/10.3892/mco.2017.1266
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team