Diagnostic usefulness of KL-6 concentration of bile in biliary tract cancer

Onoyama,Takumi; Matsumoto,Kazuya; Koda,Hiroki; Yamashita,Taro; Kurumi,Hiroki; Kawata,Soichiro; Takeda,Yohei; Harada,Kenichi; Yashima ,Kazuo; Isomoto,Hajime

doi:10.3892/mco.2018.1571

April-2018 Volume 8 Issue 4

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April-2018 Volume 8 Issue 4

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Article

Diagnostic usefulness of KL-6 concentration of bile in biliary tract cancer

Authors:
- Takumi Onoyama
- Kazuya Matsumoto
- Hiroki Koda
- Taro Yamashita
- Hiroki Kurumi
- Soichiro Kawata
- Yohei Takeda
- Kenichi Harada
- Kazuo Yashima
- Hajime Isomoto
View Affiliations / Copyright

Affiliations: Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683‑8504, Japan
Pages: 561-566
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Published online on: February 12, 2018

https://doi.org/10.3892/mco.2018.1571
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Abstract

The sensitivity of bile cytology for biliary tract cancer varies from 6‑64%, and hence remains unsatisfactory. Sialylated carbohydrate antigen KL‑6 mucin is positive in biliary tract cancer tissues and serum KL‑6 levels are significantly increased in intrahepatic ductal adenocarcinoma patients compared with healthy individuals. The aim of the present study was to evaluate the usefulness of the KL‑6 concentration of bile for the diagnosis of biliary tract cancer. Bile cytology and measurements of bile KL‑6 concentration were conducted for 43 patients (25 biliary tract cancers and 18 benign biliary disease). The concentration of KL‑6 in the bile of the biliary tract cancer group was compared with the benign biliary disease group. The diagnostic ability was assessed by using receiver operating characteristic curves (ROC). The mean KL‑6 concentration of bile for biliary tract cancer (34.6±51.6 U/ml) was increased compared with benign biliary disease (5.2±3.9 U/ml, P<0.001). The area under the ROC for diagnosis of biliary tract cancer was 0.84 for benign biliary disease. When the cut‑off level of the KL‑6 concentration of bile was 8.6 U/ml, the sensitivity, specificity, and accuracy of the KL‑6 concentration of bile alone for the diagnosis of biliary tract cancer were 72, 89, and 79%, respectively. Adding the bile KL‑6 concentration to bile cytology measurements, the sensitivity for the diagnosis of biliary tract cancer was increased significantly (100%, P=0.0184). The KL‑6 concentration of bile may strengthen the sensitivity of bile cytology for biliary tract cancer.

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1	Murphy G, Pfeiffer R, Camargo MC and Rabkin CS: Meta-analysis shows that prevalence of Epstein-Barr virus-positive gastric cancer differs based on sex and anatomic location. Gastroenterology. 137:824–833. 2009. View Article : Google Scholar : PubMed/NCBI
2	Liang Q, Yao X, Tang S, Zhang J, Yau TO, Li X, Tang CM, Kang W, Lung RW, Li JW, et al: Integrative identification of Epstein-Barr virus-associated mutations and epigenetic alterations in gastric cancer. Gastroenterology. 147:1350–1362.e4. 2014. View Article : Google Scholar : PubMed/NCBI
3	Lim H, Park YS, Lee JH, Son DH, Ahn JY, Choi KS, Kim DH, Choi KD, Song HJ, Lee GH, et al: Features of gastric carcinoma with lymphoid stroma associated with Epstein-Barr virus. Clin Gastroenterol Hepatol. 13:1738–1744.e2. 2015. View Article : Google Scholar : PubMed/NCBI
4	Watanabe H, Enjoji M and Imai T: Gastric carcinoma with lymphoid stroma. Its morphologic characteristics and prognostic correlations. Cancer. 38:232–243. 1976. View Article : Google Scholar : PubMed/NCBI
5	Namikawa T, Kitagawa H, Iwabu J, Okabayashi T, Sugimoto T, Kobayashi M and Hanazaki K: Clinicopathological properties of the superficial spreading type early gastric cancer. J Gastrointest Surg. 14:52–57. 2010. View Article : Google Scholar : PubMed/NCBI
6	Japanese Gastric Cancer Association, . Japanese classification of gastric carcinoma: III English edition. Gastric Cancer. 14:101–112. 2011. View Article : Google Scholar : PubMed/NCBI
7	Choi MG, Jeong JY, Kim KM, Bae JM, Noh JH, Sohn TS and Kim S: Clinical significance of gastritis cystica profunda and its association with Epstein-Barr virus in gastric cancer. Cancer. 118:5227–5233. 2012. View Article : Google Scholar : PubMed/NCBI
8	Huh CW, Jung DH, Kim H, Kim H, Youn YH, Park H, Kim JW, Choi SH, Noh SH and Kim JH: Clinicopathologic features of gastric carcinoma with lymphoid stroma in early gastric cancer. J Surg Oncol. 114:769–772. 2016. View Article : Google Scholar : PubMed/NCBI
9	Huang KH, Wang RF, Yang MH, Wu CW, Fang WL, Li AF, Chi CW and Kao HL: Advanced gastric cancer patients with lymphoid stroma have better survival than those without. J Surg Oncol. 107:523–528. 2013. View Article : Google Scholar : PubMed/NCBI
10	Kim TJ, Lee H, Min YW, Min BH, Lee JH, Kim KM, Kim MJ, Kim K, Rhee PL and Kim JJ: One-dimensional and 2-dimensional tumor size measurement for prediction of lymph node metastasis in differentiated early gastric cancer with minute submucosal invasion. Gastrointest Endosc. 85:730–736. 2017. View Article : Google Scholar : PubMed/NCBI
11	Shin DH, Kim GH, Lee BE, Lee JW, Ha DW, Jeon HK, Baek DH, Song GA, Ahn SJ and Park DY: Clinicopathologic features of early gastric carcinoma with lymphoid stroma and feasibility of endoscopic submucosal dissection. Surg Endosc. April 13–2017. View Article : Google Scholar : (Epub ahead of print). View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Diagnostic usefulness of KL-6 concentration of bile in biliary tract cancer

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