The multiple faces of Langerhans cell histiocytosis in childhood: A gentle reminder

Papadopoulou,Maria; Panagopoulou,Paraskevi; Papadopoulou,Anastasia; Hatzipantelis,Emmanuel; Efstratiou,Ioannis; Galli‑Tsinopoulou,Assimina; Papadopoulou‑Alataki,Efimia

doi:10.3892/mco.2017.1539

March-2018 Volume 8 Issue 3

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March-2018 Volume 8 Issue 3

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Article

The multiple faces of Langerhans cell histiocytosis in childhood: A gentle reminder

Authors:
- Maria Papadopoulou
- Paraskevi Panagopoulou
- Anastasia Papadopoulou
- Emmanuel Hatzipantelis
- Ioannis Efstratiou
- Assimina Galli‑Tsinopoulou
- Efimia Papadopoulou‑Alataki
View Affiliations / Copyright

Affiliations: Fourth Department of Pediatrics, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 56403 Thessaloniki, Greece, Second Department of Pediatrics, Aristotle University of Thessaloniki, AHEPA General Hospital, 56403 Thessaloniki, Greece, Pathology Department, Papageorgiou General Hospital, 56403 Thessaloniki, Greece
Pages: 489-492
|
Published online on: December 18, 2017

https://doi.org/10.3892/mco.2017.1539
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Abstract

Langerhans cell histiocytosis (LCH) is a rare hematologic disorder that results from the clonal multiplication and accumulation of immature dendritic Langerhans cells. Its reported incidence rate varies, but is considered to be 2.6‑8.9 per million children who are <15 years of age each year. It may affect any system or organ. The present study reported 4 pediatric LCH cases in order to highlight the heterogeneity of the initial presentation, and the pitfalls that may mislead clinicians and delay diagnosis. The clinical features, as well as the pathognomonic imaging, pathology findings and treatment options were presented. LCH may be rare, but it should always be included in the differential diagnosis of persistent eczema, unexplained skin lesions, diabetes insipidus and persistent bone pain, among others. While the debate on pathogenesis and treatment is ongoing, high index of suspicion among pediatricians, pediatric oncologists and other specialists (pathologists, dermatologists, orthopaedic surgeons, general practitioners or family physicians) is essential for early diagnosis, and optimal outcome.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

The multiple faces of Langerhans cell histiocytosis in childhood: A gentle reminder

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