Angiomyofibroblastoma of the vulva diagnosed preoperatively: A case report

Shoji,Tadahiro; Takeshita,Ryosuke; Mukaida,Rika; Sato,Tamotsu; Taguchi,Masami; Sasou,Shunichi

doi:10.3892/mco.2017.1347

September-2017 Volume 7 Issue 3

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September-2017 Volume 7 Issue 3

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Case Report

Angiomyofibroblastoma of the vulva diagnosed preoperatively: A case report

Authors:
- Tadahiro Shoji
- Ryosuke Takeshita
- Rika Mukaida
- Tamotsu Sato
- Masami Taguchi
- Shunichi Sasou
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Hachinohe Red Cross Hospital, Hachinohe, Aomori 039‑1104, Japan, Department of Radiology, Hachinohe Red Cross Hospital, Hachinohe, Aomori 039‑1104, Japan, Department of Pathology and Laboratory Medicine, Hachinohe Red Cross Hospital, Hachinohe, Aomori 039‑1104, Japan
Pages: 407-411
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Published online on: July 25, 2017

https://doi.org/10.3892/mco.2017.1347
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Abstract

A 50‑year‑old woman (gravida 2, para 2) first noticed a small nodule in the right labium majus 2 years prior to the initial visit to the Hachinohe Red Cross Hospital (Hachinohe, Japan), which had gradually increased in size. On physical examination, a well‑circumscribed, elastic, firm, goose egg‑sized, subcutaneous mass protruding from the right labium majus was identified. On magnetic resonance imaging (MRI), the lesion was hypointense on T1‑weighted images and was well‑circumscribed, strongly enhanced and homogeneous on gadolinium‑enhanced images, measuring 7.5x4 cm. The same tumor had measured 2.6 cm on an MRI performed 6 years earlier. Based on the clinical course and imaging findings, angiomyofibroblastoma was diagnosed and surgical resection of the tumor was performed. The tumor was well‑circumscribed and highly vascular. The intraoperative blood loss was 70 ml. Histopathologically, the tumor cells were concentrated around blood vessels, were spindle‑shaped to oval with mild atypia, and were positive for vimentin, desmin, neural cell adhesion molecule (N‑CAM), CD‑34, estrogen receptor and progesterone receptor, and negative for S‑100. Based on these findings, the diagnosis of angiomyofibroblastoma was confirmed. Angiomyofibroblastoma is a benign mesenchymal tumor that occurs in the female external genitalia. Differentiation of this tumor from aggressive angiomyxoma, a fast‑growing infiltrative malignancy that occurs in the same region, may be challenging. The diagnosis of angiomyofibroblastoma is usually based on the histopathological findings of the resected specimen. The present case is of value, as the angiomyofibroblastoma was successfully diagnosed preoperatively based on the clinical course and imaging findings.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Angiomyofibroblastoma of the vulva diagnosed preoperatively: A case report

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