Ameloblastic fibro‑odontosarcoma of the mandible with active epithelial proliferation: A rare case report

Niu,Haoman; Liu,Junyu; Chen,Yu; Geng,Ning

doi:10.3892/mco.2017.1448

December-2017 Volume 7 Issue 6

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December-2017 Volume 7 Issue 6

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Case Report Open Access

Ameloblastic fibro‑odontosarcoma of the mandible with active epithelial proliferation: A rare case report

Authors:
- Haoman Niu
- Junyu Liu
- Yu Chen
- Ning Geng
View Affiliations / Copyright

Affiliations: State Key Laboratory of Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China

Copyright: © Niu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 971-975
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Published online on: October 12, 2017

https://doi.org/10.3892/mco.2017.1448
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Abstract

Ameloblastic fibro‑odontosarcoma (AFOS) is an extremely rare subtype of odontogenic sarcoma, with no more than 19 cases reported in the English literature to date. AFOS is a biphasic neoplasm, with deposits of dentin and enamel matrix. We herein present a case of AFOS with active epithelial proliferation in a 31‑year‑old female patient. The patient was referred to the West China Hospital of Stomatology (Chengdu, China) due to a 6‑month history of a swelling in the left mandible. Following clinical and radiological examination, the initial preoperative diagnosis was ameloblastoma, with local invasion and the possibility of malignant transformation. Left hemimandibular resection was subsequently performed. The postoperative histopathological diagnosis was AFOS, accompanied by active epithelial proliferation. Immunohistochemically, cytokeratin (CK)14 and CK19 were intensely positive in the epithelium, whereas the mesenchymal cells were strongly positive for vimentin. The Ki‑67 labeling index was considerably higher in the mesenchymal component (mean, 40%) compared with that in the epithelial element (mean, 5‑8%). Three months after the surgical procedure, the patient remained clinically and radiologically disease‑free.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Ameloblastic fibro‑odontosarcoma of the mandible with active epithelial proliferation: A rare case report

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